Results 21 to 30 of about 1,531 (204)
Nodularin-R Synergistically Enhances Abiraterone Against Castrate- Resistant Prostate Cancer via PPP1CA Inhibition. [PDF]
J Cell Mol MedABSTRACT Clinically, most prostate cancer (PCa) patients inevitably progress to castration‐resistant prostate cancer (CRPC) with poor prognosis after androgen deprivation therapy (ADT), including abiraterone, the drug of choice for ADT. Therefore, it is necessary to explore the resistance mechanism of abiraterone in depth.
Huang Y +8 more
europepmc +2 more sources
Solution Structure of Nodularin [PDF]
Journal of Biological Chemistry, 1996 The three-dimensional solution structure of nodularin was studied by NMR and molecular dynamics simulations. The conformation in water was determined from the distance and dihedral data by distance geometry and refined by iterative relaxation matrix analysis. The cyclic backbone adopts a well defined conformation but the remote parts of the side chains
Arto Annila +6 more
openaire +3 more sources
Congener-Independent Immunoassay for Microcystins and Nodularins [PDF]
Environmental Science & Technology, 2001 Cyanobacteria (blue-green algae) (e.g., Microcystis and Nodularia spp.) capable of producing toxic peptides are found in fresh and brackish water worldwide. These toxins include the microcystin (MC) heptapeptides (>60 congeners) and the nodularin pentapeptides (ca. 5 congeners).
Fischer, Werner Jürgen +7 more
openaire +3 more sources
Nodularin concentrations produced by Nodularia [PDF]
, 2018 Nodularin concentrations from water samples belonging from water from beakers in which Daphnia were reared.
Naomi Huntley (6108521) +7 more
core +1 more source
Cell Death Inducing Microbial Protein Phosphatase Inhibitors—Mechanisms of Action
Marine Drugs, 2015 Okadaic acid (OA) and microcystin (MC) as well as several other microbial toxins like nodularin and calyculinA are known as tumor promoters as well as inducers of apoptotic cell death.
Rune Kleppe +2 more
doaj +1 more source
Frontiers in Microbiology, 2021 Cyanobacteria of the order Nostocales, including Baltic Sea bloom-forming taxa Nodularia spumigena, Aphanizomenon flosaquae, and Dolichospermum spp., produce resting stages, known as akinetes, under unfavorable conditions.
Steffaney M. Wood +6 more
doaj +1 more source
Dominance and toxicity without lethality: Exploring biomass, cyanometabolites, and Daphnia responses across Cyanobacterial strains. [PDF]
J PhycolAbstract Cyanobacteria are cosmopolitan, important components of biomass with a remarkable ability to synthesize a diverse array of bioactive compounds, some of which may have toxic effects on other organisms and ecosystems. In this study, filamentous cyanobacterial strains isolated predominantly from temperate European freshwaters (Aphanizomenon ...
Wejnerowski Ł +14 more
europepmc +2 more sources
Marine Drugs, 2018 In the Baltic Sea, diazotrophic cyanobacteria have been present for thousands of years, over the whole brackish water phase of the ecosystem. However, our knowledge about the species composition of the cyanobacterial community is limited to the last ...
Marta Cegłowska +3 more
doaj +1 more source
Blooms of Toxic Cyanobacterium Nodularia spumigena in Norwegian Fjords During Holocene Warm Periods
Toxins, 2020 In paleoecological studies, molecular markers are being used increasingly often to reconstruct community structures, environmental conditions and ecosystem changes.
Robert Konkel +6 more
doaj +1 more source
Associations of cyanobacterial toxin, nodularin, with environmental factors and zooplankton in the Baltic Sea [PDF]
, 2004 Concentrations of a cyanobacterial toxin, nodularin, were measured in the Baltic Sea in 1998 and 1999. Statistical associations of nodularin concentrations with environmental factors were tested by multiple regression analysis.
Sivonen, K. +3 more
core +1 more source