Results 171 to 180 of about 23,497 (215)

Non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Expert Opinion on Investigational Drugs, 1994
Various non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been reported to specifically inhibit human immunodeficiency virus type 1 (HIV-1): for example, tetrahydroimidazobenzodiazepinone (TIBO), hydroxyethoxymethylphenylthiothymine (HEPT), dipyridodiazepinone (i.e.
openaire   +1 more source

Novel Pyridinone Derivatives As Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI-Resistant HIV-1 Strains

Journal of Medicinal Chemistry, 2013
Novel 6-substituted-4-cycloalkyloxy-pyridin-2(1H)-ones were synthesized as non-nucleoside reverse transcriptase inhibitors (NNRTIs), and their biological activity was evaluated. Most of the compounds, especially 26 and 22, bearing a 3-isopropyl and 3-iodine group, respectively, exhibited highly potent activity against wild-type HIV-1 strains and those ...
Amin, Li, Yabo, Ouyang, Ziyun, Wang, Yuanyuan, Cao, Xiangyi, Liu, Li, Ran, Chao, Li, Li, Li, Liang, Zhang, Kang, Qiao, Weisi, Xu, Yang, Huang, Zhili, Zhang, Chao, Tian, Zhenming, Liu, Shibo, Jiang, Yiming, Shao, Yansheng, Du, Liying, Ma, Xiaowei, Wang, Junyi, Liu   +20 more
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Neuer NNRTI zugelassen

CME, 2019
  +4 more sources

NNRTI TBZ analoghi: progettazione razionale, sintesi e SAR

2004
Pisa
BARRECA M. L, RAO A, DE LUCA, Laura, MONFORTE, Anna Maria, ZAPPALA', Maria, MAGA G, DE CLERCQ E, CHIMIRRI, Alba, MONFORTE P.   +8 more
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A Novel NNRTI Class with Potent Anti-HIV Activity Against NNRTI-resistant Viruses

Antiviral Research, 2008
Anneke Raney, Robert Hamatake, Wen Xu, Jean-Luc Girardet, Jean-Michel Vernier, Li-Tain Yeh, Barry Quart   +6 more
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NNRTI-related or -unrelated hepatotoxicity?

Hepatology, 2002
Pascal, Lebray, Yves, Benhamou, Stanislas, Pol, Robert P, Myers, Thierry, Poynard, Vincent, Di Martino   +5 more
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Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase

European Journal of Medicinal Chemistry, 2021
Da Feng, Xiaofang Zuo, Chin-Ho Chen
exaly  

Review of NNRTIs: 'today and tomorrow'.

International journal of clinical practice. Supplement, 2000
Since 1996 indinavir in combination with zidovudine + lamivudine has been the standard regimen in the treatment of HIV infection. Although protease inhibitor (PI) containing therapies are very potent, many problems have now been identified that reduce quality of life such as a high pill burden, multiple daily dosing and dietary constraints. In addition,
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Pre-treatment HIV-drug resistance associated with virologic outcome of first-line NNRTI-antiretroviral therapy: A cohort study in Kenya

EClinicalMedicine, 2020
Ingrid A Beck, Michael H Chung, Lisa M Frenkel   +2 more
exaly  

Next generation NNRTI potent against NNRTI-resistant HIV-1

Inpharma Weekly, 2005
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