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Dysregulation of circular RNAs in inflammation and cancers
Fundamental Research, 2023 Emerging lines of evidence have shown that the production of the covalently closed single-stranded circular RNAs is not splicing errors, but rather a regulated process with distinct biogenesis and turnover. Circular RNAs are expressed in a cell type- and
Jiayu Liu +3 more
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EXCLI Journal : Experimental and Clinical Sciences, 2023 Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes
Mina Alimohammadi +7 more
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The role of circular RNAs in brain and stroke
Frontiers in Bioscience-Landmark, 2021 Circular RNAs are single-stranded RNAs which are closed by covalent bonds during splicing. Different from other RNAs, circular RNAs are well known due to their circular structure. In recent years, many researches were conducted to investigate the role of
Yu-Ye Wang +3 more
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Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer
Frontiers in Cell and Developmental Biology, 2022 Circular RNAs are single-stranded RNAs with a covalently closed structure formed by the process of back-splicing. Aberrant expression of circular RNAs contributes to the pathogenesis of a wide range of cancers. Pancreatic cancer is one of the most lethal
Takahiro Seimiya +2 more
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Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs
Frontiers in Microbiology, 2021 Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa +10 more
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Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System
Life, 2020 The identified non-coding RNAs (ncRNAs) include circular RNAs, long non-coding RNAs, microRNAs, ribosomal RNAs, small interfering RNAs, small nuclear RNAs, piwi-interacting RNAs, and transfer RNAs, etc.
Xiaolan Chen +3 more
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Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer
Cancer Medicine, 2021 Background Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. According to the research of circular RNAs in the CRC field, compared with linear RNAs, circular RNAs are a special type of noncoding RNA that are ...
Shunhao Zhang +4 more
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Veterinary Sciences, 2023 Circular RNAs are widespread in various species and have important roles in myogenesis. However, the circular RNAs involved in breast muscle development in ducks have not yet been studied.
Jing Liu +6 more
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Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma
Frontiers in Genetics, 2021 Exonic circular RNAs (circRNAs) are a novel subgroup of non-coding RNAs, which are generated by a back-splicing mechanism of the exons or introns. Unlike the linear RNA, circRNA forms a covalently closed loop, and it normally appears more abundant than ...
Menglan Wang +4 more
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Circular RNA: new star, new hope in cancer
BMC Cancer, 2018 Background Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. The diverse types of circular RNAs with varying cytogenetics in cancer have also been reported.
Zikang Zhang +6 more
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