Results 1 to 10 of about 4,015 (236)

LC-MS/MS Analysis of Cyanotoxins in Bivalve Mollusks—Method Development, Validation and First Evidence of Occurrence of Nodularin in Mussels (Mytilus edulis) and Oysters (Magallana gigas) from the West Coast of Sweden [PDF]

Toxins, 2023
In this paper, an LC-MS/MS method for the simultaneous identification and quantification of cyanotoxins with hydrophilic and lipophilic properties in edible bivalves is presented.
Julio César España Amórtegui, Heidi Pekar, Mark Dennis Chico Retrato, Malin Persson, Bengt Karlson, Jonas Bergquist, Aida Zuberovic-Muratovic   +6 more
doaj   +3 more sources

Nodularin-R Synergistically Enhances Abiraterone Against Castrate- Resistant Prostate Cancer via PPP1CA Inhibition. [PDF]

J Cell Mol Med
Clinically, most prostate cancer (PCa) patients inevitably progress to castration‐resistant prostate cancer (CRPC) with poor prognosis after androgen deprivation therapy (ADT), including abiraterone, the drug of choice for ADT. Therefore, it is necessary
Huang Y, Cen Y, Wu H, Zeng G, Su Z, Zhang Z, Feng S, Jiang X, Wei A.   +8 more
europepmc   +3 more sources

Evaluating the Potential Inhibition of PP2A by Nodularin-R Disinfection By-Products: Effect and Mechanism [PDF]

Toxins
The secondary contamination of nodularin disinfection by-products (NOD-DBPs) is a problem worthy of attention. In this study, prototypical NOD-R-DBPs were prepared, and their toxicity was assessed using conventional protein phosphatase (PPs) inhibition ...
Mengchen Li, Chunyu Fu, Qiannan Shi, Shaocong Yang, Wansong Zong   +4 more
doaj   +3 more sources

Biotransformation Is an Effective Mechanism for Modulating the Biological Toxicity of Nodularin (NODR) [PDF]

Toxins
The biotransformation of nodularin (NOD) is one of the critical strategies for regulating their biological toxicity. To investigate the effects and mechanisms of the biotransformation pathway, this study synthesized six biotransformation products of ...
Chunyu Fu, Mengchen Li, Qiannan Shi, Yixue Xu, Wansong Zong   +4 more
doaj   +3 more sources

First report of nodularin production by Nostochopsis sp. in a temperate eutrophic lake. [PDF]

Harmful Algae
Benthic cyanobacteria are understudied in comparison to their planktonic counterparts. Consequently, our understanding of cyanotoxin production in benthic mats remains limited.
Webster AM, Triumph Z, Wei B, Martin RM, Smith LE, Wilhelm SW, Cleckner LB, Razavi NR, Boyer GL.   +8 more
europepmc   +2 more sources

Preparation of Specific Nanobodies and Their Application in the Rapid Detection of Nodularin-R in Water Samples

Foods, 2021
Nanobodies have several advantages, including great stability, sensibility, and ease of production; therefore, they have become important tools in immunoassays for chemical contaminants.
Jinyi Yang, Rui Si, Guangpei Wu, Yu Wang, Ruyu Fang, Fei Liu, Feng Wang, Hongtao Lei, Yudong Shen, Qi Zhang, Hong Wang   +10 more
doaj   +2 more sources

Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin

Biosensors, 2019
Cyanobacterial blooms cause local and global health issues by contaminating surface waters. Microcystins and nodularins are cyclic cyanobacterial peptide toxins comprising numerous natural variants.
Sultana Akter, Teemu Kustila, Janne Leivo, Gangatharan Muralitharan, Markus Vehniäinen, Urpo Lamminmäki   +5 more
doaj   +2 more sources

Detection and Characterization of Nodularin by Using Label-Free Surface-Enhanced Spectroscopic Techniques. [PDF]

Int J Mol Sci, 2022
Nodularin (NOD) is a potent toxin produced by Nodularia spumigena cyanobacteria. Usually, NOD co-exists with other microcystins in environmental waters, a class of cyanotoxins secreted by certain cyanobacteria species, which makes identification ...
Brezeștean IA, Gherman AMR, Colniță A, Dina NE, Müller Molnár C, Marconi D, Chiș V, David IL, Cîntă-Pînzaru S.   +8 more
europepmc   +2 more sources

Simultaneous Detection and Quantification of Aflatoxin M1, Eight Microcystin Congeners and Nodularin in Dairy Milk by LC-MS/MS

Chemosensors, 2023
Dairy milk holds a prominent position as a widely consumed food, particularly among infants and children. However, it is crucial to address the presence of multiple natural toxic compounds that may co-occur in dairy milk to ensure its safety prior to ...
Camille Van Camp, Wannes Hugo R. Van Hassel, Mohamed F. Abdallah, Julien Masquelier   +3 more
doaj   +2 more sources

Biodegradation of Nodularin by a Microcystin-Degrading Bacterium: Performance, Degradation Pathway, and Potential Application

Toxins, 2021
Currently, studies worldwide have comprehensively recognized the importance of Sphingomonadaceae bacteria and the mlrCABD gene cluster in microcystin (MC) degradation. However, knowledge about their degradation of nodularin (NOD) is still unclear.
Mengxuan Yuan, Qin Ding, Rongli Sun, Juan Zhang, Lihong Yin, Yuepu Pu   +5 more
doaj   +2 more sources