Results 221 to 230 of about 385,299 (305)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

PymiRa: A rapid and accurate classification tool for small non-coding RNAs, including microRNAs. [PDF]

PLoS Comput Biol
Scurlock ZGL, Scarpini CG, Coleman N, Murray MJ, Enright AJ.   +4 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Circulating non-canonical small non-coding RNAs as novel diagnostic biomarkers for tuberculosis. [PDF]

Microbiol Spectr
Yang P, Zhan S, Zhu Y, Yu Z, Zhang X, Dong N, Xie S, Miao R, Shen H, Wang X, Zhang C, Yan H.   +11 more
europepmc   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Long non-coding RNAs in response to Ebola virus vaccine-induced immunity. [PDF]

Front Immunol
Mamede I, Luschër-Dias T, Moscardini IF, Gonzales-Dias P, Marinho B, Marcon F, Dominguez Crespo Hirata T, Eichberg M, Medaglini D, Harandi AM, Siegrist CA, Ottenhoff THM, Santoro F, Gonçalves A, Ferreira DM, Polidoro R, Franco GR, Amaral PP, Nakaya H, Addo MM, VSV-EBOPLUS Consortium .   +20 more
europepmc   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

Correction: Long non-coding RNAs in response to Ebola virus vaccine-induced immunity. [PDF]

Front Immunol
Mamede I, Luschër-Dias T, Moscardini IF, Gonzales-Dias P, Marinho B, Marcon F, Hirata TDC, Eichberg M, Medaglini D, Harandi AM, Siegrist CA, Ottenhoff THM, Santoro F, Addo MM, Gonçalves A, Ferreira DM, Polidoro R, Franco GR, Amaral PP, Nakaya H, VSV-EBOPLUS Consortium .   +20 more
europepmc   +1 more source