Results 41 to 50 of about 210,904 (138)

An Alternative Model of Amino Acid Replacement [PDF]

, 2004
The observed correlations between pairs of homologous protein sequences are typically explained in terms of a Markovian dynamic of amino acid substitution.
Altschul, Altschul, Bennet, Brenner, Brenner, Bruno, Crooks, Crooks, Felsenstein, Goldman, Goldman, Gonnet, Henikoff, Henikoff, Jones, Koshi, Marti-Renom, Muller, Murzin, M  ller, Park, Schneider, Sjolander, Smith, Thorne, Topham, Yona, Zachariah   +27 more
core   +3 more sources

Non-Canonical Amino Acid-Based Engineering of (R)-Amine Transaminase

Frontiers in Chemistry, 2022
Non-canonical amino acids (ncAAs) have been utilized as an invaluable tool for modulating the active site of the enzymes, probing the complex enzyme mechanisms, improving catalytic activity, and designing new to nature enzymes.
Amol D. Pagar, Hyunwoo Jeon, Taresh P. Khobragade, Sharad Sarak, Pritam Giri, Seonga Lim, Tae Hyeon Yoo, Byoung Joon Ko, Hyungdon Yun   +8 more
doaj   +1 more source

Extending enzyme molecular recognition with an expanded amino acid alphabet

, 2017
Natural enzymes are constructed from the twenty proteogenic amino acids, which may then require post-translational modification or the recruitment of coenzymes or metal ions to achieve catalytic function.
Adam Nelson, Alan Berry, Arwen R. Pearson, Baker, Chalker, Chi H. Trinh, Claire L. Windle, Daniels, Dondoni, Drienovska, Dumas, Díaz-Rodríguez, Hekking, Howard, Huang, James R. Ault, Katie J. Simmons, Montclare, Pradhan, Royer, Timms, Ugwumba, Warren, Williams, Windle, Yukl, Zhang   +26 more
core   +1 more source

Control of DNA minor groove width and Fis protein binding by the purine 2-amino group. [PDF]

, 2013
The width of the DNA minor groove varies with sequence and can be a major determinant of DNA shape recognition by proteins. For example, the minor groove within the center of the Fis-DNA complex narrows to about half the mean minor groove width of ...
Cascio, Duilio, Di Felice, Rosa, Ghane, Tahereh, Hancock, Stephen P, Johnson, Reid C, Rohs, Remo   +5 more
core   +2 more sources

Overview on Multienzymatic Cascades for the Production of Non-canonical α-Amino Acids

Frontiers in Bioengineering and Biotechnology, 2020
The 22 genetically encoded amino acids (AAs) present in proteins (the 20 standard AAs together with selenocysteine and pyrrolysine), are commonly referred as proteinogenic AAs in the literature due to their appearance in ribosome-synthetized polypeptides.
Sergio Martínez-Rodríguez, Jesus M. Torres, Pilar Sánchez, Esperanza Ortega   +3 more
doaj   +1 more source

Basic principles of the genetic code extension [PDF]

Royal Society Open Science, 2020
Compounds including non-canonical amino acids (ncAAs) or other artificially designed molecules can find a lot of applications in medicine, industry and biotechnology.
Paweł Błażej, Małgorzata Wnetrzak, Dorota Mackiewicz, Paweł Mackiewicz   +3 more
doaj   +1 more source

Beyond the Canonical 20: Peptide Discovery with Non-Canonical Amino Acids

CHIMIA
Amino acids are central to biology as signaling molecules and as the building blocks of peptides and proteins, which represent an expanding class of drugs with vast therapeutic potential.
Nathalie M. Grob
doaj   +1 more source

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P., Billker, Oliver, Creek, Darren J., Limenitakis, Julien, Macrae, James I., McConville, Malcolm J., Modrzynska, Katarzyna K., Oppenheim, Rebecca D., Pino, Paco, Polonais, Valerie, Seeber, Frank, Soldati-Favre, Dominique   +11 more
core   +1 more source

Deriving amino acid contact potentials from their frequencies of occurence in proteins: a lattice model study

, 2004
The possibility of deriving the contact potentials between amino acids from their frequencies of occurence in proteins is discussed in evolutionary terms.
Abkkevich V I, Anfinsen C B, Betancourt M R, Bryngelson J D, Creighton T E, D Provasi, Derrida B, Finkelstein A V, G Tiana, Godzik A, Greiner W, Kolinski A, Li H, M Colombo, Miyazawa S, R A Broglia, Rost B, Shakhnovich E I, Shimada J, Sippl M J, Zhang L   +20 more
core   +1 more source

N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana [PDF]

, 2017
Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in ...
Gevaert, Kris, Jonckheere, Veronique, Martens, Lennart, Ndah, Elvis, Stael, Simon, Sticker, Adriaan, Van Breusegem, Frank, Van Damme, Petra, Willems, Patrick   +8 more
core   +1 more source