Results 11 to 20 of about 88,386 (325)
Frontiers in Systems Neuroscience, 2023 The assessment and management of pain and nociception is very challenging in patients unable to communicate functionally such as patients with disorders of consciousness (DoC) or in locked-in syndrome (LIS).
Estelle A. C. Bonin +17 more
doaj +2 more sources
Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]
eNeuro, 2017 The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R +7 more
core +3 more sources
TRPV1 activity and substance P release are required for corneal cold nociception [PDF]
Nature Communications, 2019 As a protective mechanism, the cornea is sensitive to noxious stimuli. Here, we show that in mice, a high proportion of corneal TRPM8+ cold-sensing fibers express the heat-sensitive TRPV1 channel.
Guo, Changxiong +6 more
core +3 more sources
Anaesthesia, 2023 Acute postoperative pain remains a critical treatment priority and has prompted a search for technologies and techniques to assist with intra‐operative analgesic monitoring and management.
H. Bornemann-Cimenti +4 more
semanticscholar +1 more source
Journal of Clinical Medicine, 2022 We present a narrative review focusing on the new role of nociception monitor in intraoperative anesthetic management. Higher invasiveness of surgery elicits a higher degree of surgical stress responses including neuroendocrine-metabolic and inflammatory-
Munetaka Hirose +7 more
semanticscholar +1 more source
Cortical spreading depression and meningeal nociception
Neurobiology of Pain, 2022 Highlights • CSD evoked persistent activation and mechanical sensitization of dural nociceptors is likely to drive the headache phase in migraine with aura.• The development of neurogenic-mediated dural vasodilatation and increased plasma protein ...
Simone Carneiro-Nascimento, D. Levy
semanticscholar +1 more source
Myristic acid reduces skin inflammation and nociception.
Journal of food biochemistry, 2021 This study evaluated the inhibitory effect of myristic acid (MA) on models of inflammation and nociception. The in vitro anti-inflammatory activities of MA were assessed on LPS-stimulated macrophages, membrane stabilization assay, and inhibition of ...
Á. Alonso-Castro +4 more
semanticscholar +1 more source
Optogenetics and photopharmacology in pain research and therapeutics
STEMedicine, 2020 Pain afflicts billions of people worldwide, who suffer especially from long-term chronic pain. This gruelling condition affects the nervous system at all levels: from the brain to the spinal cord, the Dorsal Root Ganglia (DRG) and the peripheral fibres ...
Federico Iseppon, Manuel Arcangeletti
doaj +1 more source
International Journal of Molecular Sciences, 2020 The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain.
R. Giniatullin
semanticscholar +1 more source
Effects of Δ⁹-tetrahydrocannabinol (THC) vapor inhalation in Sprague-Dawley and Wistar rats. [PDF]
, 2021 An inhalation system based on e-cigarette technology produces hypothermic and antinociceptive effects of Δ⁹-tetrahydrocannabinol (THC) in rats. Indirect comparison of some prior investigations suggested differential impact of inhaled THC between Wistar ...
Cole, Maury +4 more
core +1 more source