Results 31 to 40 of about 44,443 (273)

The role of cGMP and PKG-I in spinal nociceptive processing

, 2005
First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia.
Geisslinger, Gerd, Schmidtko, Achim, Gerd Geisslinger, Ruth, Peter, Niederberger, Ellen, Achim Schmidtko, Irmgard Tegeder, Franz Hofmann, Hofmann, Franz, Peter Ruth, Ellen Niederberger, Tegeder, Irmgard   +11 more
core   +1 more source

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

Cell Reports
Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain ...
M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao   +12 more
doaj   +1 more source

The Neurobiology of Nociceptive and Anti-nociceptive Systems

Pain Physician, 2005
Pain is both a sensory event of the peripheral and central nervous systems and an experience that arises from, and reciprocally can affect processes of higher consciousness. Alterations in peripheral and central neuraxes can lead to sensitization, structural modification and long-term potentiation that can overcome modulatory influence(s) and change ...
openaire   +2 more sources

P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine?

, 2002
The discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine.
Goadsby, PJ, Yolande E. Knight, Knight, Yolande E., Knight, YE, Goadsby, Peter J., Bartsch, Thorsten, Peter J. Goadsby, Kaube, Holger, Holger Kaube, Kaube, H, Thorsten Bartsch, Bartsch, T   +11 more
core   +1 more source

Do decapod crustaceans have nociceptors for extreme pH? [PDF]

PLoS ONE, 2010
Nociception is the physiological detection of noxious stimuli. Because of its obvious importance, nociception is expected to be widespread across animal taxa and to trigger robust behaviours reliably. Nociception in invertebrates, such as crustaceans, is
Sakshi Puri, Zen Faulkes
doaj   +1 more source

Nociception monitors vs. standard practice for titration of opioid administration in general anesthesia: A meta-analysis of randomized controlled trials

Frontiers in Medicine, 2022
BackgroundNociception monitors are being increasingly used during surgery, but their effectiveness in guiding intraoperative opioid administration is still uncertain.
Dandan Ma, Dandan Ma, Jiahui Ma, Huayong Chen, Dongliang Mu, Hao Kong, Lingzhi Yu   +6 more
doaj   +1 more source

Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain

PAIN Reports
. Introduction:. The nuclear mitogen- and stress-activated kinases (MSKs) play a critical role in the development and persistence of pain after tissue injury. Objectives:. Here, we ascertained the MSK isoform, the cells and mechanisms, which mediate MSKs'
Jahanzaib Irfan, Rizki M. Febrianto, Paolo La Montanara, Michelle Y Meng, Thomas H. Hutson, David Zimmermann, Krisztina Deak-Pocsai, Deemah Aldossary, Jianglin Wang, Simone Di Giovanni, Michaela Kress, Istvan Nagy   +11 more
doaj   +1 more source

Linkage between increased nociception and olfaction via a SCN9A haplotype

, 2013
Background and Aims: Mutations reducing the function of Nav1.7 sodium channels entail diminished pain perception and olfactory acuity, suggesting a link between nociception and olfaction at ion channel level.
Hummel, Thomas, Bruno G Oertel, Lötsch, Jörn, Thomas Hummel, Jörn Lötsch, Doehring, Alexandra, Dirk Heimann, Heimann, Dirk, Alexandra Doehring, Oertel, Bruno Georg   +9 more
core   +1 more source

Effect of melatonin on the expression of Trpv1 channel in dorsal root ganglia in diabetic neuropathy. An in-vitro study.

Bulletin of Pharmaceutical Sciences. Assiut University
Diabetic neuropathy (DN) is one of the complications of diabetes mellitus. In the present study, melatonin’s antinociceptive effect in DN was evaluated by studying its action on the expression of the transient receptor potential vanilloid 1 channel gene (
Ehab El-Desoky, James Cox, Jun Zhou, Safaa Salim, Jing Zhao, Ahmed Mahmoud, Samuel Gossage, John Wood, Siham Nuur, Asmaa Hasan   +9 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source