Results 61 to 70 of about 863,687 (283)

Phage Selective Pressure Reduces Virulence of Hypervirulent Klebsiella pneumoniae Through Mutation of the wzc Gene

Frontiers in Microbiology, 2021
Hypervirulent Klebsiella pneumoniae (hvKp), one of the major community-acquired pathogens, can cause invasive infections such as liver abscess. In recent years, bacteriophages have been used in the treatment of K.
Lingjie Song, Xianggui Yang, Jinwei Huang, Xiaokui Zhu, Guohui Han, Yan Wan, Ying Xu, Guangxin Luan, Xu Jia   +8 more
doaj   +1 more source

Non-Coding RNAs and Endometrial Cancer [PDF]

Genes, 2018
Non-coding RNAs (ncRNAs) are involved in the regulation of cell metabolism and neoplastic transformation. Recent studies have tried to clarify the significance of these information carriers in the genesis and progression of various cancers and their use as biomarkers for the disease; possible targets for the inhibition of growth and invasion by the ...
Vallone C., Rigon G., Gulia C., Baffa A., Votino R., Morosetti G., Zaami S., Briganti V., Catania F., Gaffi M., Nucciotti R., Costantini F. M., Piergentili R., Putignani L., Signore F.   +14 more
openaire   +3 more sources

Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

Frontiers in Cell and Developmental Biology, 2022
Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While the tumor can be controlled efficiently at early stages, metastatic tumors lead to high mortality.
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Amirhossein Sheida, Hamed Mirzaei   +13 more
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors. [PDF]

, 2019
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
Bisht, Madhoolika, Campbell, Moray J, Dotts, Kathleen, Elchuri, Sailaja V, Khetan, Vikas, Krishnakumar, Subrmanian, Kumar, Ranjith, Miles, Wayne O, Nagarajha Selvan, Lakshmi Dhevi, Rajasekaran, Swetha, Rishi, Pukhraj, Sahoo, Debashis, Sivaraman, Karthikeyan   +12 more
core   +1 more source

decodeRNA-predicting non-coding RNA functions using guilt-by-association [PDF]

, 2017
Although the long non-coding RNA (lncRNA) landscape is expanding rapidly, only a small number of lncRNAs have been functionally annotated. Here, we present decodeRNA (http://www.decoderna.org), a database providing functional contexts for both human ...
Anckaert, Jasper, Lefever, Steve, Luypaert, Manuel, Mestdagh, Pieter, Vandesompele, Jo, Volders, Pieter-Jan   +5 more
core   +2 more sources

Non-Coding RNAs in Muscle Dystrophies [PDF]

International Journal of Molecular Sciences, 2013
ncRNAs are the most recently identified class of regulatory RNAs with vital functions in gene expression regulation and cell development. Among the variety of roles they play, their involvement in human diseases has opened new avenues of research towards the discovery and development of novel therapeutic approaches.
ERRIQUEZ, DANIELA, PERINI, GIOVANNI, Ferlini A.   +2 more
openaire   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

Haematologica, 2018
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions.
Xiao Fang, Feiyang Shen, Christophe Lechauve, Peng Xu, Guowei Zhao, Jacobi Itkow, Fan Wu, Yaying Hou, Xiaohui Wu, Lingling Yu, Huiqing Xiu, Mengli Wang, Ruiling Zhang, Fangfang Wang, Yanqing Zhang, Daxin Wang, Mitchell J. Weiss, Duonan Yu   +17 more
doaj   +1 more source

Employment opportunities for non‐coding RNAs [PDF]

FEBS Letters, 2004
Analysis of the genomes of several higher eukaryotic organisms, including mouse and human, has reached the striking conclusion that the mammalian transcriptome is constituted in large part of non‐protein‐coding transcripts. Conversely, the number of protein‐coding genes was initially at least overestimated.
Morey, Céline, Avner, Philip
openaire   +2 more sources