Results 61 to 70 of about 1,318,082 (335)

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Neoantigens and NK Cells: “Trick or Treat” the Cancers?

Frontiers in Immunology, 2022
Immunotherapy has become an important treatment strategy for cancer patients nowadays. Targeting cancer neoantigens presented by major histocompatibility complex (MHC) molecules, which emerge as a result of non-synonymous somatic mutations with high ...
Dan Lv, Dan Lv, Dan Lv, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar, Zhengyan Liang, Zhengyan Liang, Yu Gao, Yu Gao, Haibo Sun, Haibo Sun   +11 more
doaj   +1 more source

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. [PDF]

, 2016
Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates ...
Casero, David, Eskin, Ascia, Gilliland, Thomas, Hong, Cynthia, Jones, Marius C, Katz, Melanie, Lee, Richard, Sallam, Tamer, Sandhu, Jaspreet, Tontonoz, Peter, Vallim, Thomas Q de Aguiar, Whitelegge, Julian, Wu, Xiaohui, Zhang, Li   +13 more
core   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The synergistic immunotherapeutic impact of engineered CAR-T cells with PD-1 blockade in lymphomas and solid tumors: a systematic review

Frontiers in Immunology
Currently, therapies such as chimeric antigen receptor-T Cell (CAR-T) and immune checkpoint inhibitors like programmed cell death protein-1 (PD-1) blockers are showing promising results for numerous cancer patients.
Bibhu Prasad Satapathy, Pooja Sheoran, Rohit Yadav, Dewan Chettri, Dhruba Sonowal, Chinmayee Priyadarsini Dash, Prachi Dhaka, Vivek Uttam, Ritu Yadav, Manju Jain, Aklank Jain   +10 more
doaj   +1 more source

Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors. [PDF]

, 2019
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
Bisht, Madhoolika, Campbell, Moray J, Dotts, Kathleen, Elchuri, Sailaja V, Khetan, Vikas, Krishnakumar, Subrmanian, Kumar, Ranjith, Miles, Wayne O, Nagarajha Selvan, Lakshmi Dhevi, Rajasekaran, Swetha, Rishi, Pukhraj, Sahoo, Debashis, Sivaraman, Karthikeyan   +12 more
core   +1 more source

E. coli OxyS non-coding RNA does not trigger RNAi in C. elegans. [PDF]

, 2015
The discovery of RNA interference (RNAi) in C. elegans has had a major impact on scientific research, led to the rapid development of RNAi tools and has inspired RNA-based therapeutics.
Akay, Alper, Miska, Eric A, Sarkies, Peter   +2 more
core   +2 more sources

RNAcentral: a hub of information for non-coding RNA sequences

Nucleic Acids Res., 2018
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences of all types from a broad range of organisms.
B. Sweeney, Anton I. Petrov, Boris Burkov, R. Finn, A. Bateman, M. Szymanski, W. Karłowski, J. Gorodkin, S. Seemann, J. Cannone, Robin Gutell, P. Fey, S. Basu, Simon Kay, G. Cochrane, Kostantinos Billis, D. Emmert, Steven J. Marygold, R. Huntley, R. Lovering, A. Frankish, Patricia P. Chan, T. Lowe, E. Bruford, Ruth L. Seal, J. Vandesompele, P. Volders, M. Paraskevopoulou, Lina Ma, Zhang Zhang, S. Griffiths-Jones, J. Bujnicki, Pietro Boccaletto, J. Blake, C. Bult, Runsheng Chen, Yi Zhao, V. Wood, Kim M Rutherford, Elena Rivas, J. Cole, S. Laulederkind, M. Shimoyama, M. Gillespie, M. Orlic-Milacic, Ioanna Kalvari, Eric P. Nawrocki, S. Engel, J. Cherry, Silva Team, T. Berardini, A. Hatzigeorgiou, Dimitra Karagkouni, K. Howe, Paul Davis, M. Dinger, Shunmin He, M. Yoshihama, N. Kenmochi, P. Stadler, K. Williams   +60 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source