Results 11 to 20 of about 11,400,092 (255)

Non-Canonical Amino Acids in Analyses of Protease Structure and Function [PDF]

International Journal of Molecular Sciences, 2023
All known organisms encode 20 canonical amino acids by base triplets in the genetic code. The cellular translational machinery produces proteins consisting mainly of these amino acids.
Nediljko Budisa, Peter Goettig, Nikolaj Georg Koch   +2 more
exaly   +6 more sources

Microbial production of non‐canonical amino acids [PDF]

Microbial Biotechnology, 2023
Lawrence P. Wackett
doaj   +3 more sources

Beyond the Canonical 20: Peptide Discovery with Non-Canonical Amino Acids [PDF]

CHIMIA
Amino acids are central to biology as signaling molecules and as the building blocks of peptides and proteins, which represent an expanding class of drugs with vast therapeutic potential.
Nathalie M. Grob
doaj   +4 more sources

Editorial: Exploring and expanding the protein universe with non-canonical amino acids [PDF]

Frontiers in Molecular Biosciences, 2023
Gustavo Fuertes, Kensaku Sakamoto, Nediljko Budisa   +2 more
doaj   +4 more sources

Harnessing Transaminases to Construct Azacyclic Non-Canonical Amino Acids [PDF]

Nature Synthesis, 2023
Non-canonical amino acids (ncAAs) are prized building blocks in the synthesis of natural products, designer peptides and drug molecules. Despite their general utility, the complex structure of these molecules still presents an enormous challenge for ...
Hans, Renata, Tsung-Han, Chao, Xiangyu, Wu, Yu, Fu, Licheng, Yang   +4 more
core   +3 more sources

AAindexNC: Estimating the Physicochemical Properties of Non-Canonical Amino Acids, Including Those Derived from the PDB and PDBeChem Databank [PDF]

International Journal of Molecular Sciences
The physicochemical properties of amino acid residues from the AAindex database are widely used as predictors in building models for predicting both protein structures and properties.
Yury Kravatsky
exaly   +3 more sources

Non-canonical amino acids in protein engineering

Current Opinion in Biotechnology, 2003
Methods for engineering proteins that contain non-canonical amino acids have advanced rapidly in the past few years. Novel amino acids can be introduced into recombinant proteins in either a residue-specific or site-specific fashion.
Mock, Marissa L., Link, A. James, Tirrell, David A.   +2 more
core   +4 more sources

Use of non‐canonical amino acids in genetic code expansion‐based therapeutics: Effects on mouse gut microbiota [PDF]

Microbial Biotechnology, 2023
Vaccines and cell therapeutics based on genetic code expansion are emerging. A crucial step in these therapeutic technologies is the oral administration of non‐canonical amino acids (ncAAs) to control pathogen growth and therapeutic protein levels in ...
Manyu Liang, Yanhong Yang, Jing Zhang, Yingjie Sun, Haixia Peng, Huawei Yi, Qin Wang, Xiaowei Gao   +7 more
doaj   +2 more sources

Cell-Free Approach for Non-canonical Amino Acids Incorporation Into Polypeptides [PDF]

Frontiers in Bioengineering and Biotechnology, 2020
Synthetic biology holds promise to revolutionize the life sciences and biomedicine via expansion of macromolecular diversity outside the natural chemical space.
Zhenling Cui, Wayne A. Johnston, Kirill Alexandrov   +2 more
doaj   +4 more sources

Rationally introducing non-canonical amino acids to enhance catalytic activity of LmrR for Henry reaction [PDF]

Bioresources and Bioprocessing
The use of enzymes to catalyze Henry reaction has advantages of mild reaction conditions and low contamination, but low enzyme activity of promiscuous catalysis limits its application.
Lan Wang, Mengting Zhang, Haidong Teng, Zhe Wang, Shulin Wang, Pengcheng Li, Jianping Wu, Lirong Yang, Gang Xu   +8 more
doaj   +2 more sources