Results 101 to 110 of about 135,541 (324)

An umbrella review of the effectiveness of fiscal and pricing policies on food and non‐alcoholic beverages to improve health [PDF]

open access: hybrid, 2023
Luke E. Barry   +8 more
openalex   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee   +5 more
wiley   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo   +7 more
wiley   +1 more source

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Pablo Salcedo   +11 more
wiley   +1 more source

Association of moderate beer consumption with the gut microbiota

open access: yesFood Science and Human Wellness
Beer is a fermented beverage prepared from water, malted barley, hops, and yeast that has been around for centuries. Alcoholic beverages alter the composition of the gut microbiota, which in turn causes oxidative stress brought on by alcohol, increases ...
Zhaoxi Liu   +5 more
doaj   +1 more source

Super Unleaded Malbec? A Case Study in Flawed International Standard Setting at the Codex Alimentarius [PDF]

open access: yes, 2019
The World Trade Organization’s (WTO) Agreement on the Application of Sanitary and Phytosanitary Measures (SPS Agreement) provides rules on the adoption and enforcement of SPS measures.
Schwegel, Justin
core   +2 more sources

Purpose and Profit: Social and Environmental Marketing for Large Companies in Adverse Scenarios

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This qualitative study explored how large companies use social and environmental marketing to boost results in adverse scenarios, analyzing interviews with marketing managers and public documents. The findings reveal distinct strategies. To attract investors, environmental, social, and governance (ESG) communication is targeted at limited ...
Celso Jacubavicius   +4 more
wiley   +1 more source

Vanillin production from lignin depolymerization by acidic deep eutectic solvent and its possible mechanism

open access: yesEnvironmental Progress &Sustainable Energy, EarlyView.
Abstract As one of the most abundant renewable resources and complex aromatic polymers, lignin holds great promise for producing monophenolic compounds. However, its depolymerization into valuable monomers is hindered by intricate side reactions. In this study, alkaline lignin was converted into vanillin using nine choline chloride‐based deep eutectic ...
Xiaoyan Chen, Xiaohui Pan, Dongyang Cui
wiley   +1 more source

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