Results 11 to 20 of about 3,161,134 (287)

DETERMINING THE NO-OBSERVED-ADVERSE-EFFECT LEVEL IN CATEGORICAL DATA [PDF]

Bulletin of informatics and cybernetics, 1994
Summary: We discuss the determination of the no-observed-adverse-effect level (NOAEL) from categorical data. Recently a method which incorporated the order restriction into the multiple testing was proposed by \textit{K. G. Brown} and \textit{L. S. Erdreich} [Fund. Appl. Toxicology 13, 235-244 (1989)].
Nishiyama, Harutoshi, Yanagawa, Takashi
openaire   +4 more sources

A proposal for calculating the no-observed-adverse-effect level (NOAEL) for organic compounds responsible for liver toxicity based on their physicochemical properties [PDF]

International Journal of Occupational Medicine and Environmental Health, 2014
Objectives: Both environmental and occupational exposure limits are based on the no-observed-adverse-effect level (NOAEL), lowest-observed-adverse-effect level (LOAEL) or benchmark dose (BMD) deriving from epidemiological and experimental studies.
Marek Jakubowski, Sławomir Czerczak
doaj   +3 more sources

Interpretation of toxicological research data in establishing the no observed adverse effect level (NOAEL) for medicinal products [PDF]

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Toxicological studies of new pharmaceuticals in laboratory animals represent an obligatory stage in drug risk assessment, designed to identify toxic effects, their potential reversibility, and dependence on dose and/or systemic exposure ...
K. L. Kryshen, Ya. A. Gushchin, N. M. Faustova, S. V. Gushchina, Zh. Yu. Ustenko, A. E. Katelnikova, K. T. Sultanova, A. A. Matichin, V. A. Vavilova, Ya. G. Murazov, M. V. Miroshnikov, M. A. Kovaleva, D. V. Shubin, V. G. Makarov, M. N. Makarova   +14 more
doaj   +2 more sources

The no-observed-adverse-effect level of phthalates promotes proliferation and cell cycle progression in normal human breast cells [PDF]

Taiwanese Journal of Obstetrics & Gynecology, 2023
Objective: The data on the association between phthalates and breast cancer risk remains inconsistent. This study aimed to explore the possible mechanism of low-dose exposures of phthalates, including Butyl benzyl phthalate (BBP), di(n-butyl) phthalate ...
Fang-Ping Chen, Mei-Hua Chien, Chun-Hui Lee   +2 more
doaj   +2 more sources

no observed adverse effect level [PDF]

, 2014
Citation: 'no observed adverse effect level' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.NT06911 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +2 more sources

lowest observed adverse effect level [PDF]

, 2014
Citation: 'lowest observed adverse effect level' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.LT06909 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Louise Ryan
core   +3 more sources

DETERMINING THE NO-OBSERVED-ADVERSE-EFFECT LEVEL IN CATEGORICAL DATA [PDF]

DETERMINING THE NO-OBSERVED-ADVERSE-EFFECT LEVEL IN CATEGORICAL DATA
We discuss the determination of the no-observed-adverse-effect level (NOAEL) from a categorical data. Recently a method which incorporated the order regtriction into the multiple testing was proposed in Brown and Erdreich [2]. The test is an exact test and computation ally involved for large samples.
柳川, 堯, Yanagawa, Takashi, 西山, 治利, Nishiyama, Harutoshi   +3 more
openaire   +1 more source

No observed adverse effect level assay at 6 hours and 24 hours of 1-octen-3-ol exposure. [PDF]

, 2023
No observed adverse effect level assay at 6 hours and 24 hours of 1-octen-3-ol exposure.
Babak Ebrahimi (4393384), Fredis Mappin (17277297), Matthew DeGennaro (239817), Anthony J. Bellantuono (6759242)   +3 more
core   +1 more source

Toxicity of diclofenac sodium salt in Yucatan minipigs (Sus scrofa) following 4 weeks of daily intramuscular administration

Toxicology Reports, 2021
Diclofenac sodium salt (DSS) is a widely used nonsteroidal anti-inflammatory drug. The present study was performed under good laboratory practice (GLP) regulations to investigate the toxicity of DSS after 4 weeks of repeated intramuscular administration ...
Hyung-Sun Kim, Goo-Hwa Kang, Mi-Jin Yang, Hee-Jeong Ahn, Su-Cheol Han, Jeong Ho Hwang   +5 more
doaj   +1 more source

Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats

Toxicology Reports, 2021
Thinned immature fruit of the mango tree (Mangifera indica ‘Irwin’) are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango ...
Hayato Tajiri, Wataru Tanaka, Masakatsu Takashima, Hiroki Matsuyama, Takuya Sugita, Kenta Hidaka, Hiroyuki Sakakibara   +6 more
doaj   +1 more source