Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus [PDF]
, 1991 D. A. Hosford +7 more
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Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
British Journal of Pharmacology, EarlyView.Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley +1 more source
Involvement of N-rnethy1-D-aspartic acid (NMDA) receptor in the central mechanism of cough reflex
, 1990 Hideo Honda +5 more
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The Sharpey‐Schafer Prize Lecture. The mechanism of induction of NMDA receptor‐dependent long‐term potentiation in the hippocampus [PDF]
, 1992 Graham L. Collingridge
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Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases
British Journal of Pharmacology, EarlyView.Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota +4 more
wiley +1 more source
Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours
Cell Proliferation, EarlyView.During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin +6 more
wiley +1 more source
Genetic testing in cerebral palsy with clinical and neuroimaging variables
Developmental Medicine &Child Neurology, EarlyView.Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16334 Abstract Aim To optimize genetic testing in children with cerebral palsy (CP) by using clinical and magnetic resonance imaging (MRI) variables. Method In this mixed methods study, we surveyed current approaches to genetic testing by Australian clinicians involved in the ...
Esther M. Tantsis +46 more
wiley +1 more source
Cortical hemodynamics of electrographic status epilepticus in the critically ill
Epilepsia, Volume 66, Issue 3, Page 802-816, March 2025.Abstract Objectives The pathophysiological mechanisms of status epilepticus (SE) underlying potential brain injury remain largely unclear. This study aims to employ functional near‐infrared spectroscopy (fNIRS) combined with video‐electroencephalography (vEEG) to monitor brain hemodynamics continuously and non‐invasively in critically ill adult ...
Ali Kassab +6 more
wiley +1 more source