Results 41 to 50 of about 3,343 (187)
European Journal of PsychotraumatologyBackground: This study investigates the psychological underpinnings of chronic pain conditions, specifically fibromyalgia, chronic headache, vulvodynia, and mixed condition (consisting of fibromyalgia in comorbidity with chronic headache and/or ...
Martina Mesce +4 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota +14 more
wiley +1 more source
The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review [PDF]
Exploration of ImmunologyNociplastic pain is the fourth category of pain defined in recent years. It is a pain arising from altered nociception, despite the lack of clear evidence of actual or threatened tissue damage that causes activation of peripheral nociceptors nor evidence
Mariateresa Giglio +4 more
doaj +1 more source
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.A multimodal intervention including supervised exercise, pelvic floor muscle training, and pain management was associated with modest short‐term improvements in sexual function among women with endometriosis. Findings should be interpreted cautiously due to differences in sexual activity status between groups.
Rakel Gabrielsen +4 more
wiley +1 more source
Part of pain labelled neuropathic in rheumatic disease might be rather nociplastic
RMD Open, 2020 Pain in rheumatic diseases is primarily due to mechanical or inflammatory mechanism, but neuropathic pain (NP) component is also occurring in many conditions and is probably underdiagnosed.
Alain Cantagrel +9 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Retrospective Analysis of Functional Pain among Professional Climbers
Applied Sciences, 2022 Climbing became one of the official Olympic sports in 2020. The nociplastic pain mechanism is indicated as important in professional sports. Functional pain, which has not been examined in climbers until now, can be an example of nociplastic pain.
Matuska Jakub +7 more
doaj +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux +26 more
wiley +1 more source
Contemporary Clinical Trials CommunicationsBackground: Chronic pain is the leading cause of disability and disease burden globally. Emerging evidence suggests that people with nociplastic dominant chronic pain commonly have heightened pain sensitivity, high levels of pain interference and low ...
Jon Ford +4 more
doaj +1 more source