Results 21 to 30 of about 1,721 (197)
Nodularin-R Synergistically Enhances Abiraterone Against Castrate- Resistant Prostate Cancer via PPP1CA Inhibition. [PDF]
J Cell Mol MedABSTRACT Clinically, most prostate cancer (PCa) patients inevitably progress to castration‐resistant prostate cancer (CRPC) with poor prognosis after androgen deprivation therapy (ADT), including abiraterone, the drug of choice for ADT. Therefore, it is necessary to explore the resistance mechanism of abiraterone in depth.
Huang Y +8 more
europepmc +2 more sources
Shipin gongye ke-ji, 2022 A method was developed for the determination of nodularin (NOD) in algae-based health food by ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-MS/MS). The analytes were extracted from algae-based health food powder
Shuo LI, Li LI
doaj +1 more source
Solution Structure of Nodularin [PDF]
Journal of Biological Chemistry, 1996 The three-dimensional solution structure of nodularin was studied by NMR and molecular dynamics simulations. The conformation in water was determined from the distance and dihedral data by distance geometry and refined by iterative relaxation matrix analysis. The cyclic backbone adopts a well defined conformation but the remote parts of the side chains
Arto Annila +6 more
openaire +3 more sources
Frontiers in Microbiology, 2021 Toxin-producing cyanobacteria can be harmful to aquatic biota, although some grazers utilize them with often beneficial effects on their growth and reproduction. It is commonly assumed that gut microbiota facilitates host adaptation to the diet; however,
Elena Gorokhova +3 more
doaj +1 more source
Shifts in DNA yield and biological community composition in stored sediment: implications for paleogenomic studies [PDF]
Metabarcoding and Metagenomics, 2022 Lake sediments hold a wealth of information from past environments that is highly valuable for paleolimnological reconstructions. These studies increasingly apply modern molecular tools targeting sedimentary DNA (sedDNA).
Katie A. Brasell +8 more
doaj +3 more sources
Congener-Independent Immunoassay for Microcystins and Nodularins [PDF]
Environmental Science & Technology, 2001 Cyanobacteria (blue-green algae) (e.g., Microcystis and Nodularia spp.) capable of producing toxic peptides are found in fresh and brackish water worldwide. These toxins include the microcystin (MC) heptapeptides (>60 congeners) and the nodularin pentapeptides (ca. 5 congeners).
Fischer, Werner Jürgen +7 more
openaire +3 more sources
Microorganisms, 2022 (1) Background: Cyanobacteria produce a wide range of secondary metabolites, including tumor-promoting hepatotoxins. We recently reported evidence of an independent association between oral cyanobacteria and hepatocellular carcinoma in a U.S. population.
Brenda Y. Hernandez +6 more
doaj +1 more source
Cell Death Inducing Microbial Protein Phosphatase Inhibitors—Mechanisms of Action
Marine Drugs, 2015 Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death.
Rune Kleppe +2 more
doaj +1 more source
Frontiers in Microbiology, 2021 Cyanobacteria of the order Nostocales, including Baltic Sea bloom-forming taxa Nodularia spumigena, Aphanizomenon flosaquae, and Dolichospermum spp., produce resting stages, known as akinetes, under unfavorable conditions.
Steffaney M. Wood +6 more
doaj +1 more source
Marine Drugs, 2018 In the Baltic Sea, diazotrophic cyanobacteria have been present for thousands of years, over the whole brackish water phase of the ecosystem. However, our knowledge about the species composition of the cyanobacterial community is limited to the last ...
Marta Cegłowska +3 more
doaj +1 more source