Results 21 to 30 of about 14,156 (228)

Linkage between increased nociception and olfaction via a SCN9A haplotype [PDF]

, 2013
Background and Aims: Mutations reducing the function of Nav1.7 sodium channels entail diminished pain perception and olfactory acuity, suggesting a link between nociception and olfaction at ion channel level.
Hummel, Thomas, Bruno G Oertel, Lötsch, Jörn, Thomas Hummel, Jörn Lötsch, Doehring, Alexandra, Dirk Heimann, Heimann, Dirk, Alexandra Doehring, Oertel, Bruno Georg   +9 more
core   +2 more sources

Nociception monitoring [PDF]

, 2022
This thesis concentrates on nociception monitoring during general anesthesia. Nociception is the process of encoding noxious stimuli, which are potential damaging events.
Meijer, F.S.
core  

Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms

Cell Reports, 2014
Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain.
Michael S. Minett, Sarah Falk, Sonia Santana-Varela, Yury D. Bogdanov, Mohammed A. Nassar, Anne-Marie Heegaard, John N. Wood   +6 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira, Queensta Millet, Jose Aramburu, Cristina Lopez-Rodriguez, Claire Gaveriaux-Ruff, John N. Wood   +5 more
doaj   +1 more source

A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?

İstanbul Journal of Pharmacy, 2022
Pain is sensed by the activation of painful nociceptors in the periphery or by pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from the damaged tissue, afferent transmission to the medulla spinalis, and by trans- mission stages to the high centers over the dorsal horn. Pain, which was seen as only a warning sign in
EKEN, Hazal, BEKTAŞ TÜRKMEN, Nurcan, ARSLAN, Rana   +2 more
openaire   +4 more sources

Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice. [PDF]

PLoS ONE, 2015
The sensory thalamus has been reported to play a key role in central pain sensory modulation and processing, but its response to repeated nociception at thalamic level is not well known.
Yeowool Huh, Jeiwon Cho
doaj   +1 more source

The Role of Na1.9 Channel in the Development of Neuropathic Orofacial Pain Associated with Trigeminal Neuralgia

Molecular Pain, 2015
Background Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG).
Ana Paula Lulz, Olga Kopach, Sonia Santana-Varela, John N. Wood   +3 more
doaj   +1 more source

Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex

Nature Communications, 2022
The processing of nociception in the somatosensory cortex (S1) has yet to be fully understood. Here, the authors demonstrate that the dysgranular region in S1 has an affinity for nociception and is critically involved in pain-like behavior.
Hironobu Osaki, Moeko Kanaya, Yoshifumi Ueta, Mariko Miyata   +3 more
doaj   +1 more source

Nociception-related somatosensory evoked potentials in awake dogs recorded after intra epidermal electrical stimulation [PDF]

, 2009
Eur J Pain. 2009 Feb;13(2):154-60. Epub 2008 May 16. Nociception-related somatosensory evoked potentials in awake dogs recorded after intra epidermal electrical stimulation. van Oostrom H, Stienen PJ, Doornenbal A, Hellebrekers LJ. Department of Clinical
Advances in Veterinary Medicine, Doornenbal, Arie, Arie Doornenbal, Hellebrekers, L.J., van Oostrom, H., Stienen, Peter J, Hellebrekers, Ludo J, van Oostrom, Hugo, Doornenbal, A., Peter J. Stienen, Ludo J. Hellebrekers, Stienen, P.J., Hugo van Oostrom, Dep Gezondheidszorg Paard   +13 more
core   +1 more source