Results 251 to 260 of about 2,517,861 (360)

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2013
S. Nabavi   +5 more
semanticscholar   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

open access: yesJournal of Internal Medicine, EarlyView.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Pharmacokinetics and Safety of a Single Subcutaneous or Intramuscular Dose of Ketamine in Healthy Horses

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes.
Ana Rangel   +5 more
wiley   +1 more source

RIN1 regulates developmental and pain-related plasticity in spinal synapses via NMDA receptor subunit trafficking. [PDF]

open access: yesPLoS Biol
Bai HH   +11 more
europepmc   +1 more source

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

open access: green, 2009
Angela Brennan   +8 more
openalex   +1 more source

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

open access: yesObesity Reviews, EarlyView.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick   +3 more
wiley   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang   +3 more
wiley   +1 more source

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