Pharmacokinetic and pharmacodynamic drug-drug interaction of Nomilin with atorvastatin in hyperlipidemic mice [PDF]
Heliyon, 2023 Atorvastatin (Atv) is widely used to lower cholesterol levels and treat hyperlipidemia in clinical application. Nomilin (Nom) is a kind of limonoids, which is found and isolated from the citrus herbs of Rutaceae family, which are widely used as patent ...
Yan Ding +4 more
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Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway [PDF]
Antioxidants, 2022 Yuzu (Citrus junos) is a citrus plant native to Asian countries, including Korea, Japan, and China. Yuzu peel and seed contain abundant vitamin C, citric acid, and polyphenols.
Moon-Hee Choi +2 more
exaly +4 more sources
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions [PDF]
Nature Communications, 2023 Citrus fruit has long been considered a healthy food, but its role and detailed mechanism in lifespan extension are not clear. Here, by using the nematode C.
Shengjie Fan +20 more
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Nomilin and Its Analogues in Citrus Fruits: A Review of Its Health Promotion Effects and Potential Application in Medicine [PDF]
Molecules, 2022 Nomilin is one of the major limonoids, which are plant secondary metabolites also known as tetranortriterpenoids. Nomilin is found mostly in common edible citrus fruits including lemons, limes, oranges, grapefruits, mandarins, along with traditional ...
Zhenyu Zhou +5 more
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Coumarins, furocoumarins and limonoids of Citrus trifoliata and their effects on human colon adenocarcinoma cell lines [PDF]
Heliyon, 2022 Citrus trifoliata L. (Chinese or Japanese bitter orange) is a medicinal plant with furocoumarins and limonoids as characteristic secondary metabolites.
Diána Kerekes +6 more
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Isolation and bioactivities of nomilin from citrus family: a review
Journal of Future FoodsNomilin is a type of limonoid primarily found in citrus fruits. It is a triterpenoid compound that has gained significant attention recently due to its diverse biological activities.
Wei Li +8 more
exaly +4 more sources
Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer [PDF]
Molecular MedicineBackground Nomilin is a limonoid compound known for its multiple biological activities, but its role in triple negative breast cancer (TNBC) remains unclear. This study aims to uncover the potential therapeutic effect of nomilin on TNBC and elucidate the
Zhixuan Wu +7 more
doaj +2 more sources
Structure-Based Insights into TGR5 Activation by Natural Compounds: Therapeutic Implications and Emerging Strategies for Obesity Management [PDF]
BiomedicinesTGR5 has emerged as a promising therapeutic target for obesity and metabolic disorders due to its regulatory roles in energy expenditure, glucose homeostasis, thermogenesis, and gut hormone secretion.
Dong Oh Moon
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Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models. [PDF]
Antioxidants (Basel), 2021 The COVID-19 pandemic represents an unprecedented global emergency. Despite all efforts, COVID-19 remains a threat to public health, due to the complexity of mass vaccination programs, the lack of effective drugs, and the emergence of new variants.
Magurano F +12 more
europepmc +3 more sources
BMC Complementary and Alternative Medicine, 2010 Background Several cell culture and animal studies demonstrated that citrus bioactive compounds have protective effects against certain types of cancer.
Ahmad Hassan +5 more
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