Results 241 to 250 of about 81,538 (273)

Collagen-targeted protein nanomicelles for the imaging of non-alcoholic steatohepatitis. [PDF]

Acta Biomater
Wang AL, Mishkit O, Mao H, Arivazhagan L, Dong T, Lee F, Bhattacharya A, Renfrew PD, Schmidt AM, Wadghiri YZ, Fisher EA, Montclare JK.   +11 more
europepmc   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

A Novel GLP-1 and FGF21 Fusion Protein for the Treatment of Non-alcoholic Steatohepatitis (NASH). [PDF]

Adv Pharm Bull
Zhang Z, Ma Y, Xie C, He Y, Wang D, Song H, Yuan M, Zhang X.   +7 more
europepmc   +1 more source

Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong, Wanyan Tan, Ze Jin, Xiangyu Li, Yuting Chen, Wanting Xie   +5 more
wiley   +1 more source

Non-Alcoholic Steatohepatitis Patient Characterization and Real-World Management Approaches in Italy. [PDF]

Pragmat Obs Res
Bugianesi E, Miele L, Donnarumma G, Grau K, Mancuso M, Prasad P, Leith A, Higgins V.   +7 more
europepmc   +1 more source

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Multiple machine learning algorithms identify 13 types of cell death-critical genes in large and multiple non-alcoholic steatohepatitis cohorts. [PDF]

Lipids Health Dis
Jiang R, Dai L, Xu X, Zhang Z.
europepmc   +1 more source

Protective Effects of Myrtus communis Essential Oil Against Bisphenol A‐Induced Metabolic Dysfunction‐Associated Fatty Liver Disease in Wistar Rats

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Exposure to bisphenol A (BPA) induced hepatic steatosis associated with metabolic dysfunction (MASLD) in Wistar rats, characterized by dyslipidemia, oxidative stress, and hepatic steatosis. Co‐treatment with essential oil of myrtus communis (EOMC) improved markers of liver function, lipid profile, and antioxidant status, with histological improvement ...
Mhimdi Mariem, Selmi Slimen, Amira Zammali, Manel Hraoui, Soumaya Wahabi, Dallacqua Stefano, Sebai Hichem   +6 more
wiley   +1 more source

A Comparative Study of N-Acetyl Cysteine, Rosuvastatin, and Vitamin E in the Management of Patients with Non-Alcoholic Steatohepatitis: A Randomized Controlled Trial. [PDF]

Pharmaceuticals (Basel)
Zakaria AY, Badawi R, Osama H, Abdelrahman MA, El-Kalaawy AM.   +4 more
europepmc   +1 more source

Nonalcoholic Fatty Liver Disease Status and Its Associated Factors Among Patients With Type 2 Diabetes Mellitus in Adama Hospital Medical College, South Eastern Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Nonalcoholic fatty liver disease (NAFLD) is a condition of fat accumulation in hepatocytes, not because of excess alcohol intake and disease‐causing etiology. The disease occurrence is increased among patients with type 2 diabetes mellitus (T2DM) because of a strong pathophysiological link.
Mahider Shimelis Feyisa, Sintayehu Ambachew, Alemie Fentie Mebratie, Bruktawit Eshetu Ali, Rishan Hadgu Asefa, Elias Chane Asefa, Mahder Girma Asmamaw, Getnet Fetene   +7 more
wiley   +1 more source