Results 171 to 180 of about 6,271 (203)

Nobiletin: a citrus flavonoid displaying potent physiological activity

Acta Crystallographica Section C Structural Chemistry, 2016
Nobiletin [systematic name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one; C21H22O8] is a flavonoid found in citrus peels, and has been reported to show a wide range of physiological properties, including anti-inflammatory, anticancer and antidementia activities. We have solved the crystal structure of nobiletin, which revealed that the
Shuji, Noguchi, Haruka, Atsumi, Yasunori, Iwao, Toshiyuki, Kan, Shigeru, Itai   +4 more
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Protective effects of nobiletin on cisplatin induced neurotoxicity in rats

International Journal of Neuroscience, 2021
This study was designed to investigate the possible antioxidant, antiapoptotic and neuroprotective effects of nobiletin on cisplatin-induced neurotoxicity rat model by evaluating neurotrophins, antioxidants and histopathology.Forty male Wistar Albino rats were divided into four groups: control, cisplatin (CIS), cisplatin + nobiletin (CIS + NOB) and ...
Filiz, Kazak, Pınar Peker, Akalın, Gül Fatma, Yarım, Nuri, Başpınar, Özgür, Özdemir, Mehmet Burak, Ateş, Muhammed Enes, Altuğ, Mehmet Zeki Yılmaz, Deveci   +7 more
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Characteristics of nobiletin-induced effects on jejunal contractility

Fitoterapia, 2014
Nobiletin, a citrus polymethoxylated flavone, exhibits multiple biological properties including anti-inflammatory, anti-carcinogenic, and anti-insulin resistance effects. The present study found that nobiletin exerted significant stimulatory effects on the contractility of isolated rat jejunal segments in all 6 different low contractile states, and ...
Yong-Jian Xiong, Da-Peng Chen, Bo-Chao Lv, Fang-Fei Liu, Li Wang, Yuan Lin   +5 more
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Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats

Journal of Biochemical and Molecular Toxicology, 2019
AbstractThe study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of ...
Mehmet Güvenç, Mustafa Cellat, İshak Gökçek, Hüseyin Özkan, Gözde Arkalı, Akın Yakan, Şule Yurdagül Özsoy, Mesut Aksakal   +7 more
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Mechanism of Neurotrophic Action of Nobiletin in PC12D Cells

Biochemistry, 2005
Nobiletin is a nonpeptide compound with a low molecular weight from a citrus fruit and has the activity to rescue bulbectomy-induced memory impairment. Here we describe that nobiletin itself induces neurite outgrowth in PC12D cells, a rat pheochromocytoma cell line, like NGF, and the molecular mechanism of its neurotrophic action.
Hiroyuki, Nagase, Tohru, Yamakuni, Kentaro, Matsuzaki, Yuji, Maruyama, Jiro, Kasahara, Yoshimi, Hinohara, Shunzo, Kondo, Yoshihiro, Mimaki, Yutaka, Sashida, A William, Tank, Kohji, Fukunaga, Yasushi, Ohizumi   +11 more
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Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes

Biochemical and Biophysical Research Communications, 2007
Nobiletin is a polymethoxylated flavone found in certain citrus fruits. Here we demonstrate that nobiletin enhance differentiation of 3T3-L1 preadipocytes. Nobiletin dose-dependently increased accumulation of lipid droplets in adipocytes. Quantitative RT-PCR analyses indicated that nobiletin increased the expression of genes critical for acquisition of
Takeshi, Saito, Daigo, Abe, Keizo, Sekiya   +2 more
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Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats

Biotechnic & Histochemistry
We investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL (administered 20 mg/kg MTX and 10 mg/kg NBL per day); and NBL (administered 10 mg/kg/day ...
Filiz Kazak, Ahmet Uyar, Pinar Coskun, Turan Yaman   +3 more
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Ca2+-induced whey protein emulgels for the encapsulation of crystalline nobiletin: Effect of nobiletin crystals on the viscoelasticity

Food Hydrocolloids, 2019
Abstract Due to the high crystallization, nobiletin was encapsulated by Ca2+-induced whey protein concentrate (WPC)-stabilized emulgels. Hydroxypropyl methylcellulose (HPMC) was used to regulate the interfacial properties of emulsions and viscoelasticity of emulgels.
Yan Hu, Qiao Shu, Fei Liu, Lingling Lei, Bin Li, Yanping Cao, Yan Li   +6 more
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Nobiletin

2021
Hari Prasad Devkota, Anjana Adhikari-Devkota, Amina Ibrahim Dirar, Tarun Belwal   +3 more
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A Flavonoid has Neuroprotective Effect: Nobiletin

2017
The use offlavonoids promises new approach for the treatment of neurodegenerativediseases. Nobiletine is a polymethoxy flavonoid found in the citrus peel. Theneuroprotective effect of nobiletin has been demonstrated in vivo and in vitro.Nobiletine affects the signaling cascades associated with learning and memory,alleviates neurodegeneration by ...
YARIM, Gül Fatma, ÇENESİZ, Metin, YARIM, Murat, KAZAK, Filiz   +3 more
openaire   +1 more source