Results 51 to 60 of about 44,443 (273)

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Transcriptional reprogramming post-peripheral nerve injury: A systematic review

Neurobiology of Disease
Neuropathic pain is characterised by periodic or continuous hyperalgesia, numbness, or allodynia, and results from insults to the somatosensory nervous system.
R. Hayward, S. Moore, D. Artun, A. Madhavan, E. Harte, J.V. Torres-Pérez, I. Nagy   +6 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Nociception and the neonatal brain [PDF]

Seminars in Fetal and Neonatal Medicine, 2019
Measuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the analgesic efficacy of pharmacological and non-pharmacological
Gursul, Deniz, Hartley, Caroline, Slater, Rebeccah   +2 more
openaire   +2 more sources

Nociception-related somatosensory evoked potentials in awake dogs recorded after intra epidermal electrical stimulation

, 2009
Eur J Pain. 2009 Feb;13(2):154-60. Epub 2008 May 16. Nociception-related somatosensory evoked potentials in awake dogs recorded after intra epidermal electrical stimulation. van Oostrom H, Stienen PJ, Doornenbal A, Hellebrekers LJ. Department of Clinical
Advances in Veterinary Medicine, Doornenbal, Arie, Arie Doornenbal, Hellebrekers, L.J., van Oostrom, H., Stienen, Peter J, Hellebrekers, Ludo J, van Oostrom, Hugo, Doornenbal, A., Peter J. Stienen, Ludo J. Hellebrekers, Stienen, P.J., Hugo van Oostrom, Dep Gezondheidszorg Paard   +13 more
core   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Visceral nociception

Current Review of Pain, 2000
Visceral pain is of great concern to the medical community because it remains particularly resistant to current clinical treatments. A serendipitous and initially unexplainable clinical finding that a punctate midline dorsal column lesion is effective in eliminating visceral pain, however, has initiated a resurgence of interest in the study of the ...
openaire   +3 more sources

Participação dos receptores TRPV1 na atividade antinociceptiva do ácido 3,4,5-trimetoxidihidrocinâmico em camundongos [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2011A procura por novas moléculas com atividade analgésica significativa, principalmente oriundas ...
Lanznaster, Débora
core  

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Assessment of Nociception in Obstetric Patients During Epidural Analgesia

Journal of Obstetric Anaesthesia and Critical Care
Introduction and Aim: Nociception monitors have been used to assess pain management in anesthetized patients. The present study was set out to evaluate whether nociception level monitor gives reliable readings during labor in awaken participants, and ...
Michael Grach, Alexandra Bazhenov, Ilana Grach, Elad Attar, Naama Schwartz, Zeev Goldik, Arieh Eden   +6 more
doaj   +1 more source