Results 41 to 50 of about 895,028 (332)

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. [PDF]

, 2017
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA
Ai, B, Bai, X-F, Cao, H-H, Feng, C-C, He, J-Z, Huang, G-W, Koeffler, HP, Lei, F, Li, C-Q, Li, E-M, Li, M, Li, S, Li, X, Li, X-C, Liao, L-D, Lin, D-C, Liu, Y-J, Shen, J-H, Tang, Z-D, Wang, L-D, Wang, M-R, Wang, Q-Y, Wang, S-H, Wu, B-L, Wu, J-Y, Wu, Z-Y, Xu, L-Y, Xu, Y-J, Xue, Y-J, Zhang, J, Zhao, J-M, Zheng, C-P, Zhu, Y   +32 more
core   +1 more source

Non-Coding RNAs in Glioma [PDF]

Cancers, 2018
Glioma is the most aggressive brain tumor of the central nervous system. The ability of glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, and heterogeneity contribute to an overall survival of approximately 15 months for most patients with high grade glioma.
Ryte Rynkeviciene, Julija Simiene, Egle Strainiene, Vaidotas Stankevicius, Jurgita Usinskiene, Edita Miseikyte Kaubriene, Ingrida Meskinyte, Jonas Cicenas, Kestutis Suziedelis   +8 more
openaire   +3 more sources

CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters

Genome Biology, 2018
Background Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions of off-targets
Ferhat Alkan, Anne Wenzel, Christian Anthon, Jakob Hull Havgaard, Jan Gorodkin   +4 more
doaj   +1 more source

Predicting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2

Frontiers in Genetics, 2020
Recently, a few animals have been frequently reported to have been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether they are SARS-CoV-2 intermediate hosts is worthy of great attention.
Min Shen, Chao Liu, Run Xu, Zijing Ruan, Shiying Zhao, Huidong Zhang, Wen Wang, Xinhe Huang, Li Yang, Yong Tang, Tai Yang, Xu Jia   +11 more
doaj   +1 more source

Flagella disruption in Bacillus subtilis increases amylase production yield

Microbial Cell Factories, 2022
Background Bacillus subtilis is a Gram-positive bacterium used as a cell factory for protein production. Over the last decades, the continued optimization of production strains has increased yields of enzymes, such as amylases, and made commercial ...
Annaleigh Ohrt Fehler, Thomas Beuchert Kallehauge, Adrian Sven Geissler, Enrique González-Tortuero, Stefan Ernst Seemann, Jan Gorodkin, Jeppe Vinther   +6 more
doaj   +1 more source

Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications. [PDF]

, 2016
Non-coding RNAs are crucial regulators for a vast array of cellular processes and have been implicated in human disease. These biological processes represent a hitherto untapped resource in our fight against disease.
Amy Cording (1383558), Beth Thomas (1383564), Eric A. Miska (41828), Mark Carrington (1398), Michael Gormally (1383561), Peter J. Bond (688987), Shankar Balasubramanian (9301)   +6 more
core   +3 more sources

Non-Coding RNAs in Retinoblastoma [PDF]

Frontiers in Genetics, 2019
Retinoblastoma (Rb) is the most common ocular pediatric malignancy that arises from the retina and is caused by a mutation of the two alleles of the tumor suppressor gene, RB1. Although early detection provides the opportunity of controlling the primary tumor with effective therapies, metastatic activity is fatal.
Meropi Plousiou, Ivan Vannini
openaire   +3 more sources

Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2

Journal of Pharmaceutical Analysis, 2021
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global health threat.
Chao Liu, Xiaoxiao Zhu, Yiyao Lu, Xianqin Zhang, Xu Jia, Tai Yang   +5 more
doaj   +1 more source

Non-coding RNAs and retroviruses [PDF]

Retrovirology, 2018
Retroviruses can cause severe diseases such as cancer and acquired immunodeficiency syndrome. A unique feature in the life cycle of retroviruses is that their RNA genome is reverse transcribed into double-stranded DNA, which then integrates into the host genome to exploit the host machinery for their benefits.
Xu Zhang, Xiancai Ma, Shuliang Jing, Hui Zhang, Yijun Zhang   +4 more
openaire   +3 more sources

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome [PDF]

, 2012
Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth and
Brian Merry, João Pedro de Magalhães, Shona H. Wood, Thomas Craig, Yang Li   +4 more
core   +1 more source