Results 11 to 20 of about 406,460 (331)

Ultrahigh‐Resolution NMR Spectroscopy [PDF]

open access: yesAngewandte Chemie International Edition, 2014
All psyched up: A flexible and general pure shift experiment (PSYCHE) has been developed that offers superior sensitivity, spectral purity, and tolerance of strong coupling over existing methods for broadband homonuclear decoupling. The partial spectra of estradiol in [D6]DMSO obtained by normal 1H NMR spectroscopy and PSYCHE are shown for comparison.
Foroozandeh, Mohammadali   +5 more
openaire   +4 more sources

Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis

open access: yesScientific Reports, 2020
The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear.
Sergey A. Goncharuk   +4 more
doaj   +1 more source

Enantiotropy of Simvastatin as a Result of Weakened Interactions in the Crystal Lattice: Entropy-Driven Double Transitions and the Transient Modulated Phase as Seen by Solid-State NMR Spectroscopy

open access: yesMolecules, 2022
In crystalline molecular solids, in the absence of strong intermolecular interactions, entropy-driven processes play a key role in the formation of dynamically modulated transient phases.
Jiri Brus   +3 more
doaj   +1 more source

Ruthenium Olefin Metathesis Catalysts Bearing Carbohydrate-Based N-Heterocyclic Carbenes [PDF]

open access: yes, 2010
Ru-based olefin metathesis catalysts containing carbohydrate-derived NHCs from glucose and galactose were synthesized and characterized by NMR spectroscopy. 2D-NMR spectroscopy revealed the presence of Ru−C (benzylidene) rotamers at room temperature, and
Grubbs, Robert H., Keitz, Benjamin K.
core   +2 more sources

Protein NMR spectroscopy [PDF]

open access: yesCurrent Biology, 1998
Protein NMR spectroscopy does have its limitations. It has so far been used mainly for small proteins with molecular weight of less than 30 kDa, although a handful of publications have now reported the NMR study of proteins up to 40–50 kDa. Larger proteins typically have faster relaxation rates, which results in fatter NMR peaks that tend to merge with
openaire   +2 more sources

Energetics of Excitatory and Inhibitory Neurotransmission in Aluminum Chloride Model of Alzheimer’s Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor

open access: yesFrontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized by progressive loss of cognitive functions and memory. Excessive intake of aluminum chloride in drinking water is associated with amyloid plaques and neurofibrillary ...
Kamal Saba   +6 more
doaj   +1 more source

A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

open access: yesNature Communications, 2022
Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.
Ahmed Rohaim   +8 more
doaj   +1 more source

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting

open access: yesMembranes, 2015
Phosphatidylinositol 3-kinase-related kinases (PIKKs) play vital roles in the regulation of cell growth, proliferation, survival, and consequently metabolism, as well as in the cellular response to stresses such as ionizing radiation or redox changes. In
Maristella De Cicco   +2 more
doaj   +1 more source

Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR

open access: yesNature Communications, 2018
The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA ...
Cecilia Pinto   +5 more
doaj   +1 more source

Insight into Solvent Coordination of an Iron Porphyrin Hydroxylamine Complex from Spectroscopy and DFT Calculations [PDF]

open access: yes, 2018
The reduction of Fe(OEP)(NO) in the presence of substituted phenols leads to a three‐electron reduction to form Fe(OEP)(NH2OH), which has been characterized by visible spectroscopy and electron stoichiometry.
Rahman, Md. Hafizur, Ryan, Michael D.
core   +2 more sources

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