Genotyping of B and Non-B Subtypes of Human Immunodeficiency Virus Type 1 [PDF]
ABSTRACT Current HIV-1 genotyping assays were developed using subtype B viruses prevalent in Western countries. It is not clear whether these assays are appropriate for use among African patients, who are likely to be infected with non-B subtypes.
C Y W, Tong +5 more
openaire +2 more sources
Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration [PDF]
Background The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.Methods and ...
Wynhoven, B +123 more
core +2 more sources
Performance of drug resistance assays in testing HIV-1 non-B subtypes [PDF]
Antiretroviral susceptibility analyses were performed in plasma samples collected from 32 HIV-1 non-B-infected individuals, most of whom had received antiretroviral drugs. Reverse transcriptase (RT) and protease gene sequences were obtained, and 15 anti-HIV drugs were tested in a recombinant virus phenotypic assay.
Holguín, Á., Hertogs, K., Soriano, V.
openaire +2 more sources
Mammographic density and molecular subtypes of breast cancer. [PDF]
BACKGROUND: Gene expression profiling has led to a subclassification of breast cancers independent of established clinical parameters, such as the Sorlie-Perou subtypes.
Bergh, J +21 more
core +1 more source
Background: Non-Hodgkin lymphoma (NHL) is a heterogeneous disease with respect to etiology, morphology, immunohistochemistry, and prognosis. Diffuse large B-cell lymphoma (DLBCL) is categorized into two subtypes – germinal center B-cell like (GCB) and ...
Gaurav Pal +2 more
doaj +1 more source
Background Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan Africa and India although they have been found worldwide. In the last decade, immigration from these areas has increased considerably in Spain.
Leal Manuel +10 more
doaj +1 more source
HIV-1 pol mutation frequency by subtype and treatment experience: extension of the HIVseq program to seven non-B subtypes [PDF]
HIVseq was developed in 2000 to make published data on the frequency of HIV-1 group M protease and reverse transcriptase (RT) mutations available in real time to laboratories and researchers sequencing these genes. Because most published protease and RT sequences belonged to subtype B, the initial version of HIVseq was based on this subtype.
Soo-Yon, Rhee +9 more
openaire +2 more sources
Virologic and immunologic response to cART by HIV-1 subtype in the CASCADE collaboration.
BackgroundWe aimed to compare rates of virologic response and CD4 changes after combination antiretroviral (cART) initiation in individuals infected with B and specific non-B HIV subtypes.MethodsUsing CASCADE data we analyzed HIV-RNA and CD4 counts for ...
Giota Touloumi +12 more
doaj +1 more source
Circulating Trends of Non-B HIV Type 1 Subtypes Among Kenyan Individuals [PDF]
As the AIDS pandemic progresses, an increasingly broad range of genetic diversity continues to be reported within the main (M) group of HIV-1 viruses with viral subtype predominating in specific geographic areas. To determine the genetic diversity of HIV-1 subtypes among Kenyan individuals, the env
Nyamache, A. K. +2 more
openaire +2 more sources
Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes. [PDF]
The single amino acid replacement Asp116His distinguishes the two subtypes HLA-B*2705 and HLA-B*2709 which are, respectively, associated and non-associated with Ankylosing Spondylitis, an autoimmune chronic inflammatory disease.
Elisa Nurzia +8 more
doaj +1 more source

