Results 101 to 110 of about 49,496 (354)

Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]

, 2015
Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine, Ramachandran, Roshni, Yaksh, Tony L   +2 more
core   +2 more sources

Hell's Itch: An Acute Reaction to Sunburn Exposure

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a neurocutaneous dysesthesia following sunburn that is underreported in scientific literature despite considerable discussion online. ‘Hell's itch’ describes an acute, uncontrollable itch with intense stabbing pain several days post‐sunburn and often follows an inciting event such as water exposure.
Colin Kelly, Connor Stonesifer, Brian W. Morrison   +2 more
wiley   +1 more source

Pain threshold assessment in relation to neural mobilization therapy = Avaliação do limiar de dor frente à terapia com mobilização neural [PDF]

Acta Scientiarum. Health Sciences, 2012
Nervous System Mobilization is used to restore the biomechanics of the nervous system and adjacent structures, promoting the return to their duties. This study evaluated the pain threshold to pressure, to cold, and the cold pain intensity in healthy ...
Anaíma Lopes Frutos, Bruna Fomentão Araújo, Edson Antonio Alves da Silva, Gladson Ricardo Flor Bertolini   +3 more
doaj   +1 more source

Clinical features for diagnosis and management of patients with PRDM12 congenital insensitivity to pain. [PDF]

, 2016
BACKGROUND: Congenital insensitivity to pain (CIP) is a rare extreme phenotype characterised by an inability to perceive pain present from birth due to lack of, or malfunction of, nociceptors.
Ahmed, Mushtaq, Bennett, Christopher, Chen, Ya-Chun, Sharif, Saghira Malik, Sheridan, Eamonn, Valente, Enza-Maria, Woods, Geoffrey, Zhang, Stella   +7 more
core   +3 more sources

Ultrasound‐Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu, Li‐Juan Liu, Fa‐Ming Xu, Xiang‐Yu Fang   +3 more
wiley   +1 more source

PAIN AND INFLAMMATION. PART 1. PATHOGENETIC ASPECTS

Научно-практическая ревматология, 2017
The relief of suffering, which is associated with a rapid and complete elimination of painful sensations, is the most important challenge facing physicians of many specialties.
A. E. Karateev, D. E. Karateev, O. S. Davydov   +2 more
doaj   +1 more source

TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione [PDF]

, 2016
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of ...
Benemei, Silvia, Coppi, Elisabetta, De Logu, Francesco, Di Tommaso, Mariarosaria, Fusi, Camilla, Geppetti, Pierangelo, Li Puma, Simone, Marone, Ilaria M., Materazzi, Serena, Moneti, Gloriano, Morice, Alyn H., Nassini, Romina, Sadofsky, Laura R., Susini, Tommaso, Terreni, Alessandro, Tonello, Raquel   +15 more
core   +1 more source

Exercise intolerance and fatigue in chronic heart failure: is there a role for group III/IV afferent feedback? [PDF]

, 2020
Exercise intolerance and early fatiguability are hallmark symptoms of chronic heart failure. While the malfunction of the heart is certainly the leading cause of chronic heart failure, the patho-physiological mechanisms of exercise intolerance in these ...
Angius, Luca, Crisafulli, Antonio
core   +2 more sources

Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain

Pain, 2018
Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain, and on OA generated in non-nociceptive A&bgr; fibers rather than C-fiber ...
Max A. Odem, A. Bavencoffe, Ryan M. Cassidy, E. R. Lopez, Jinbin Tian, C. Dessauer, E. Walters   +6 more
semanticscholar   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source