Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain
JOR SPINE, Volume 8, Issue 3, September 2025.This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann +18 more
wiley +1 more source
Nociplastic pain: exploring the concept and ongoing discussions. [PDF]
Korean J PainQuintner J, Weisman A, Cohen M.
europepmc +1 more source
Animal models and peripheral nociception tests for the study of neuropathic pain.
, 2001 Hiroshi Ueda, Makoto Inoue
openalex +2 more sources
Vagal modulation of nociception is mediated by adrenomedullary epinephrine in the rat [PDF]
, 2003 Sachia G. Khasar +3 more
openalex +1 more source
Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective
JOR SPINE, Volume 8, Issue 3, September 2025.This review of surgically induced IVD puncture injury animal models presents an evolution over decades to include many variations simulating distinct clinical phenotypes of IVDD, and recommends reporting a common set of injury features to facilitate cross‐study comparison.
Charu Jain +8 more
wiley +1 more source
The Analgesia Nociception Index's Performance During Remimazolam-Based General Anesthesia: A Prospective Observational Study. [PDF]
Medicina (Kaunas)Lee J, Yi JM, Joo Y.
europepmc +1 more source
JOR SPINE, Volume 8, Issue 3, September 2025.This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose +4 more
wiley +1 more source
Opioid-free anesthesia in craniotomy - Current evidence and Gaps in implementation. [PDF]
Brain SpineKutum C, Lakhe P.
europepmc +1 more source
Zebrafish as a Versatile Model Organism: From Tanks to Treatment
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava +9 more
wiley +1 more source
Effects of experimentally induced lumbar nociception on trunk motor control in the rat during locomotion. [PDF]
Exp Brain ResXiao F +5 more
europepmc +1 more source