Results 21 to 30 of about 3,155,563 (287)

Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. [PDF]

J Korean Med Sci, 2012
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial dysfunction by increasing oxidative stress in the liver. Two doses of BPA, 0.05 and 1.2 mg/kg body weight/day, were administered intraperitoneally for 5
Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ.   +11 more
europepmc   +3 more sources

Interpretation of toxicological research data in establishing the no observed adverse effect level (NOAEL) for medicinal products

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Toxicological studies of new pharmaceuticals in laboratory animals represent an obligatory stage in drug risk assessment, designed to identify toxic effects, their potential reversibility, and dependence on dose and/or systemic exposure ...
K. L. Kryshen, Ya. A. Gushchin, N. M. Faustova, S. V. Gushchina, Zh. Yu. Ustenko, A. E. Katelnikova, K. T. Sultanova, A. A. Matichin, V. A. Vavilova, Ya. G. Murazov, M. V. Miroshnikov, M. A. Kovaleva, D. V. Shubin, V. G. Makarov, M. N. Makarova   +14 more
doaj   +2 more sources

The no-observed-adverse-effect level of phthalates promotes proliferation and cell cycle progression in normal human breast cells

Taiwanese Journal of Obstetrics & Gynecology, 2023
Objective: The data on the association between phthalates and breast cancer risk remains inconsistent. This study aimed to explore the possible mechanism of low-dose exposures of phthalates, including Butyl benzyl phthalate (BBP), di(n-butyl) phthalate ...
Fang-Ping Chen, Mei-Hua Chien, Chun-Hui Lee   +2 more
doaj   +2 more sources

Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis. [PDF]

J Vet Med Sci
The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown.
Ishida Y, Yonoichi S, Hara Y, Shoda A, Kimura M, Murata M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Matsuo E, Ikenaka Y, Hoshi N.   +14 more
europepmc   +4 more sources

no observed adverse effect level

, 2014
Citation: 'no observed adverse effect level' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.NT06911 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +2 more sources

lowest observed adverse effect level

, 2014
Citation: 'lowest observed adverse effect level' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.LT06909 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Louise Ryan
core   +3 more sources

DETERMINING THE NO-OBSERVED-ADVERSE-EFFECT LEVEL IN CATEGORICAL DATA

DETERMINING THE NO-OBSERVED-ADVERSE-EFFECT LEVEL IN CATEGORICAL DATA
We discuss the determination of the no-observed-adverse-effect level (NOAEL) from a categorical data. Recently a method which incorporated the order regtriction into the multiple testing was proposed in Brown and Erdreich [2]. The test is an exact test and computation ally involved for large samples.
柳川, 堯, Yanagawa, Takashi, 西山, 治利, Nishiyama, Harutoshi   +3 more
openaire   +1 more source

Toxicity of diclofenac sodium salt in Yucatan minipigs (Sus scrofa) following 4 weeks of daily intramuscular administration

Toxicology Reports, 2021
Diclofenac sodium salt (DSS) is a widely used nonsteroidal anti-inflammatory drug. The present study was performed under good laboratory practice (GLP) regulations to investigate the toxicity of DSS after 4 weeks of repeated intramuscular administration ...
Hyung-Sun Kim, Goo-Hwa Kang, Mi-Jin Yang, Hee-Jeong Ahn, Su-Cheol Han, Jeong Ho Hwang   +5 more
doaj   +1 more source

Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats

Toxicology Reports, 2021
Thinned immature fruit of the mango tree (Mangifera indica ‘Irwin’) are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango ...
Hayato Tajiri, Wataru Tanaka, Masakatsu Takashima, Hiroki Matsuyama, Takuya Sugita, Kenta Hidaka, Hiroyuki Sakakibara   +6 more
doaj   +1 more source

Repeated dose (90 days) oral toxicity study of ursolic acid in Han-Wistar rats

Toxicology Reports, 2020
Background: Ursolic acid (UA) has been used in alternative medicine for decades, and there has been a great interest in its medicinal properties. Despite this increased interest, a detailed long-term toxicity study has not been performed.
Lotte Geerlofs, Zhiyong He, Sa Xiao, Zhi-Cheng Xiao   +3 more
doaj   +1 more source