Results 11 to 20 of about 44,443 (273)
TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons
Scientific Reports, 2021 Increased activity and excitability (sensitisation) of a series of molecules including the transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) in pain-sensing (nociceptive) primary sensory neurons are pivotal for developing ...
Tianci Li +6 more
doaj +1 more source
Guiding opioid-free intravenous antinociception with the Analgesia Nociception Index: a case report [PDF]
Revista Brasileira de Anestesiologia, 2021 Background: Opioid-free anesthesia decreases the incidence of opioid adverse events, but its optimal antinociceptive depth has not been clearly defined.
Sean Coeckelenbergh, Jean-Pierre Estebe
doaj +3 more sources
Circulation, 2006 Mechanisms underlying cardiac pain are of major importance in cardiovascular medicine. In this review we address a fundamental clinical and experimental aspect. In particular neural circuitry involved justify a stepwise involvement of central structures responsible of reflex adjustments initiated by peripheral ischemia that can be associated with pain ...
P. G. Camici, M. Pagani
openaire +2 more sources
Calcium imaging for analgesic drug discovery
Neurobiology of Pain, 2022 Somatosensation and pain are complex phenomena involving a rangeofspecialised cell types forming different circuits within the peripheral and central nervous systems.
Federico Iseppon +2 more
doaj +1 more source
eLife, 2023 Nociception is a neural process that animals have developed to avoid potentially tissue-damaging stimuli. While nociception is triggered in the peripheral nervous system, its modulation by the central nervous system is a critical process in mammals ...
Izumi Oikawa +7 more
doaj +1 more source
Descending control of nociception in insects? [PDF]
, 2022 Modulation of nociception allows animals to optimize chances of survival by adapting their behaviour in different contexts. In mammals, this is executed by neurons from the brain and is referred to as the descending control of nociception.
Sarlak, Sajedeh +8 more
core +1 more source
Optogenetics and photopharmacology in pain research and therapeutics
STEMedicine, 2020 Pain afflicts billions of people worldwide, who suffer especially from long-term chronic pain. This gruelling condition affects the nervous system at all levels: from the brain to the spinal cord, the Dorsal Root Ganglia (DRG) and the peripheral fibres ...
Federico Iseppon, Manuel Arcangeletti
doaj +1 more source
Frontiers in Systems Neuroscience, 2023 The assessment and management of pain and nociception is very challenging in patients unable to communicate functionally such as patients with disorders of consciousness (DoC) or in locked-in syndrome (LIS).
Estelle A. C. Bonin +17 more
doaj +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor healthârelated quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Wellcome Open Research, 2018 Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression
M.A. Bangash +17 more
doaj +1 more source