Results 21 to 30 of about 560,508 (333)

Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy

Nature Communications, 2019
Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and ...
Reinier Damman, Stefan Schütz, Yanzhang Luo, Markus Weingarth, Remco Sprangers, Marc Baldus   +5 more
doaj   +1 more source

Characterization of the cell wall of a mushroom forming fungus at atomic resolution using solid-state NMR spectroscopy

The Cell Surface, 2020
Cell walls are essential in the interaction of fungi with the (a)biotic environment and are also key to hyphal morphogenesis and mechanical strength. Here, we used solid-state NMR (ssNMR) spectroscopy combined with HPLC and GC–MS to study the structural ...
Helena Leona Ehren, Freek V.W. Appels, Klaartje Houben, Marie A.M. Renault, Han A.B. Wösten, Marc Baldus   +5 more
doaj   +1 more source

5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6- (3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one [PDF]

, 2018
Natural and semi-synthetic compounds are being studied as novel phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction, pulmonary hypertension, and lower urinary symptoms.
Ongaro, Alberto, Ribaudo, Giovanni, Zagotto, Giuseppe   +2 more
core   +1 more source

Probing Nuclear Dipole Moments and Magnetic Shielding Constants through 3-Helium NMR Spectroscopy

Physchem, 2022
Multinuclear NMR studies of the gaseous mixtures that involve volatile compounds and 3He atoms are featured in this review. The precise analyses of 3He and other nuclei resonance frequencies show linear dependencies on gas density.
Włodzimierz Makulski
doaj   +1 more source

Shifts in the selectivity filter dynamics cause modal gating in K+ channels

Nature Communications, 2019
Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels
Shehrazade Jekhmane, João Medeiros-Silva, Jing Li, Felix Kümmerer, Christoph Müller-Hermes, Marc Baldus, Benoît Roux, Markus Weingarth   +7 more
doaj   +1 more source

Biological solid-state NMR: Integrative across different scientific disciplines

Journal of Structural Biology: X, 2022
For almost five decades, solid-state NMR (ssNMR) has been used to study complex biomolecular systems. This article gives a view on how ssNMR methods and applications have evolved during this time period in a broader structural biology context.
Marc Baldus
doaj   +1 more source

Phase Coherence in Multiple Pulse Optical Spectroscopy [PDF]

, 1983
In this paper we describe a new technique for the generation of multiple pulse phase coherent sequences in optical spectroscopy. The technique is an extension of the acousto-optic modulation and fluorescence detection methods developed for optical ...
Warren, Warren S., Zewail, Ahmed H.
core   +1 more source

Mode of action of teixobactins in cellular membranes

Nature Communications, 2020
The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind ...
Rhythm Shukla, João Medeiros-Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das, Alessandra Lucini Paioni, Shehrazade Jekhmane, Joseph Lorent, Alexandre M. J. J. Bonvin, Marc Baldus, Moreno Lelli, Edwin J. A. Veldhuizen, Eefjan Breukink, Ishwar Singh, Markus Weingarth   +14 more
doaj   +1 more source

Binding of micro-nutrients to the cell wall of the fungus Schizophyllum commune

The Cell Surface, 2023
The cell wall fulfils several functions in the biology of fungi. For instance, it provides mechanical strength, interacts with the (a)biotic environment, and acts as a molecular sieve.
Fleur E.L. Kleijburg, Adil A. Safeer, Marc Baldus, Han A.B. Wösten   +3 more
doaj   +1 more source

NMR investigations of the interaction between the azo-dye sunset yellow and Fluorophenol [PDF]

, 2013
The interaction of small molecules with larger noncovalent assemblies is important across a wide range of disciplines. Here, we apply two complementary NMR spectroscopic methods to investigate the interaction of various fluorophenol isomers with sunset ...
Aradi F., Aradi F., Azami-Movahed M., Bernstein S. L., Brevard C., Combettes L. E., Cook T. R., Dai C., Davies D. B., Dimicoli J.-L., Dolbier W. R., Edwards D. J., Gomes C. M., Gregory D. H., Groenning M., Hazafy D., Horowitz V. R., Hunter C. A., Iain J. Day, John U., Johnson C. S., Jonathan R. Katz, Jones J. W., Joshi L., Khurana R., Kroth H., Lucy J. Day, Martin R. B., Moreira M. A., Neumann B., Nilsson M., Park H.-S., Park H.-S., Pelta M. D., Potrzebowski M. J., Prabhu U. R., Prabhu U. R., Press W. H., Price W. S., Price W. S., Price W. S., Rambaran R. N., Renshaw M. P., Tait K. M., Veselkov A. N., Weller K., West A. P., Williams J. H., Wong E. H., Wong J. P.-W., Yoshida W., Zeng P.   +51 more
core   +1 more source