Results 51 to 60 of about 1,318,082 (335)

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Molecular Cancer, 2020
Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients.
A. Bhat, S. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, R. Mir, Sachin Kumar, S. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, S. Kuttikrishnan, K. Prabhu, A. Q. Khan, S. Yadav, W. El-Rifai, M. Zargar, H. Zayed, Mohammad Haris, S. Uddin   +20 more
semanticscholar   +1 more source

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome [PDF]

, 2012
Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth and
Brian Merry, João Pedro de Magalhães, Shona H. Wood, Thomas Craig, Yang Li   +4 more
core   +1 more source

Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene

Frontiers in Microbiology, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Lingjie Song, Xianggui Yang, Jinwei Huang, Xiaokui Zhu, Guohui Han, Yan Wan, Ying Xu, Guangxin Luan, Xu Jia   +8 more
doaj   +1 more source

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Nucleic Acids Res., 2018
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety of diseases. A knowledgebase with systematic collection and curation of lncRNA-disease associations is critically important for further examining
Zhenyu Bao, Zhen Yang, Zhou Huang, Yiran Zhou, Qinghua Cui, Dong Dong   +5 more
semanticscholar   +1 more source

The Non-Coding RNA Ontology : a comprehensive resource for the unification of non-coding RNA biology [PDF]

, 2016
In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification.
Alan, Ruttenberg, Blake Judith, A., Dejing, Dou, Jingshan, Huang, Jun, Huan, Karen, Eilbeck, Natale Darren, A., Smith, Barry, Weili, Huang, Zimmermann Michael, T.   +9 more
core  

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

Haematologica, 2018
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions.
Xiao Fang, Feiyang Shen, Christophe Lechauve, Peng Xu, Guowei Zhao, Jacobi Itkow, Fan Wu, Yaying Hou, Xiaohui Wu, Lingling Yu, Huiqing Xiu, Mengli Wang, Ruiling Zhang, Fangfang Wang, Yanqing Zhang, Daxin Wang, Mitchell J. Weiss, Duonan Yu   +17 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

A domain ontology for the non-coding RNA field [PDF]

, 2015
Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to ...
Blake, Judith A., Dou, Dejing, Eilbeck, Karen, Huang, Jingshan, Jiang, Guoqian, Lin, Yu, Natale, Darren A., Ruttenberg, Alan, Smith, Barry, Zimmermann, Michael T.   +9 more
core   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source