Results 161 to 170 of about 3,166 (211)
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Biodegradation of microcystins and nodularin in freshwaters
Chemosphere, 2008Microcystin-LR (MC-LR) was readily biodegraded on addition to six different water samples irrespective of their previous exposure to microcystins. Subsequent studies with water from three of these water bodies confirmed the degradation of MC-LR and also demonstrated the biodegradation of MC-LF, nodularin and mixture of microcystins and nodularin. Rates
Christine N Edwards, Linda A Lawton
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Clinica Chimica Acta, 2013
Nodularins are an important class of hepatotoxic cyclic pentapeptides that are produced by the cyanobacteria Nodularia spumigena. These peptides have been found worldwide and have been implicated in the deaths of animals as well as a potent cyanotoxin in humans.
Yun, Chen, Danfeng, Shen, Danjun, Fang
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Nodularins are an important class of hepatotoxic cyclic pentapeptides that are produced by the cyanobacteria Nodularia spumigena. These peptides have been found worldwide and have been implicated in the deaths of animals as well as a potent cyanotoxin in humans.
Yun, Chen, Danfeng, Shen, Danjun, Fang
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Nodularin induced oxidative stress contributes to developmental toxicity in zebrafish embryos
Ecotoxicology and Environmental Safety, 2020 Nodularin (NOD) is a kind of cyanobacterial toxins. It is of concern due to elicit severe genotoxicity in humans and animals. The comprehensive evaluation of NOD-induced adverse effects in living organisms is urgently needed. This study is aimed to report the developmental toxicity and molecular mechanism using zebrafish embryos exposed to NOD.
Tingzhang Hu
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Harmful Algae, 2009
The brackish, bloom-forming cyanobacterium Nodularia spumigena produces a peptide called nodularin, which may induce liver damage in fish.
Catherine Legrand
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The brackish, bloom-forming cyanobacterium Nodularia spumigena produces a peptide called nodularin, which may induce liver damage in fish.
Catherine Legrand
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Nodularin-Har: A New Nodularin from Nodularia
Journal of Natural Products, 2000A cyanobacterial hepatotoxin, nodularin-Har, having a homoarginine instead of an arginine in nodularin, was isolated from Nodularia PCC7804. The structure was elucidated as 1 on the basis of 2D NMR and FABMS. The LD(50) (mouse ip) value of 1 was 70 microg/kg.
K, Saito +6 more
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Redox Mechanisms of Nodularin and Chemically Degraded Nodularin
Electroanalysis, 2011AbstractThe electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected ...
Paulina V. F. Santos +4 more
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Bacterial Degradation of Microcystins and Nodularin
Chemical Research in Toxicology, 2005Microcystins and nodularins produced by cyanobacteria are potent hepatotoxins and tumor promoters. They are, respectively, cyclic heptapeptides and cyclic pentapeptides containing a characteristic beta-amino acid residue, (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4(E ),6(E)-dienoic acid (Adda).
Susumu, Imanishi +4 more
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Nodularin uptake by seafood during a cyanobacterial bloom
Environmental Toxicology, 2001AbstractThe problem of blue‐green algal toxin contamination of recreational waters and drinking water catchments is well described, as is the potential contamination of associated seafood. Algal contamination of Victorian waterways is now a widespread annual occurrence and, in some regions, the intersection of blooms and commercial fishing threatens ...
P G, Van Buynder +6 more
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Total Synthesis of Motuporin (Nodularin-V)
Journal of the American Chemical Society, 1999The serine/threonine phosphatase (protein phosphatase 1 and 2A) inhibitors constitute a biologically and structurally interesting class of natural products. Among this class of inhibitors are cyclic pentapeptides (nodularins) and cyclic heptapeptides (microcystins), both of which inhibit at the nanomolar level and are the only peptide inhibitors of ...
Shawn M. Bauer, Robert W. Armstrong
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