Results 171 to 180 of about 1,721 (197)

New Nodularins: A General Method for Structure Assignment

The Journal of Organic Chemistry, 1994
A general method has been developed for assigning the structures of nodularin, a potent hepatotoxin, tumor promoter, and protein phosphatase inhibitor, and minor components isolated from a cultured and a bloom sample of the cyanobacterium Nodularia spumigena.
Michio Namikoshi, Byoung Wook Choi, Ryuichi Sakai, Furong Sun, Kenneth L. Rinehart, Wayne W. Carmichael, William R. Evans, Phillip Cruz, Murray H. G. Munro, John W. Blunt   +9 more
openaire   +1 more source

A fluorescent immunochromatographic test using immunoliposomes for detecting microcystins and nodularins

Analytical and Bioanalytical Chemistry, 2009
Microcystins (MCs), a group of cyclic heptapeptides produced by common cyanobacteria (blue green algae), cause both acute and chronic toxicity. Due to their toxicity, constant monitoring in drinking water, recreational waters as well as other potential exposure through ingestion of contaminated sea food, is very important.
Khreich, Nathalie, Lamourette, Patricia, Lagoutte, Bernard, Ronco, Cyril, Franck, Xavier, Créminon, Christophe, Volland, Hervé   +6 more
openaire   +5 more sources

Biodegradation and sorption of nodularin (NOD) in fine-grained sediments

Chemosphere, 2008
Nodularin (NOD) is a cyclic pentapeptide hepatotoxin produced by the bloom forming cyanobacterium Nodularia spumigena. The fate of the toxin in the aquatic environment has not been fully evaluated. In the current study the changes in NOD concentration caused by biodegradation and sorption in samples from the Baltic were studied.
Anna Toruńska, Jerzy Bolałek, Marcin Pliński, Hanna Mazur-Marzec   +3 more
openaire   +2 more sources

The Microcystins and Nodularins: Cyclic Polypeptide Inhibitors of PP1 and PP2A

Current Medicinal Chemistry, 2002
The serine/threonine phosphatases are inhibited by a variety of natural toxins, including the microcystins and nodularins. Progress in understanding the details of the biosynthetic origin and the binding of these compounds is discussed, as is the progress made in synthesizing the members of these families.
B M, Gulledgea, J B, Aggena, H-B, Huangb, A C, Nairnc, A R, Chamberlin   +4 more
openaire   +2 more sources

Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells

Food and Chemical Toxicology, 2019
The cyanobacterial pentapeptide nodularin (NOD), mainly produced by genus Nodularia, is a potent inhibitor of protein phosphatases PP1 and PP2A, and causes animal mortality. The few studies available indicate that NOD is a potential non-genotoxic carcinogen.
A. Štern, A. Rotter, M. Novak, M. Filipič, B. Žegura   +4 more
openaire   +2 more sources

ChemInform Abstract: Nodularin, Microcystin, and the Configuration of Adda.

ChemInform, 1989
AbstractThe uniquely characteristic C20 amino acid Adda is present in closely related toxins reported recently such as microcystins (cyanoginosins; all cyclic heptapeptides), e.g. microcystin LR (I) (presumably identical with cyanoginosin LR).
K. L. RINEHART, K. HARADA, M. NAMIKOSHI, C. CHEN, C. A. HARVIS, M. H. G. MUNRO, J. W. BLUNT, P. E. MULLIGAN, V. R. BEASLEY, A. M. DAHLEM, W. W. CARMICHAEL   +10 more
openaire   +1 more source

Heterogeneity of nodularin bioaccumulation in northern Baltic Sea flounders in 2002

Chemosphere, 2005
The cyanobacterial hepatotoxin nodularin is abundantly produced by the cyanobacterium Nodularia spumigena in the Baltic Sea during July-August. Nodularin is a potent hepatotoxin and a tumour promoter, distributed in various Baltic Sea environmental compartments, especially food webs involving mussels.
H, Kankaanpää, A-K, Turunen, K, Karlsson, G, Bylund, J, Meriluoto, V, Sipiä   +5 more
openaire   +2 more sources

Uptake and accumulation of dissolved, radiolabeled nodularin in Baltic Sea zooplankton

Environmental Toxicology, 2003
AbstractThe mass occurrence of toxic cyanobacteria is a recurrent phenomenon in the Baltic Sea. Grazers may obtain toxins either through ingestion or by direct exposure to dissolved toxins. Despite this, there is little knowledge about the accumulation of cyanobacterial toxins in planktonic organisms present during these blooms.
M, Karjalainen, M, Reinikainen, F, Lindvall, L, Spoof, J A O, Meriluoto   +4 more
openaire   +2 more sources

Nodularin from benthic freshwater periphyton and implications for trophic transfer

Toxicon, 2017
In 2013 and 2015, the Pennsylvania Department of Environmental Protection conducted a survey of lotic habitats within the Susquehanna, Delaware, and Ohio River basins in Pennsylvania, USA, to screen for microcystins/nodularins (MCs/NODs) in algae communities and smallmouth bass (Micropterus dolomieu). Periphyton (68 from 41 sites), juvenile whole fish (
Amanda J. Foss, Jeffery Butt, Sarah Fuller, Kamil Cieslik, Mark T. Aubel, Tim Wertz   +5 more
openaire   +2 more sources

Biodegradation of nodularin and other nonribosomal peptides by the Baltic bacteria

International Biodeterioration & Biodegradation, 2018
Microcystins (MCs) and nodularin (NOD), the hepatotoxic nonribosomal peptides (NRPs) produced by cyanobacteria, are considered as natural pollutants of many aquatic ecosystems. Removal of the toxins proceeds mainly through biodegradation and/or photolysis.
Anna Toruńska-Sitarz, Ewa Kotlarska, Hanna Mazur-Marzec   +2 more
openaire   +1 more source