Results 31 to 40 of about 14,156 (228)
PLoS Neglected Tropical Diseases, 2023 Scorpion sting envenomations (SSE) are feared by the intense pain that they produce in victims. Pain from SSE is triggered mainly by the presence of neurotoxins in the scorpion venom that modulates voltage-gated ion channels.
Felipe Cerni +8 more
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ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
Nature Communications, 2021 The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ...
Man-Xiu Xie +10 more
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The validity and applications of the analgesia nociception index: a narrative review
Frontiers in Surgery, 2023 Pain refers to the subjective, unpleasant experience that is related to illness or injury. In contrast to pain, nociception refers to the physiological neural processing of noxious stimuli, such as intra-operative surgical stimuli.
Bill Hum +5 more
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Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes
Cell ReportsSummary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain ...
M. Ali Bangash +12 more
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The Neurobiology of Nociceptive and Anti-nociceptive Systems
Pain Physician, 2005 Pain is both a sensory event of the peripheral and central nervous systems and an experience that arises from, and reciprocally can affect processes of higher consciousness. Alterations in peripheral and central neuraxes can lead to sensitization, structural modification and long-term potentiation that can overcome modulatory influence(s) and change ...
openaire +2 more sources
Do decapod crustaceans have nociceptors for extreme pH? [PDF]
PLoS ONE, 2010 Nociception is the physiological detection of noxious stimuli. Because of its obvious importance, nociception is expected to be widespread across animal taxa and to trigger robust behaviours reliably. Nociception in invertebrates, such as crustaceans, is
Sakshi Puri, Zen Faulkes
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PAIN Reports. Introduction:. The nuclear mitogen- and stress-activated kinases (MSKs) play a critical role in the development and persistence of pain after tissue injury. Objectives:. Here, we ascertained the MSK isoform, the cells and mechanisms, which mediate MSKs'
Jahanzaib Irfan +11 more
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Bulletin of Pharmaceutical Sciences. Assiut UniversityDiabetic neuropathy (DN) is one of the complications of diabetes mellitus. In the present study, melatonin’s antinociceptive effect in DN was evaluated by studying its action on the expression of the transient receptor potential vanilloid 1 channel gene (
Ehab El-Desoky +9 more
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Arthritis Care &Research, EarlyView.Objective To explore whether higher body fat and lower lean mass are associated with greater pain and worse patient‐reported physical function in individuals with hip osteoarthritis (OA). A secondary aim was to examine whether pain and patient‐reported physical function differ according to four body composition profiles: high body fat, low lean mass ...
Alexandra Ryan +10 more
wiley +1 more source
PLoS Neglected Tropical Diseases, 2013 BackgroundThe frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents.
Camila Gewehr +9 more
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