Results 41 to 50 of about 343,916 (274)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

NMR-based metabolomics analysis of organic and conventionally produced formula milk: preliminary results

open access: yesJournal of Pediatric and Neonatal Individualized Medicine, 2019
Proceedings of the 15th International Workshop on Neonatology and the 40th Congress UMEMPS (Union of Middle-Eastern and Mediterranean Pediatric Societies) • Cagliari (Italy) • October 24th-26th, 2019 • Children of the Middle-Eastern and Mediter­ranean ...
Sara Corbu   +5 more
doaj   +1 more source

Investigation of Physico Chemical, Mechanical and Thermal Properties of the Albizia Lebbeck Bark Fibers

open access: yesJournal of Natural Fibers, 2021
The production of materials using synthetic fibers is a strong contributor to carbon emissions and waste. Because of growing environmental consciousness, natural fibers act as a substitute for synthetic fibers due to their renewable, eco-friendly and bio-
P. Manimaran   +2 more
doaj   +1 more source

Analysis of Cross-species Anatomical Connection Differences Between Human and Macaque Broca Region

open access: yesTaiyuan Ligong Daxue xuebao, 2021
On the basis of the idea of comparative neuroscience, the brain atlas registration method was used to extract Broca target brain regions and 10 regions of interest from each subject brain of humans and macaques, and a connectivity fingerprint was ...
Kaixin REN   +4 more
doaj   +1 more source

NMR analogues of the quantum Zeno effect [PDF]

open access: yes, 2005
We describe Nuclear Magnetic Resonance (NMR) demonstrations of the quantum Zeno effect, and discuss briefly how these are related to similar phenomena in more conventional NMR experiments.
arxiv   +1 more source

Theoretical study of NMR relaxation due to rattling phonons [PDF]

open access: yesJ. Phys. Chem. Solids 69, 3160 (2008), 2007
We calculate the NMR relaxation rate due to quadrupolar coupling of the nucleus to a local, strongly anharmonic phonon mode. As a model potential for a rattling motion we consider a square-well potential. We calculate the free phonon Green's function analytically and derive the low and high temperature limits of the NMR relaxation rate.
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

A real case study on the physicochemical changes in crude palm oil (Elaeis guineensis) during the deep-frying of akara, traditional cowpea-paste balls, in Brazil

open access: yesGrasas y Aceites, 2019
The objective of this study was to evaluate the physicochemical changes in crude palm oil during a real case of deep-frying of akara, cowpea-paste balls, fried and sold in the streets of Brazil.
S. Feitosa   +6 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Determinação da Estrutura de Diferentes Álcoois Terpênicos: Um Estudo Teórico e Experimental

open access: yesOrbital: The Electronic Journal of Chemistry, 2013
Terpene compounds is a major class of natural products found in nature, although having a relatively simple structure, their 1H-NMR spectra and 13C are complex and have many overlapping signals.
Naiara Letícia Marana   +2 more
doaj   +1 more source

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