Results 31 to 40 of about 22,217 (292)

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

Intersubunit Cooperativity in the NMDA Receptor [PDF]

Neuron, 2001
Opening of the NMDA receptor channel requires simultaneous binding of glutamate and glycine. Although the binding sites for each agonist are in different subunits, the presence of one agonist influences the binding of the other. We have localized regions in the S1 binding domain of both subunits required for the transmission of allosteric signals from ...
Juan Lerma, M Paz Regalado, Alvaro Villarroel   +2 more
openaire   +4 more sources

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

Brain, 2023
Abstract N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common subtype of autoimmune encephalitis characterized by a complex neuropsychiatric syndrome usually including memory impairment. Patients develop an intrathecal immune response against NMDARs with antibodies that presumably bind to the amino-terminal domain of the
Stephan Steinke, Toni Kirmann, Eleonora A Loi, Jana Nerlich, Iron Weichard, Philipp Kuhn, Torsten Bullmann, Andreas Ritzau-Jost, Filiz Sila Rizalar, Harald Prüss, Volker Haucke, Christian Geis, Michael Hust, Stefan Hallermann   +13 more
openaire   +3 more sources

Targeting B cells and plasma cells in autoimmune diseases: From established treatments to novel therapeutic approaches

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
B lineage cells have been identified as therapeutic targets in autoimmune diseases. In the current review article, we provide an overview of novel strategies to target B lineage cells in autoimmune diseases, with a focus on inflammatory rheumatic diseases.
Ana Merino‐Vico, Giulia Frazzei, Jan Piet van Hamburg, Sander W. Tas   +3 more
wiley   +1 more source

Theory for Characterization of Hippocampal Long-Term Potentiation Induced by Time-Structured Stimuli [PDF]

J. Phys. Soc. Jpn. 66 (1997) 572 - 575, 1997
We theoretically investigate long-term potentiation (LTP) in the hippocampus using a simple model of a neuron stimulated by three different time-structured input signals (regular, Markov, and chaotic). The synaptic efficacy change is described taking into account both N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
arxiv   +1 more source

Remembering Mechanosensitivity of NMDA Receptors [PDF]

Frontiers in Cellular Neuroscience, 2019
An increase in post-synaptic Ca2+ conductance through activation of the ionotropic N-methyl-D-aspartate receptor (NMDAR) and concomitant structural changes are essential for the initiation of long-term potentiation (LTP) and memory formation. Memories can be initiated by coincident events, as occurs in classical conditioning, where the NMDAR can act as
Luke R. Johnson, Luke R. Johnson, Luke R. Johnson, Luke R. Johnson, Luke R. Johnson, Andrew R. Battle, Andrew R. Battle, Andrew R. Battle, Boris Martinac, Boris Martinac   +9 more
openaire   +5 more sources

Enantioselective CE–MS analysis of ketamine metabolites in urine

ELECTROPHORESIS, Volume 44, Issue 1-2, Page 125-134, January 2023., 2023
Abstract The chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression. The metabolite hydroxynorketamine (HNK) plays an important role in the antidepressant mechanism of action.
Friederike A. Sandbaumhüter, Jordan T. Aerts, Regula Theurillat, Per E. Andrén, Wolfgang Thormann, Erik T. Jansson   +5 more
wiley   +1 more source

Allosteric Inhibitors of NMDA Receptor Functions

Pharmaceuticals, 2010
NMDA receptors are glutamate-activated ion-channels involved in many essential brain functions including learning, memory, cognition, and behavior. Given this broad range of function it is not surprising that the initial attempts to correct NMDA receptor-
William F. Borschel, Gabriela K. Popescu, Swetha Murthy   +2 more
doaj   +1 more source

Clinical characteristics of anti-N-methyl-d-aspartate receptor encephalitis in patients with a long-term history of mental disorders

European Journal of Medical Research, 2022
Background Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is an autoimmune disorder characterized by complex neuropsychiatric syndromes during disease onset.
Hai-Yang Wang, Xiao-Yu Yang, Jinming Han, Huakun Liu, Zhong-Rui Yan, Zhanhua Liang   +5 more
doaj   +1 more source

Synaptic NR2A- but not NR2B-containing NMDA receptors increase with blockade of ionotropic glutamate receptors

Frontiers in Molecular Neuroscience, 2009
NMDA receptors are key molecules involved in physiological and pathophysiological brain processes such as plasticity and excitotoxicity. Neuronal activity regulates NMDA receptor levels in the cell membrane.
Jakob Von Engelhardt, Beril Doganci, Peter H Seeburg, Hannah Monyer   +3 more
doaj   +1 more source