Comparison of the qCON and qNOX indices for the assessment of unconsciousness level and noxious stimulation response during surgery [PDF]
, 2016 The objective of this work is to compare the performances of two electroencephalogram based indices for detecting loss of consciousness and loss of response to nociceptive stimulation.
Agustí, Mercé +8 more
core +2 more sources
Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics [PDF]
, 2020 The use of zebrafish larvae has aroused wide interest in the medical field for its potential role in the development of new therapies. The larvae grow extremely quickly and the embryos are nearly transparent which allows easy examination of its internal ...
Jiang, Hui-Rong +13 more
core +2 more sources
Journal of Neuroinflammation, 2020 Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory system, contributing to pain exacerbation ...
Yongwoo Jang, Minseok Kim, S. Hwang
semanticscholar +1 more source
The para<sup>bss1</sup> Drosophila melanogaster as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects. [PDF]
Eur J PainABSTRACT Background Chronic pain, which is often unrelated to ongoing injury, is poorly understood and difficult to treat. Genetic studies have identified voltage‐gated sodium (Nav) channels, particularly gain‐of‐function mutations such as L858F and R1150W in human NaV1.7, as involved in the development of chronic pain. Methods A chronic pain model was
Malta SM +7 more
europepmc +2 more sources
An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]
, 2013 Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present
Alves-Filho, J.C. +9 more
core +3 more sources
Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms
Cell Reports, 2014 Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain.
Michael S. Minett +6 more
doaj +1 more source
Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]
, 2010 An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier +49 more
core +2 more sources
Wellcome Open Research, 2018 Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira +5 more
doaj +1 more source
Comparison of clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with acute non compressive nucleus pulposus extrusion [PDF]
, 2016 OBJECTIVE To compare clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with presumptive acute noncompressive nucleus pulposus extrusion (ANNPE). DESIGN Retrospective study. ANIMALS 51 dogs with ischemic myelopathy and
De Decker, S +3 more
core +3 more sources
Mechanisms of microbial–neuronal interactions in pain and nociception
Neurobiology of Pain, 2020 Valentina N. Lagomarsino +2 more
openalex +2 more sources