Results 41 to 50 of about 963,524 (371)

Scaling properties of RNA as a randomly branching polymer [PDF]

J. Chem. Phys. 158, 234901 (2023), 2023
Formation of base pairs between the nucleotides of an RNA sequence gives rise to a complex and often highly branched RNA structure. While numerous studies have demonstrated the functional importance of the high degree of RNA branching -- for instance, for its spatial compactness or interaction with other biological macromolecules -- RNA branching ...
arxiv   +1 more source

The functional role of long non-coding RNA in human carcinomas

Molecular Cancer, 2011
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however
E. Gibb, Carolyn J. Brown, W. Lam
semanticscholar   +1 more source

Identification and characterization of novel conserved RNA structures in Drosophila

BMC Genomics, 2018
Background Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes –
Rebecca Kirsch, Stefan E. Seemann, Walter L. Ruzzo, Stephen M. Cohen, Peter F. Stadler, Jan Gorodkin   +5 more
doaj   +1 more source

FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome

Nucleic Acids Research, 2017
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify the different classes of RNAs among the plethora of reconstructed transcripts ...
Valentin Wucher, F. Legeai, B. Hédan, Guillaume Rizk, L. Lagoutte, T. Leeb, V. Jagannathan, É. Cadieu, Audrey David, H. Lohi, S. Cirera, M. Fredholm, Nadine Botherel, P. Leegwater, C. Le Béguec, H. Fieten, Jeremy Johnson, Jessica Alföldi, C. André, K. Lindblad-Toh, C. Hitte, T. Derrien   +21 more
semanticscholar   +1 more source

The role of noncoding RNAs in cancer lipid metabolism

Frontiers in Oncology, 2022
Research on noncoding ribonucleic acids (ncRNAs) is mostly and broadly focused on microRNAs (miRNAs), cyclic RNAs (circRNAs), and long ncRNAs (lncRNAs), which have been confirmed to play important roles in tumor cell proliferation, invasion, and ...
Ye Wang, Ye Wang, Ye Wang, Qian Li, Qian Li, Qian Li, Song Wang, Song Wang, Song Wang, Bi-jun Wang, Yan Jin, Yan Jin, Yan Jin, Hao Hu, Hao Hu, Hao Hu, Qing-sheng Fu, Qing-sheng Fu, Qing-sheng Fu, Jia-wei Wang, Jia-wei Wang, Jia-wei Wang, Qing Wu, Qing Wu, Qing Wu, Long Qian, Long Qian, Long Qian, Ting-ting Cao, Ting-ting Cao, Ting-ting Cao, Ya-bin Xia, Ya-bin Xia, Ya-bin Xia, Xiao-xu Huang, Xiao-xu Huang, Xiao-xu Huang, Li Xu, Li Xu, Li Xu   +39 more
doaj   +1 more source

Non‐Coding RNA Analysis Using the Rfam Database

Current Protocols in Bioinformatics, 2018
Rfam is a database of non‐coding RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. Using a combination of manual and literature‐based curation and a custom software
Ioanna Kalvari, Eric P. Nawrocki, Joanna Argasinska, Natalia Quinones-Olvera, R. Finn, A. Bateman, Anton I. Petrov   +6 more
semanticscholar   +1 more source

Non-Coding RNAs and Endometrial Cancer [PDF]

Genes, 2018
Non-coding RNAs (ncRNAs) are involved in the regulation of cell metabolism and neoplastic transformation. Recent studies have tried to clarify the significance of these information carriers in the genesis and progression of various cancers and their use as biomarkers for the disease; possible targets for the inhibition of growth and invasion by the ...
Vallone C., Rigon G., Gulia C., Baffa A., Votino R., Morosetti G., Zaami S., Briganti V., Catania F., Gaffi M., Nucciotti R., Costantini F. M., Piergentili R., Putignani L., Signore F.   +14 more
openaire   +3 more sources

Associating transcription factors and conserved RNA structures with gene regulation in the human brain

Scientific Reports, 2017
Anatomical subdivisions of the human brain can be associated with different neuronal functions. This functional diversification is reflected by differences in gene expression.
Nikolai Hecker, Stefan E. Seemann, Asli Silahtaroglu, Walter L. Ruzzo, Jan Gorodkin   +4 more
doaj   +1 more source

Predicting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2

Frontiers in Genetics, 2020
Recently, a few animals have been frequently reported to have been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether they are SARS-CoV-2 intermediate hosts is worthy of great attention.
Min Shen, Chao Liu, Run Xu, Zijing Ruan, Shiying Zhao, Huidong Zhang, Wen Wang, Xinhe Huang, Li Yang, Yong Tang, Tai Yang, Xu Jia   +11 more
doaj   +1 more source

Flagella disruption in Bacillus subtilis increases amylase production yield

Microbial Cell Factories, 2022
Background Bacillus subtilis is a Gram-positive bacterium used as a cell factory for protein production. Over the last decades, the continued optimization of production strains has increased yields of enzymes, such as amylases, and made commercial ...
Annaleigh Ohrt Fehler, Thomas Beuchert Kallehauge, Adrian Sven Geissler, Enrique González-Tortuero, Stefan Ernst Seemann, Jan Gorodkin, Jeppe Vinther   +6 more
doaj   +1 more source