Results 51 to 60 of about 88,386 (325)

Brain oscillations differentially encode noxious stimulus intensity and pain intensity [PDF]

, 2017
Noxious stimuli induce physiological processes which commonly translate into pain. However, under certain conditions, pain intensity can substantially dissociate from stimulus intensity, e.g. during longer-lasting pain in chronic pain syndromes.
Gross, Joachim, May, Elisabeth S., Nickel, Moritz M., Ploner, Markus, Postorino, Martina, Schmidt, Paul, Ta Dinh, Son, Tiemann, Laura   +7 more
core   +1 more source

Nociception monitors vs. standard practice for titration of opioid administration in general anesthesia: A meta-analysis of randomized controlled trials

Frontiers in Medicine, 2022
BackgroundNociception monitors are being increasingly used during surgery, but their effectiveness in guiding intraoperative opioid administration is still uncertain.
Dandan Ma, Dandan Ma, Jiahui Ma, Huayong Chen, Dongliang Mu, Hao Kong, Lingzhi Yu   +6 more
doaj   +1 more source

Effect of high level of bladder filling on spinal nociception and motoneuronal excitability [PDF]

, 2015
To verify whether high level of bladder distension may counteract the inhibitory effect of descending pathways on sacral spinal cord neurons and to investigate which spinal circuitries are possibly involved in such a viscero-somatic interaction ...
Carbone, Antonio, Conte, Carmela, Coppola, Gianluca, Cortese, Francesca, Fragiotta, Gaia, Mastroianni, Santo, Palleschi, Giovanni, Pastore, ANTONIO LUIGI, Perrotta, Armando, Pierelli, Francesco, Serrao, Mariano   +10 more
core   +1 more source

Defining the Functional Role of NaV1.7 in Human Nociception

Neuron, 2019
Summary Loss-of-function mutations in NaV1.7 cause congenital insensitivity to pain (CIP); this voltage-gated sodium channel is therefore a key target for analgesic drug development.
Lucy A McDermott, Greg A Weir, Andreas C Themistocleous, A. Segerdahl, Iulia Blesneac, G. Baskozos, A. Clark, V. Millar, Liam J. Peck, D. Ebner, I. Tracey, J. Serra, D. Bennett   +12 more
semanticscholar   +1 more source

Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain

PAIN Reports
. Introduction:. The nuclear mitogen- and stress-activated kinases (MSKs) play a critical role in the development and persistence of pain after tissue injury. Objectives:. Here, we ascertained the MSK isoform, the cells and mechanisms, which mediate MSKs'
Jahanzaib Irfan, Rizki M. Febrianto, Paolo La Montanara, Michelle Y Meng, Thomas H. Hutson, David Zimmermann, Krisztina Deak-Pocsai, Deemah Aldossary, Jianglin Wang, Simone Di Giovanni, Michaela Kress, Istvan Nagy   +11 more
doaj   +1 more source

Visceral nociception

Current Review of Pain, 2000
Visceral pain is of great concern to the medical community because it remains particularly resistant to current clinical treatments. A serendipitous and initially unexplainable clinical finding that a punctate midline dorsal column lesion is effective in eliminating visceral pain, however, has initiated a resurgence of interest in the study of the ...
openaire   +3 more sources

Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer.

PLoS Neglected Tropical Diseases, 2013
BackgroundThe frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents.
Camila Gewehr, Sara Marchesan Oliveira, Mateus Fortes Rossato, Gabriela Trevisan, Gerusa Duarte Dalmolin, Flávia Karine Rigo, Célio José de Castro Júnior, Marta Nascimento Cordeiro, Juliano Ferreira, Marcus V Gomez   +9 more
doaj   +1 more source

Pain rewarded: hyperalgesic and allodynic effect of operant conditioning in healthy humans : protocol for a systematic review and meta-analysis [PDF]

, 2018
Background: "pain rewarded" is a hypothesis wherein acute pain sufferers are exposed to reinforcers and punishers from their environment that shape their behaviour, i.e. pain responses.
Adamczyk, Wacław Marceli, Buglewicz, Ewa, Bąbel, Przemysław, Luedtke, Kerstin   +3 more
core   +1 more source

Temperature‐Modulated Threshold Response in a Volatile Memristor: Toward a Biomimetic Polymodal Nociceptive System

Advanced Functional Materials, EarlyView.
This study demonstrates an artificial polymodal nociceptor whose firing threshold is actively modulated by temperature. A volatile TiN/TiOx/ZnO/TiOx/ITO memristor shows interfacial ion–driven resistive switching and membrane‐potential‐like dynamics, enabling temperature‐dependent nociceptive behavior.
Chanmin Hwang, Yuseong Jang, Myoungsu Chae, Hee‐Dong Kim   +3 more
wiley   +1 more source

Nociceptor-Enriched Genes Required for Normal Thermal Nociception

Cell Reports, 2016
Here, we describe a targeted reverse genetic screen for thermal nociception genes in Drosophila larvae. Using laser capture microdissection and microarray analyses of nociceptive and non-nociceptive neurons, we identified 275 nociceptor-enriched genes ...
Ken Honjo, Stephanie E. Mauthner, Yu Wang, J.H. Pate Skene, W. Daniel Tracey Jr.   +4 more
doaj   +1 more source