Results 171 to 180 of about 1,531 (204)

Total Synthesis of Motuporin (Nodularin-V)

Journal of the American Chemical Society, 1999
The serine/threonine phosphatase (protein phosphatase 1 and 2A) inhibitors constitute a biologically and structurally interesting class of natural products. Among this class of inhibitors are cyclic pentapeptides (nodularins) and cyclic heptapeptides (microcystins), both of which inhibit at the nanomolar level and are the only peptide inhibitors of ...
Shawn M. Bauer, Robert W. Armstrong
openaire   +1 more source

Cytotoxic and immunological responses of fish leukocytes to nodularin exposure in vitro

Journal of Applied Toxicology, 2021
AbstractNodularin (NOD) is a cyclic peptide released by bloom‐forming toxic cyanobacteria Nodularia spumigena commonly occurring in brackish waters throughout the world. Although its hepatotoxic effects are well known, other negative effects of NOD have not yet been completely elucidated.
Anna Rymuszka, Anna Sieroslawska, Łukasz Adaszek   +2 more
openaire   +2 more sources

Mass spectrometric detection of nodularin and desmethylnodularin in mussels and flounders

Journal of Chromatography B, 2003
Samples of mussels and flounders from the Baltic Sea were analysed for nodularin content on two different LC-MS instruments (triple quadrupole and ion trap). The triple quadrupole instrument was well suited for the quantitative analysis. The limit of detection in the selected ion recording mode was 5 pg and in the multiple reactant monitoring mode 500 ...
Krister, Karlsson, Vesa, Sipiä, Harri, Kankaanpää, Jussi, Meriluoto   +3 more
openaire   +2 more sources

Extraction of 15 microcystins and nodularin using immunoaffinity columns

Toxicon, 2003
Microcystins (MCYSTs) were isolated from surface water using reusable immunoaffinity columns. Individual MCYST were determined by high performance liquid chromatography equipped with a photo-diode array detector (HPLC-PDA, 200-300 nm). Subsequent analysis of the samples by liquid chromatography-electrospray ionization mass spectrometry (LC-ESMS ...
Rocio, Aranda-Rodriguez, Cariton, Kubwabo, Frank M, Benoit   +2 more
openaire   +2 more sources

Separation of microcystins and nodularins by ultra performance liquid chromatography

Journal of Chromatography B, 2009
Four ultra performance liquid chromatography (UPLC) columns with different reversed-phase characteristics were tested in the chromatographic separation of 10 microcystins and three nodularins, cyanobacterial peptide toxins. The columns had been designed by the manufacturer to withstand the ultra-high pressure generated by sub-2microm stationary phase ...
Lisa, Spoof, Milla-Riina, Neffling, Jussi, Meriluoto   +2 more
openaire   +2 more sources

The degradation of the cyanobacterial hepatotoxin nodularin (NOD) by UV radiation

Chemosphere, 2006
This study investigates the decomposition of NOD by UV irradiation. Water solutions of pure NOD and NOD-containing Nodularia extract as well as Nodularia filaments collected on filters were exposed to UV-A, UV-B, and white fluorescent light (VIS) during 48 h experiments. In VIS, the toxin was fairly stable and only 3.8-4.6% of the original degraded. UV-
Hanna Mazur-Marzec, Meriluoto, Jussi, Marcin Pliński   +2 more
openaire   +2 more sources

Biodegradation and sorption of nodularin (NOD) in fine-grained sediments

Chemosphere, 2008
Nodularin (NOD) is a cyclic pentapeptide hepatotoxin produced by the bloom forming cyanobacterium Nodularia spumigena. The fate of the toxin in the aquatic environment has not been fully evaluated. In the current study the changes in NOD concentration caused by biodegradation and sorption in samples from the Baltic were studied.
Anna, Toruńska, Jerzy, Bolałek, Marcin, Pliński, Hanna, Mazur-Marzec   +3 more
openaire   +2 more sources

New Nodularins: A General Method for Structure Assignment

The Journal of Organic Chemistry, 1994
A general method has been developed for assigning the structures of nodularin, a potent hepatotoxin, tumor promoter, and protein phosphatase inhibitor, and minor components isolated from a cultured and a bloom sample of the cyanobacterium Nodularia spumigena.
Michio Namikoshi, Byoung Wook Choi, Ryuichi Sakai, Furong Sun, Kenneth L. Rinehart, Wayne W. Carmichael, William R. Evans, Phillip Cruz, Murray H. G. Munro, John W. Blunt   +9 more
openaire   +1 more source

The Microcystins and Nodularins: Cyclic Polypeptide Inhibitors of PP1 and PP2A

Current Medicinal Chemistry, 2002
The serine/threonine phosphatases are inhibited by a variety of natural toxins, including the microcystins and nodularins. Progress in understanding the details of the biosynthetic origin and the binding of these compounds is discussed, as is the progress made in synthesizing the members of these families.
B M, Gulledgea, J B, Aggena, H-B, Huangb, A C, Nairnc, A R, Chamberlin   +4 more
openaire   +2 more sources

Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells

Food and Chemical Toxicology, 2019
The cyanobacterial pentapeptide nodularin (NOD), mainly produced by genus Nodularia, is a potent inhibitor of protein phosphatases PP1 and PP2A, and causes animal mortality. The few studies available indicate that NOD is a potential non-genotoxic carcinogen.
A. Štern, A. Rotter, M. Novak, M. Filipič, B. Žegura   +4 more
openaire   +2 more sources