Results 121 to 130 of about 171,267 (292)

Association between non-high-density lipoprotein cholesterol and non-alcoholic fatty liver disease among people living with HIV on dolutegravir-based antiretroviral therapy: A cross-sectional study in Southwestern Uganda

BMC Research Notes
Objective Non-high-density lipoprotein cholesterol, an aggregate marker of atherogenic lipoproteins, has been implicated in metabolic dysfunction and may predict non-alcoholic fatty liver disease risk.
Charles Nkubi Bagenda, Carol Nantongo, Elastus Ssemwanga, Michael Junior Mugisa, Jesca Wafwoyo Akoth, Daniel Nzaramba, Rogers Kalyetsi, Elizabeth A. John, Jazira Tumusiime, Blendar Ainebyoona, Shadrach Omara, Vicent Mwesigye, Sylvia Achieng Lumumba, Conrad Lubwama, Benson Musinguzi, Lucas Ampaire, Rose Nassali, Herbert Itabangi, Lawrence Obado Osuwat, Brian Ssenkumba, Ronald Ouma Omolo   +20 more
doaj   +1 more source

Sex-specific effect of dietary fatty acids on non-alcoholic fatty liver disease

Frontiers in Nutrition
BackgroundNon-alcoholic fatty liver disease is the most common chronic hepatic disease worldwide. Dietary fatty acid is tightly associated with the development of non-alcoholic fatty liver disease but few large-scale and in-depth clinical researches have
Jianhua Chen, Zeqin Zhang, Yuning Pan, Jiejun Shi   +3 more
doaj   +1 more source

Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

Liver Research, 2018
Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver ...
Bilon Khambu, Shengmin Yan, Nazmul Huda, Gang Liu, Xiao-Ming Yin   +4 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Influence of Hyperhomocysteinemia on Development of Non-Alcoholic Fatty Liver Disease in Diabetes Mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
In 137 patients with diabetes mellitus, non-alcoholic fatty liver disease and with combination of these diseases there had been studied the pathogenetic mechanisms of hyperhomocysteinemia influence on formation of non-alcoholic fatty liver disease.
A.V. Vlasenko
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

BMC Microbiology
Background Emerging evidence suggests that the gut microbiome plays a key role in metabolic diseases such as non-alcoholic fatty liver disease, yet the contribution of the gut mycobiome remains largely overlooked.
Ning Zheng, Dangrang Wang, Guorui Xing, Yidan Gao, Shenghui Li, Jin Liu, Jian Kang, Shanshan Sha, Lin Cheng, Shao Fan, Jian Yu, Qiulong Yan, Chunmeng Jiang   +12 more
doaj   +1 more source

Correlation Between Apolipoprotein B (Apob) Level and Non Alcoholic Fatty Liver in Type 2 Diabetes Mellitus with Metabolic Syndrome [PDF]

, 2011
Background: Non-alcoholic fatty liver disease (NAFLD) is a liver disorder commonly found in the majority of patients with metabolic risk factors, such as obesity and type 2 diabetes.
Harmono, T. (Tantoro), Nugroho, T. (Tejo), Pramana, T. Y. (Tri), Sugiarto, S. (Sugiarto)   +3 more
core   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial [PDF]

, 2016
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic disorder worldwide, reaching prevalence up to 90 % in obese patients with type 2 diabetes (T2D), and representing an independent risk factor for cardiovascular mortality ...
ANGELICO, Francesco, BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CATALANO, Carlo, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, DEL BEN, Maria, DI MARTINO, MICHELE, FRAIOLI, Antonio, LA TORRE, Giuseppe, Morini, Sergio, PANIMOLLE, FRANCESCA, PERRI, LUDOVICA, SAULLE, ROSELLA, TIBERTI, Claudio   +15 more
core   +2 more sources