Results 151 to 160 of about 801 (182)

Nomilin Alleviates Neuroinflammation and Depressive-like Behaviors in Mice through the Upregulation of TAX1BP1-Mediated Modulation of Microglia Polarization

ACS Chemical Neuroscience
Nomilin is a limonoid compound that is found in citrus fruits. However, their functions remain to be further studied. The present study mainly analyzed the antineuroinflammation and antidepressive function of nomilin. The antidepressant and antineuroinflammatory effects of nomilin were examined in a mouse model induced by lipopolysaccharide (LPS), and ...
Xiaohong Pan, Zhipeng Li
exaly   +3 more sources

Nomilin Acetyl‐Lyase, a Bacterial Enzyme for Nomilin Debittering of Citrus Juices

Journal of Food Science, 1985
ABSTRACT Nomilin acetyl‐lyase, an enzyme responsible for the conversion of bitter nomilin to nonbitter obacunone was purified from cell‐free extracts of Corynebacterium fuscians by (NH 4 ) 2 SO
ZAREB HERMAN, SHIN HASEGAWA, PETER OU
openaire   +1 more source

Nomilin, Taste Threshold and Relative Bitterness

Journal of Food Science, 1984
ABSTRACT Aqueous taste thresholds for nomilin, a bitter citrus limonoid, were established by a combination of ascending series and sensory difference (triangle) tests. Results from the 25‐member screened panel indicated a detection or stimulus threshold of 0.8 ppm and a recognition threshold of 2.1 ppm.
R. L. ROUSEFF, R. F. MATTHEWS
openaire   +1 more source

Calorimetric Evidence of Differentiated Transport of Limonin and Nomilin through Biomembranes

Journal of Agricultural and Food Chemistry, 2000
The effect exerted by two structurally similar limonoids possessing antifeedant and anticancer activity, limonin and nomilin, on the thermotropic behavior of model membranes constituted by dimyristoylphosphatidylcholine (DMPC) vesicles was studied by differential scanning calorimetry.
CASTELLI, Francesco, Giuffrida N, TRINGALI, Corrado, Ruberto G.   +3 more
openaire   +4 more sources

Evaluation of the Antioxidant Capacity of Limonin, Nomilin, and Limonin Glucoside

Journal of Agricultural and Food Chemistry, 2006
The antioxidant capacity (AOC) of three representative citrus limonoids, limonin, nomilin, and limonin glucoside, was examined by the oxygen radical absorbance capacity (ORAC), Trolox equivalent antioxidant capacity (TEAC), beta-carotene-linoleic acid bleaching, and 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assays.
Andrew P, Breksa, Gary D, Manners
openaire   +2 more sources

Nomilin Attenuates Lipopolysaccharide-Induced Inflammatory Response by Binding with Myeloid Differentiation Protein-2

Combinatorial Chemistry & High Throughput Screening, 2023
Background: Nomilin shows anti-inflammatory activity by inhibiting the activation of the Toll-like receptor 4 (TLR 4)/NF-κB pathway. However, the key target of the anti-inflammatory activity of nomilin has not been elaborated and needs further exploration.
Yuting, Chen, Song, Guo, Guirong, Chen, Chang, Liu, Mingbo, Zhang, Xiaobo, Wang   +5 more
openaire   +2 more sources

Biosynthesis of obacunone from nomilin in Citrus limon

Phytochemistry, 1985
Abstract Radioactive tracer work showed that [14C]nomilin was converted to at least four metabolites in Citrus limon. One metabolite was identified as obacunone, showing that obacunone is biosynthesized from nomilin in C. limon.
Shin Hasegawa, Zareb Herman
openaire   +1 more source

Cytochrome P450 3A4-Mediated Bioactivation and Its Role in Nomilin-Induced Hepatotoxicity

Chemical Research in Toxicology, 2020
Nomilin is a furan-containing triterpenoid isolated from the medicinal plants of citrus. The aim of this study was to investigate the in vitro and in vivo bioactivation of nomilin and the role in nomilin-induced hepatotoxicity. Microsomal incubations of nomilin supplemented with NADPH and GSH or NAL resulted in the detection of six conjugates (M1-M6 ...
Lei Zhang, Qingwang Liu, Yajuan Pan, Xianfang Qi, Yuanlong Li, Ci Chen, Jun Sun   +6 more
openaire   +2 more sources

Nomilin as an Anti-Obesity and Anti-Hyperglycemic Agent

2013
Recent scientific findings support the notion that bile acids, which are cholesterol catabolites, are bioactive signaling molecules that function as ligands for the farnesoid X receptor or a G-protein-coupled receptor, TGR5. Through these receptors, bile acids can maintain not only bile acid homeostasis but also lipid and carbohydrate homeostasis.
openaire   +2 more sources

Nomilin mitigates OBS-induced developmental cardiotoxicity via the Nrf2 pathway

Aquatic Toxicology
Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is widely used in industry as a replacement for perfluorooctanesulfonic acid (PFOS) and has attracted considerable attention due to its environmental persistence and toxicity. However, limited information is available regarding its effects and underlying mechanisms in aquatic organisms, particularly ...
Xing, Liu, Yi, Fan, Ruobing, Chen, Yuting, Peng, Xinyi, Wu, Mingzhu, Xia, Yichun, Zhao, Junjie, Han, Man, Qu   +8 more
openaire   +2 more sources