Results 61 to 70 of about 3,343 (187)

Nociplastic pain among individuals with chronic ocular surface pain: one cause for “pain without stain”? [PDF]

Chronic ocular surface pain (COSP) refers to interrelated symptoms such as burning, aching, and irritation and can occur as an isolated condition or comorbid with numerous ocular disorders, including dry eye syndrome Treatments for COSP are largely aimed
Galor, Anat, Kaplan, Chelsea, De Lott, Lindsey B., Clauw, Daniel J., Vehof, Jelle, Harte, Steven, Shtein, Roni M.   +6 more
core   +1 more source

The posterior capsular central amygdala showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice

iScience
Summary: Projections from the external lateral parabrachial nucleus (elPB) to the central amygdala (CeA) are a key pathway for nociceptive signals and play a crucial role in establishing nociplastic pain sensitization, a state of heightened pain without ...
Takao Okuda, Sawako Uchiyama, Naoko Sato, Yae K. Sugimura, Yukari Takahashi, Makoto Tsuda, Fusao Kato   +6 more
doaj   +1 more source

Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain

The Journal of Physiology, EarlyView.
Abstract figure legend Patients with fibromyalgia (FM) and no‐pain controls completed questionnaire‐based ratings of chronic pain, childhood trauma, anxiety and depression. Brief touch stimuli were then administered, including slow brushing at the C‐tactile optimal velocity of 3 cm/s, deep oscillating pressure with a compression sleeve, roboticized ...
Benedetta Albinni, Marisa Zimmerman, Vincent Alasha, Jacob Ross, Lindsey Crankshaw, Sandy R. Hu, Nathaniel Schuster, Laura Case   +7 more
wiley   +1 more source

Pain in Inflammatory and Degenerative Joint Diseases

Journal of Clinical Rheumatology and Immunology
The International Association for the Study of Pain (IASP) agreed in 2020 on a revised definition of pain: “An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage”.
Hilde Berner Hammer
doaj   +1 more source

Disability, Fatigue and Mental Health in Acute Versus Chronic Spinal Pain in the Gaza Strip: A Comparative Cross‐Sectional Study

Musculoskeletal Care, Volume 24, Issue 4, December 2026.
ABSTRACT Background Spinal pain is a major contributor to disability, but evidence comparing multidomain outcomes across acute and chronic stages remains limited in conflict‐affected settings. This study aimed to compare disability, fatigue, psychological distress and sleep disturbance among patients with acute and chronic neck pain and low back pain ...
Marwa Salama, Ahmed A. Najim, Magdy Shabana, Reham Almukbel, Kinan Mokbel   +4 more
wiley   +1 more source

Pregabalin and Duloxetine in Patients with Non-Nociceptive Pain: A Narrative Review Exploring the Pharmacological Effects of This Combination

Pharmaceuticals
Both neuropathic and nociplastic pain (non-nociceptive pain) are characterized by a similar pattern of clinical symptoms, including numbness, dysesthesia, tingling, and pricking.
Gianmarco Marcianò, Maurizio Evangelista, Cristina Vocca, Vincenzo Rania, Caterina Palleria, Maria Cristina Caroleo, Riccardo Torta, Luca Gallelli   +7 more
doaj   +1 more source

Association of Vitamin B6 and Homocysteine–ACTH Coupling With Depressive and Anxiety Symptoms in Burning Mouth Syndrome: An Exploratory Case–Control Study

Journal of Oral Rehabilitation, Volume 53, Issue 11, Page 2053-2063, November 2026.
In this exploratory case–control study, plasma PLP (vitamin B6), homocysteine and ACTH concentrations did not differ between patients with burning mouth syndrome (BMS) and controls, and none discriminated patients individually. Within patients, however, psychological distress mapped onto a homocysteine–ACTH relationship from which PLP appeared ...
Ashley Lebel, Charlotte Guillouet, André Porporatti, Yves Boucher   +3 more
wiley   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm
Chronic pain imposes incalculable health and economic burdens, affecting more than 30% of the global population in published studies. Optimal management of chronic pain is imperative for individuals experiencing such distress.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
doaj   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Measuring muscle tone and pain in children with cerebral palsy: Pain that does not interfere is still pain

Developmental Medicine &Child Neurology, EarlyView.
Sarah Kim, Edward Hurvitz
wiley   +1 more source