Results 171 to 180 of about 4,015 (236)

Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells

Food and Chemical Toxicology, 2019
The cyanobacterial pentapeptide nodularin (NOD), mainly produced by genus Nodularia, is a potent inhibitor of protein phosphatases PP1 and PP2A, and causes animal mortality. The few studies available indicate that NOD is a potential non-genotoxic carcinogen.
A. Štern   +4 more
openaire   +3 more sources

Extraction and analysis by liquid chromatography - tandem mass spectrometry of intra- and extracellular microcystins and nodularin to study the fate of cyanobacteria and cyanotoxins across the freshwater-marine continuum.

Toxicon, 2023
The presence of microcystins (MCs) is increasingly being reported in coastal areas worldwide. To provide reliable data regarding this emerging concern, reproducible and accurate methods are required to quantify MCs in salt-containing samples.
D. Réveillon   +6 more
semanticscholar   +1 more source

Toxicological response of Pacific white shrimp Litopenaeus vannamei to a hazardous cyanotoxin nodularin exposure.

Environmental Pollution, 2022
Nodularin (NOD) is a harmful cyanotoxin that affects shrimp farming. The hepatopancreas and intestine of shrimp are the main target organs of cyanotoxins. In this study, we exposed Litopenaeus vannamei to NOD at 0.1 and 1 μg/L for 72 h, respectively, and
Yafei Duan   +5 more
semanticscholar   +1 more source

Nodularins in poisoning

Clinica Chimica Acta, 2013
Nodularins are an important class of hepatotoxic cyclic pentapeptides that are produced by the cyanobacteria Nodularia spumigena. These peptides have been found worldwide and have been implicated in the deaths of animals as well as a potent cyanotoxin in humans.
Yun, Chen, Danfeng, Shen, Danjun, Fang
openaire   +2 more sources

Nodularin-Har:  A New Nodularin from Nodularia

Journal of Natural Products, 2000
A cyanobacterial hepatotoxin, nodularin-Har, having a homoarginine instead of an arginine in nodularin, was isolated from Nodularia PCC7804. The structure was elucidated as 1 on the basis of 2D NMR and FABMS. The LD(50) (mouse ip) value of 1 was 70 microg/kg.
K, Saito   +6 more
openaire   +2 more sources

Redox Mechanisms of Nodularin and Chemically Degraded Nodularin

Electroanalysis, 2011
AbstractThe electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected ...
Paulina V. F. Santos   +4 more
openaire   +1 more source

Home - About - Disclaimer - Privacy