Results 61 to 70 of about 963,524 (371)

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Nucleic Acids Res., 2018
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety of diseases. A knowledgebase with systematic collection and curation of lncRNA-disease associations is critically important for further examining
Zhenyu Bao, Zhen Yang, Zhou Huang, Yiran Zhou, Qinghua Cui, Dong Dong   +5 more
semanticscholar   +1 more source

miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

Haematologica, 2018
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions.
Xiao Fang, Feiyang Shen, Christophe Lechauve, Peng Xu, Guowei Zhao, Jacobi Itkow, Fan Wu, Yaying Hou, Xiaohui Wu, Lingling Yu, Huiqing Xiu, Mengli Wang, Ruiling Zhang, Fangfang Wang, Yanqing Zhang, Daxin Wang, Mitchell J. Weiss, Duonan Yu   +17 more
doaj   +1 more source

Neoantigens and NK Cells: “Trick or Treat” the Cancers?

Frontiers in Immunology, 2022
Immunotherapy has become an important treatment strategy for cancer patients nowadays. Targeting cancer neoantigens presented by major histocompatibility complex (MHC) molecules, which emerge as a result of non-synonymous somatic mutations with high ...
Dan Lv, Dan Lv, Dan Lv, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar, Zhengyan Liang, Zhengyan Liang, Yu Gao, Yu Gao, Haibo Sun, Haibo Sun   +11 more
doaj   +1 more source

Non-coding RNA regulatory networks. [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020
It is well established that the vast majority of human RNA transcripts do not encode for proteins and that non-coding RNAs regulate cell physiology and shape cellular functions. A subset of them is involved in gene regulation at different levels, from epigenetic gene silencing to post-transcriptional regulation of mRNA stability.
S. Panni, R. Lovering, P. Porras, S. Orchard   +3 more
semanticscholar   +5 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Comparative Analysis of RNA Families Reveals Distinct Repertoires for Each Domain of Life [PDF]

PLoS Comput Biol. 2012 8(11):e1002752, 2012
The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth. A key part of such models is continuity between the earliest stages in the evolution of life and the RNA repertoires of extant lineages.
arxiv   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma

Frontiers in Immunology, 2023
IntroductionLow-grade glioma (LGG) is a prevalent malignant tumor in the intracranial region. Despite the advancements in treatment methods for this malignancy over the past decade, significant challenges still persist in the form of drug resistance and ...
Bo Shi, Bo Shi, Bo Shi, Fei Ge, Liangliang Cai, Liangliang Cai, Yi Yang, Yi Yang, Xiaohui Guo, Rui Wu, Zhehao Fan, Zhehao Fan, Binjie Cao, Binjie Cao, Ning Wang, Ning Wang, Yue Si, Yue Si, Xinyue Lin, Xinyue Lin, Weibing Dong, Haibo Sun, Haibo Sun   +22 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Long Non-Coding RNA in Cancer [PDF]

International Journal of Molecular Sciences, 2013
Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus ...
Nina Hauptman, Damjan Glavač
openaire   +3 more sources