PLIT: An alignment-free computational tool for identification of long non-coding RNAs in plant transcriptomic datasets [PDF]
, 2019 Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs which play a significant role in several biological processes. RNA-seq based transcriptome sequencing has been extensively used for identification of lncRNAs.
Deshpande, Sumukh +4 more
core +4 more sources
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
Nature Communications, 2016 Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of ...
L. Holdt +17 more
semanticscholar +1 more source
Cells, 2020 miR-28-5p is downregulated in some tumor tissues in which it has been demonstrated to have tumor suppressor (TS) activity. Here, we demonstrate that miR-28-5p acts as a TS in prostate cancer (PCa) cells affecting cell proliferation/survival, as well as ...
Sofia Fazio +7 more
doaj +1 more source
Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]
, 2019 Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh +7 more
core +3 more sources
Acknowledgement to Reviewers of Non-Coding RNA in 2017
Non-Coding RNA, 2018 Peer review is an essential part in the publication process, ensuring that Non-Coding RNA maintains high quality standards for its published papers.[...]
Non-Coding RNA Editorial Office
doaj +1 more source
Expression of long non-coding RNA and mRNA in the hippocampus of mice with type 2 diabetes
Molecular Medicine Reports, 2018 Long non-coding RNAs (lncRNAs) serve key roles in cell growth, development and various diseases associated with the central nervous system. However, differential expression profiles of lncRNAs in type 2 diabetes have not been reported.
L. Ci +7 more
semanticscholar +1 more source
Combined VEGFR and MAPK pathway inhibition in angiosarcoma
Scientific Reports, 2021 Angiosarcoma is an aggressive malignancy of endothelial cells that carries a high mortality rate. Cytotoxic chemotherapy can elicit clinical responses, but the duration of response is limited.
Michael J. Wagner +12 more
doaj +1 more source
Long non-coding RNAs era in liver cancer [PDF]
, 2015 Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population and the sixth most common cancer worldwide.
Guerrieri, Francesca
core +1 more source
The functional role of long non-coding RNA in human carcinomas
Molecular Cancer, 2011 Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however
E. Gibb, Carolyn J. Brown, W. Lam
semanticscholar +1 more source
Identification and characterization of novel conserved RNA structures in Drosophila
BMC Genomics, 2018 Background Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes –
Rebecca Kirsch +5 more
doaj +1 more source