Results 61 to 70 of about 88,386 (325)

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Angioni, Carlo Federico, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Marian, Claudiu, Pierre, Sandra, Popp, Laura, Schmidt, Helmut, Scholich, Klaus   +8 more
core   +1 more source

Lifting the veil on the keratinocyte contribution to cutaneous nociception

Protein & Cell, 2020
Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most ...
M. Talagas, N. Lebonvallet, F. Berthod, L. Miséry   +3 more
semanticscholar   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Evolution of nociception and pain: evidence from fish models

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019
In order to survive, animals must avoid injury and be able to detect potentially damaging stimuli via nociceptive mechanisms. If the injury is accompanied by a negative affective component, future behaviour should be altered and one can conclude the ...
L. Sneddon
semanticscholar   +1 more source

A Self‐Healing Magnetoelectric Sensor with Pain Sensing for Underwater Soft Electronics

Advanced Materials, EarlyView.
This study introduces a self‐healing magnetoelectric sensory system designed for amphibious soft electronics. By utilizing liquid‐metal conductors and self‐healing elastomers, the system enables autonomous recovery from mechanical damage. Its multilayered architecture features dual self‐powered proximity and tactile sensing alongside pain sensing in ...
Xuan Zhang, Jinrun Zhou, Pengyu Chen, Xuchen Wang, Eddy Yi Ler Pang, Bin Su, Yu Jun Tan   +6 more
wiley   +1 more source

Analgesia Nociception Index: assessment of acute postoperative pain [PDF]

Revista Brasileira de Anestesiologia
Background and objectives Patient self-rating based scales such as Numerical Rating Scale, Visual Analog Scale that is used for postoperative pain assessment may be problematic in geriatric or critically ill patients with communication problems. A method
Ruslan Abdullayev, Oznur Uludag, Bulent Celik   +2 more
doaj   +3 more sources

Investigating the electrical response of the brain of the domestic chicken (Gallus gallus domesticus) to nociception through the use of depth electroencephalography (dEEG) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Physiology at Massey University, Manawatū, New Zealand [PDF]

, 2015
Nociception is an unavoidable side effect of many routine management and clinical procedures in animals. Electroencephalography (EEG) has previously been used to investigate the effect of nociception on mammalian brain activity.
Trebilcock, Peter Dennis
core  

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Transcriptional reprogramming post-peripheral nerve injury: A systematic review

Neurobiology of Disease
Neuropathic pain is characterised by periodic or continuous hyperalgesia, numbness, or allodynia, and results from insults to the somatosensory nervous system.
R. Hayward, S. Moore, D. Artun, A. Madhavan, E. Harte, J.V. Torres-Pérez, I. Nagy   +6 more
doaj   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source