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Current Methods to Investigate Nociception and Pain in Zebrafish
Frontiers in Neuroscience, 2021 Pain is an unpleasant, negative emotion and its debilitating effects are complex to manage. Mammalian models have long dominated research on nociception and pain, but there is increasing evidence for comparable processes in fish.
Nils Ohnesorge +2 more
semanticscholar +1 more source
Wellcome Open Research, 2018 Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression
M.A. Bangash +17 more
doaj +1 more source
The ankyrin repeat domain of the TRPA protein painless is important for thermal nociception but not mechanical nociception. [PDF]
PLoS ONE, 2012 The Drosophila TRPA channel Painless is required for the function of polymodal nociceptors which detect noxious heat and noxious mechanical stimuli. These functions of Painless are reminiscent of mammalian TRPA channels that have also been implicated in ...
Richard Y Hwang +2 more
doaj +1 more source
Journal of Neuroinflammation, 2020 Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory system, contributing to pain exacerbation ...
Yongwoo Jang, Minseok Kim, S. Hwang
semanticscholar +1 more source
Leptin and fractalkine: novel subcutaneous cytokines in burn injury
Disease Models & Mechanisms, 2020 Burn injury is a pathology underpinned by progressive and aberrant inflammation. It is a major clinical challenge to survival and quality of life. Although the complex local and disseminating pathological processes of a burn injury ultimately stem from ...
Dominic Friston +7 more
doaj +1 more source
Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics [PDF]
, 2020 The use of zebrafish larvae has aroused wide interest in the medical field for its potential role in the development of new therapies. The larvae grow extremely quickly and the embryos are nearly transparent which allows easy examination of its internal ...
Jiang, Hui-Rong +13 more
core +2 more sources
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
The role of cGMP and PKG-I in spinal nociceptive processing [PDF]
, 2005 First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia.
Geisslinger, Gerd +5 more
core +1 more source
Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms
Cell Reports, 2014 Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain.
Michael S. Minett +6 more
doaj +1 more source
Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]
, 2010 Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Wijnvoord, Nina +5 more
core +2 more sources