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Apoptotic responses of Carassius auratus lymphocytes to nodularin exposure in vitro
Fish and Shellfish Immunology, 2012Nodularin, a metabolite of Nodularin spumigena, is widely detected in water blooms worldwide and causes serious negative effects on fish. The apoptosis-related cytotoxic effects and mechanisms of nodularin on Carassius auratus lymphocytes were investigated.
Hangjun Zhang
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Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity
Journal of Cancer Research and Clinical Oncology, 1990Microcystins and nodularin, isolated from toxic blue-green algae, are hepatotoxic monocyclic polypeptides. Both microcystins and nodularin inhibited in vitro protein phosphatase activity present in a cytosolic fraction of mouse liver, bound to the okadaic acid receptors, protein phosphatases 1 and 2A, and thus resulted in the increase of ...
Hirota Fujiki +2 more
exaly +3 more sources
Cloud-point extraction of nodularin-R from natural waters
Analytica Chimica Acta, 2004 A cloud-point extraction (CPE) technique for the determination of a cyanobacterial hepatotoxin, nodularin-R, in aqueous media using a cationic surfactant, tricaprylmethylammonium chloride (Aliquat-336), was developed.
Kwan Sing Paul Lam, Wah Michael Lam
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Suppression of IL-2 and IL-4 gene expression by nodularin through the reduced NF-AT binding activity
Toxicology Letters, 2000 Nodularin is a cyclic peptide produced by cyanobacteria. In the present study, the inhibitory effect of nodularin on T lymphocyte functions was demonstrated.
Hee-Mock Oh, Hye Gwang Jeong, Y J Jeon
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Nodularin, a cyanobacterial toxin, is synthesized in planta by symbiotic Nostoc sp.
ISME Journal, 2012 The nitrogen-fixing bacterium, Nostoc, is a commonly occurring cyanobacterium often found in symbiotic associations. We investigated the potential of cycad cyanobacterial endosymbionts to synthesize microcystin/nodularin.
Brett Anthony Neilan +2 more
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Clinica Chimica Acta, 2013
Nodularins are an important class of hepatotoxic cyclic pentapeptides that are produced by the cyanobacteria Nodularia spumigena. These peptides have been found worldwide and have been implicated in the deaths of animals as well as a potent cyanotoxin in humans.
Yun, Chen, Danfeng, Shen, Danjun, Fang
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Nodularins are an important class of hepatotoxic cyclic pentapeptides that are produced by the cyanobacteria Nodularia spumigena. These peptides have been found worldwide and have been implicated in the deaths of animals as well as a potent cyanotoxin in humans.
Yun, Chen, Danfeng, Shen, Danjun, Fang
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Comprehensive insights into the occurrence and toxicological issues of nodularins
Marine Pollution Bulletin, 2021The occurrence of cyanobacterial toxins is being increasingly reported. Nodularins (NODs) are one of the cyanotoxins group mainly produced by Nodularia spumigena throughout the world. NODs may exert adverse effects on animal and human health, and NOD-R variant is the most widely investigated. However, research focused on them is still limited. In order
Guoliang, Chen +3 more
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Nodularin-Har: A New Nodularin from Nodularia
Journal of Natural Products, 2000A cyanobacterial hepatotoxin, nodularin-Har, having a homoarginine instead of an arginine in nodularin, was isolated from Nodularia PCC7804. The structure was elucidated as 1 on the basis of 2D NMR and FABMS. The LD(50) (mouse ip) value of 1 was 70 microg/kg.
K, Saito +6 more
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Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-κB in HepG2 cells
Toxicology and Applied Pharmacology, 2011 Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin.
Bai, Yansheng +2 more
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Redox Mechanisms of Nodularin and Chemically Degraded Nodularin
Electroanalysis, 2011AbstractThe electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected ...
Paulina V. F. Santos +4 more
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