Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model. [PDF]
PLoS ONE, 2017 TGR5, a member of the G protein-coupled receptor (GPCR) family, is activated by bile acids. Because TGR5 promotes energy expenditure and improves glucose homeostasis, it is recognized as a key target in treating metabolic diseases.
Takashi Sasaki +9 more
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Nomilin targets the Keap1‐Nrf2 signalling and ameliorates the development of osteoarthritis [PDF]
Journal of Cellular and Molecular Medicine, 2020 AbstractOsteoarthritis (OA) is a long‐term and inflammatory disorder featured by cartilage erosion. Here, we describe nomilin (NOM), a triterpenoid with inflammation modulatory properties in variety of disorders. In this study, we demonstrated the latent mechanism of NOM in alleviating the progress of OA both in vitro and in vivo studies.
Xing-He Xue, Yang Yang
exaly +3 more sources
Citrus limonoid nomilin inhibits osteoclastogenesis in vitro by suppression of NFATc1 and MAPK signaling pathways [PDF]
Phytomedicine, 2015 Animal experiment studies have revealed a positive association between intake of citrus fruits and bone health. Nomilin, a limonoid present in citrus fruits, is reported to have many biological activities in mammalian systems, but the mechanism of nomilin on bone metabolism regulation is currently unclear.To reveal the mechanism of nomilin on ...
Yoshifumi, Kimira +9 more
exaly +3 more sources
Assessment of the in vitro anti-diabetic activity with molecular dynamic simulations of limonoids isolated from Adalia lemon peels [PDF]
Scientific ReportsLimonoids are important constituents of citrus that have a significant impact on promoting human health. Therefore, the primary focus of this research was to assess the overall limonoid content and isolate limonoids from Adalia lemon (Citrus limon L ...
Amal M. El-Feky +2 more
doaj +2 more sources
Temporal and spatial variations on accumulation of nomilin and limonin in the pummelos
Plant Physiology and Biochemistry, 2016 Limonoids are the important secondary metabolites in the citrus. In this study, the accumulation of limonoids at different fruit developmental stages and distribution among different genotypes, tissues and developmental stages were investigated in 12 pummelo varieties. The large variations on limonoids concentration were found among different varieties,
Fusheng Wang
exaly +4 more sources
Effect of Huanglongbing or Greening Disease on Orange Juice Quality, a Review [PDF]
Frontiers in Plant Science, 2019 Huanglongbing (HLB) or citrus greening is the most severe citrus disease, currently devastating the citrus industry worldwide. The presumed causal bacterial agent Candidatus Liberibacter spp. affects tree health as well as fruit development, ripening and
Bruno M. Dala-Paula +6 more
doaj +4 more sources
Effects of rootstocks and developmental time on the dynamic changes of main functional substances in 'Orah' (<i>Citrus reticulata</i> Blanco) by HPLC coupled with UV detection. [PDF]
Front Plant SciIntroductionCitrus fruit is rich in important functional constituents such as flavonoids, phenolic acids terpenes and other functional substances that play an important role for treating clinical diseases or controlling major agricultural diseases and ...
Li S +9 more
europepmc +3 more sources
Chinese Herbal Medicines, 2017 Abstract Objective Nomilin and obacunone are two important limonoids that are well known for their anticancer effect. Previous studies showed that limonoids had inhibitory effect on cytochrome P450 3A4 (CYP3A4). However these effects are inconclusive with regards to prediction of potential drug interactions.
Yao-wen Fan +6 more
exaly +2 more sources
Correction: Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer [PDF]
Molecular MedicineZhixuan Wu +7 more
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Chemical profile of persian lime seeds (Citrus Limettioides T.): Focus on limonoids and polyphenols [PDF]
Anais da Academia Brasileira de Ciências, 2023 Citrus fruit industrial processing generates tons of waste composed of peels, seeds and pulp. Incorrect disposal of these residues may harm the environment.
TAIRINI R. DA SILVA +1 more
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