Results 161 to 170 of about 1,531 (204)
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Bacterial Degradation of Microcystins and Nodularin
Chemical Research in Toxicology, 2005Microcystins and nodularins produced by cyanobacteria are potent hepatotoxins and tumor promoters. They are, respectively, cyclic heptapeptides and cyclic pentapeptides containing a characteristic beta-amino acid residue, (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4(E ),6(E)-dienoic acid (Adda).
Susumu, Imanishi +4 more
openaire +2 more sources
Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity
Journal of Cancer Research and Clinical Oncology, 1990Microcystins and nodularin, isolated from toxic blue-green algae, are hepatotoxic monocyclic polypeptides. Both microcystins and nodularin inhibited in vitro protein phosphatase activity present in a cytosolic fraction of mouse liver, bound to the okadaic acid receptors, protein phosphatases 1 and 2A, and thus resulted in the increase of ...
Ken-Ichi Harada +2 more
exaly +3 more sources
Comparative effects of nodularin and microcystin-LR in zebrafish: 1. Uptake by organic anion transporting polypeptide Oatp1d1 (Slco1d1) [PDF]
Aquatic Toxicology, 2016 Microcystin-LR (MC-LR) and nodularin are hepatotoxins produced by several cyanobacterial species. Their toxicity is based on active cellular uptake and subsequent inhibition of protein phosphatases PP1/2A, leading to hyperphosphorylation and cell death ...
Jakob Pernthaler, Karl Fent
exaly +2 more sources
Detection of nodularin in flounders and cod from the Baltic Sea
Environmental Toxicology, 2001AbstractThe brackish water cyanobacterium Nodularia spumigena regularly forms waterblooms in the Baltic Sea. Many N. spumigena strains can produce nodularin, a hepatotoxic penta‐peptide, which has caused several animal poisonings in the Baltic Sea area.
Jussi Meriluoto, W W Carmichael
exaly +5 more sources
Apoptotic responses of Carassius auratus lymphocytes to nodularin exposure in vitro
Fish and Shellfish Immunology, 2012Nodularin, a metabolite of Nodularin spumigena, is widely detected in water blooms worldwide and causes serious negative effects on fish. The apoptosis-related cytotoxic effects and mechanisms of nodularin on Carassius auratus lymphocytes were investigated.
Hangjun Zhang
exaly +3 more sources
Toxicopathology Induced by Microcystins and Nodularin: A Histopathological Review
Journal of Environmental Science and Health, Part C, 2015Cyanobacteria are present in all aquatic ecosystems throughout the world. They are able to produce toxic secondary metabolites, and microcystins are those most frequently found. Research has displayed a negative influence of microcystins and closely related nodularin on fish, and various histopathological alterations have been observed in many organs ...
Zorica, Svirčev +6 more
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Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-κB in HepG2 cells [PDF]
Toxicology and Applied Pharmacology, 2011 Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin.
Bai, Yansheng +2 more
exaly +1 more source
Lymphoid depletion in two dogs with nodularin intoxication
Veterinary Record, 2011NODULARIN-related intoxications have been described in a variety of species, including dogs (Main and others 1977, Beasley and others 1989, van Halderen and others 1995, Duy and others 2000, van Apeldoorn and others 2007, Broker and others 2010). Nodularin is a potent hepatotoxin produced by the cyanobacterium Nodularia spumigena , which can be found ...
D, Algermissen +4 more
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Nodularin uptake by seafood during a cyanobacterial bloom
Environmental Toxicology, 2001AbstractThe problem of blue‐green algal toxin contamination of recreational waters and drinking water catchments is well described, as is the potential contamination of associated seafood. Algal contamination of Victorian waterways is now a widespread annual occurrence and, in some regions, the intersection of blooms and commercial fishing threatens ...
P G, Van Buynder +6 more
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Hydrolysis of microcystins and nodularin by microwave radiation
Chromatographia, 1999Microwave radiation has been successfully used for hydrolysis of the hepatotoxic cyclic peptides microcystins and nodularin. Set-up of the microwave device and the operating conditions for microwave hydrolysis were optimized. Results of the microwave hydrolysis were compared with results from conventional hydrolysis for 24 h at 110°C.
M. Reichelt, C. Hummert, B. Luckas
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