Results 161 to 170 of about 6,271 (203)

Artificial Intelligence for Natural Products Drug Discovery in Neurodegenerative Therapies: A Review. [PDF]

Biomolecules
Fontanella F, D'Alessandro T, Nardone E, De Stefano C, Vicidomini C, Roviello GN.   +5 more
europepmc   +1 more source

Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway. [PDF]

Int J Mol Sci
Zhang Y, Yang Y, Liang H, Liang Y, Xiong G, Lu F, Yang K, Zou Q, Zhang X, Du G, Xu X, Hao J.   +11 more
europepmc   +1 more source

Transdermal delivery of nobiletin using ionic liquids [PDF]

Scientific Reports, 2019
AbstractNobiletin (NOB), a flavonoid, has extremely low water solubility and low oral bioavailability; however, despite these problems, various physiological effects have been investigated in vitro. In the present study, we investigated the transdermal delivery of NOB using choline and geranic acid (CAGE), which is a biocompatible material that has ...
Makoto Inai, Toshiyuki Kan, Samir Mitragotri   +2 more
exaly   +4 more sources

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Nobiletin mitigates NAFLD via lipophagy and inflammation

Food & Function, 2022
Nobiletin was found to mitigate nonalcoholic fatty liver disease by enhancing TFEB-mediated lipophagy, alleviating NLRP3 inflammasome and modulating macrophages polarization.
Xushan Yang, Yudi Deng, Yali Tu, Dongliang Feng, Wenzhen Liao   +4 more
openaire   +2 more sources

Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives

Current Pharmaceutical Design, 2023
Abstract: Cancer has remained to be one of the major challenges in medicine and regarded as the second leading cause of death worldwide. Different types of cancer may resist anti-cancer drugs following certain mutations such as those in tumor suppressor genes, exhaustion of the immune system, and overexpression of drug resistance mediators, which ...
Reza, Moazamiyanfar, Sepideh, Rezaei, Hasan, AliAshrafzadeh, Nima, Rastegar-Pouyani, Emad, Jafarzadeh, Kave, Mouludi, Ehsan, Khodamoradi, Mohsen, Zhaleh, Shahram, Taeb, Masoud, Najafi   +9 more
openaire   +2 more sources

Identification of nobiletin metabolites in mouse urine

Molecular Nutrition & Food Research, 2006
AbstractNobiletin, a major component of citrus polymethoxyflavones, has many potential significant health benefits. While the biological activities of nobiletin have been widely reported, its in vitro and in vivo metabolic fate has been rarely studied.
Shiming, Li, Zhenyu, Wang, Shengmin, Sang, Mou-Tuan, Huang, Chi-Tang, Ho   +4 more
openaire   +2 more sources

Nobiletin a Biologically Active Phytoconstituent: Systematic Review

Journal of Biologically Active Products from Nature, 2021
Nobiletin is an abundant phytoconstituent having multiple pharmacological activities. Various citrus species like orange (Citrus sinensis), lemon (Citrus limon), grapefruit (Citrus paradisi) and ta...
Alok P Singh, Jai B Kandpal, Rajeev K Sharma, Havagiray Chitme   +3 more
openaire   +1 more source

How can nobiletin prevent obesity?

Expert Review of Endocrinology & Metabolism, 2011
. However, elucidation of the effectiveness of flavonoid-containing foods in humans is confounded by the heterogeneity in flavonoid metabo-lism, potentially resulting in sub-therapeutic doses. In addition, the content of flavonoids in foods is variable and a considerable range exists in the bioavailability of flavonoids among human ...
Erin E Mulvihill, Murray W Huff
openaire   +1 more source

Nobiletin as a Molecule for Formulation Development: An Overview of Advanced Formulation and Nanotechnology-Based Strategies of Nobiletin

AAPS PharmSciTech, 2020
Approximately 40% of compounds in clinical drug development suffer from solubility and bioavailability challenges. Evidence from literature demonstrates the growing interest to utilize flavonoids as potential compounds owing to their widespread therapeutic utility in various ailments.
Siddharth S. Kesharwani, Pooja Mallya, Vadikari Arun Kumar, Vikas Jain, Swagat Sharma, Surajit Dey   +5 more
openaire   +2 more sources

Potential of nobiletin against Alzheimer’s disease through inhibiting neuroinflammation

Metabolic Brain Disease, 2022
This study aimed to explore the mechanism of Nobiletin attenuating Alzheimer's disease (AD) by inhibiting neuroinflammation.The expression of inflammatory cytokines and HMGB-1 in serum of AD patients were examined. Microglia (MGs) were treated with different doses of Nobiletin before LPS and Nigericin induction.
Wen, Chai, Ji, Zhang, Zhengbing, Xiang, Honglian, Zhang, Zhujun, Mei, Hongbing, Nie, Renxu, Xu, Ping, Zhang   +7 more
openaire   +2 more sources