Results 71 to 80 of about 88,386 (325)

Nociception-monitor-guided opioid administration in radical retropubic prostatectomy: a randomised controlled trial.

British Journal of Anaesthesia, 2020
BACKGROUND This RCT investigated the effect of opioid titration by three different nociception monitoring devices or clinical signs during general anaesthesia.
S. Funcke, H. Pinnschmidt, Charlotte Brinkmann, Stefan Wesseler, B. Beyer, Marlene Fischer, R. Nitzschke   +6 more
semanticscholar   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Assessment of Nociception in Obstetric Patients During Epidural Analgesia

Journal of Obstetric Anaesthesia and Critical Care
Introduction and Aim: Nociception monitors have been used to assess pain management in anesthetized patients. The present study was set out to evaluate whether nociception level monitor gives reliable readings during labor in awaken participants, and ...
Michael Grach, Alexandra Bazhenov, Ilana Grach, Elad Attar, Naama Schwartz, Zeev Goldik, Arieh Eden   +6 more
doaj   +1 more source

Daily rhythm of nociception in rats

Journal of Circadian Rhythms, 2004
Background Many behavioral and physiological variables exhibit daily rhythmicity. Few investigations of the daily rhythmicity in nociception have been conducted, and conflicting results have been obtained.
Jayaprakash S, Vijaya C, Merlin NJ, Christina AJM, Murugesh N   +4 more
doaj   +1 more source

Disruption of persistent nociceptive behavior in rats with learning impairment. [PDF]

PLoS ONE, 2013
Despite the subjective nature of pain experience with cognitive and affective dimensions, preclinical pain research has largely focused on its sensory dimension.
Yuxin Ma, Shuxing Wang, Yinghong Tian, Lucy Chen, Guoying Li, Jianren Mao   +5 more
doaj   +1 more source

Capsaicin, Nociception and Pain [PDF]

Molecules, 2016
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved in somatic and visceral peripheral inflammation, in the modulation of nociceptive inputs to spinal cord and brain stem centers, as well as the integration of diverse ...
Frias, Bárbara, MERIGHI, Adalberto
openaire   +4 more sources

Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial

Anesthesiology, 2019
What We Already Know about This TopicThe nociception level index (Medasense Biometrics Ltd., Ramat Gan, Israel), is a reliable measure of moderate to intense noxious stimulation during anesthesia and surgery What This Article Tells Us That Is NewIn a ...
Fleur S. Meijer, C. Martini, S. Broens, M. Boon, M. Niesters, L. Aarts, E. Olofsen, Monique van Velzen, A. Dahan   +8 more
semanticscholar   +1 more source