Results 161 to 170 of about 1,721 (197)

Bacterial Degradation of Microcystins and Nodularin

Chemical Research in Toxicology, 2005
Microcystins and nodularins produced by cyanobacteria are potent hepatotoxins and tumor promoters. They are, respectively, cyclic heptapeptides and cyclic pentapeptides containing a characteristic beta-amino acid residue, (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4(E ),6(E)-dienoic acid (Adda).
Susumu, Imanishi, Hajime, Kato, Masayoshi, Mizuno, Kiyomi, Tsuji, Ken-ichi, Harada   +4 more
openaire   +2 more sources

Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review

Journal of Environmental Science and Health, Part C, 2015
Cyanobacteria are present in all aquatic ecosystems throughout the world. They are able to produce toxic secondary metabolites, and microcystins are those most frequently found. Research has displayed a negative influence of microcystins and closely related nodularin on fish, and various histopathological alterations have been observed in many organs ...
Zorica, Svirčev, Jelena, Lujić, Zoran, Marinović, Damjana, Drobac, Nada, Tokodi, Bratislav, Stojiljković, Jussi, Meriluoto   +6 more
openaire   +2 more sources

Nodularin uptake by seafood during a cyanobacterial bloom

Environmental Toxicology, 2001
AbstractThe problem of blue‐green algal toxin contamination of recreational waters and drinking water catchments is well described, as is the potential contamination of associated seafood. Algal contamination of Victorian waterways is now a widespread annual occurrence and, in some regions, the intersection of blooms and commercial fishing threatens ...
P G, Van Buynder, T, Oughtred, B, Kirkby, S, Phillips, G, Eaglesham, K, Thomas, M, Burch   +6 more
openaire   +2 more sources

Lymphoid depletion in two dogs with nodularin intoxication

Veterinary Record, 2011
NODULARIN-related intoxications have been described in a variety of species, including dogs (Main and others 1977, Beasley and others 1989, van Halderen and others 1995, Duy and others 2000, van Apeldoorn and others 2007, Broker and others 2010). Nodularin is a potent hepatotoxin produced by the cyanobacterium Nodularia spumigena , which can be found ...
D, Algermissen, R, Mischke, F, Seehusen, J, Göbel, A, Beineke   +4 more
openaire   +2 more sources

Total Synthesis of Motuporin (Nodularin-V)

Journal of the American Chemical Society, 1999
The serine/threonine phosphatase (protein phosphatase 1 and 2A) inhibitors constitute a biologically and structurally interesting class of natural products. Among this class of inhibitors are cyclic pentapeptides (nodularins) and cyclic heptapeptides (microcystins), both of which inhibit at the nanomolar level and are the only peptide inhibitors of ...
Shawn M. Bauer, Robert W. Armstrong
openaire   +1 more source

Hydrolysis of microcystins and nodularin by microwave radiation

Chromatographia, 1999
Microwave radiation has been successfully used for hydrolysis of the hepatotoxic cyclic peptides microcystins and nodularin. Set-up of the microwave device and the operating conditions for microwave hydrolysis were optimized. Results of the microwave hydrolysis were compared with results from conventional hydrolysis for 24 h at 110°C.
M. Reichelt, C. Hummert, B. Luckas
openaire   +1 more source

Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

Journal of Chromatography B, 2003
Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 ...
Krister, Karlsson, Vesa, Sipiä, Harri, Kankaanpää, Jussi, Meriluoto   +3 more
openaire   +2 more sources

Extraction of 15 microcystins and nodularin using immunoaffinity columns

Toxicon, 2003
Microcystins (MCYSTs) were isolated from surface water using reusable immunoaffinity columns. Individual MCYST were determined by high performance liquid chromatography equipped with a photo-diode array detector (HPLC-PDA, 200-300 nm). Subsequent analysis of the samples by liquid chromatography-electrospray ionization mass spectrometry (LC-ESMS ...
Rocio, Aranda-Rodriguez, Cariton, Kubwabo, Frank M, Benoit   +2 more
openaire   +2 more sources

Detection of nodularin in flounders and cod from the Baltic Sea

Environmental Toxicology, 2001
AbstractThe brackish water cyanobacterium Nodularia spumigena regularly forms waterblooms in the Baltic Sea. Many N. spumigena strains can produce nodularin, a hepatotoxic penta‐peptide, which has caused several animal poisonings in the Baltic Sea area.
V, Sipiä, H, Kankaanpää, K, Lahti, W W, Carmichael, J, Meriluoto   +4 more
openaire   +2 more sources

Separation of microcystins and nodularins by ultra performance liquid chromatography

Journal of Chromatography B, 2009
Four ultra performance liquid chromatography (UPLC) columns with different reversed-phase characteristics were tested in the chromatographic separation of 10 microcystins and three nodularins, cyanobacterial peptide toxins. The columns had been designed by the manufacturer to withstand the ultra-high pressure generated by sub-2microm stationary phase ...
Lisa, Spoof, Milla-Riina, Neffling, Jussi, Meriluoto   +2 more
openaire   +2 more sources