Results 11 to 20 of about 2,013,218 (333)
Optimal design of synthetic circular RNAs
Experimental and Molecular MedicineCircular RNAs are an unusual class of single-stranded RNAs whose ends are covalently linked via back-splicing. Due to their versatility, the need to express circular RNAs in vivo and in vitro has increased.
Seo-Won Choi, Jin-Wu Nam
doaj +3 more sources
Detecting and characterizing circular RNAs
Nature Biotechnology, 2014 Circular RNA transcripts were first identified in the early 1990s but knowledge of these species has remained limited, as their study has been difficult through traditional methods of RNA analysis.
William R Jeck +2 more
exaly +4 more sources
Circular RNAs in Heart Failure [PDF]
European Journal of Heart Failure, 2017 Cardiovascular disease, and particularly heart failure, is still a serious health care issue for which novel treatments and biomarkers are needed. The RNA family comprises different subgroups, among which the small-sized microRNAs and the larger long non-
Yvan Devaux +2 more
exaly +4 more sources
Molecular Therapy: Nucleic Acids, 2019 Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops.
Duc-Hiep Bach +2 more
doaj +5 more sources
Circular RNAs: Characterization, cellular roles, and applications
Cell, 2022 Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs. Recent technological advances have in part overcome problems with their circular conformation and sequence overlap with linear cognate mRNAs, allowing a better ...
Chu-Xiao Liu, Ling-Ling Chen
exaly +2 more sources
Circular RNAs: Non-Canonical Observations on Non-Canonical RNAs
Cells, 2023 The existence of circular RNA (circRNA) research in mainstream science can be attributed to the contemporary synergism of big data and keen attention to detail by several research groups worldwide.
Brett W. Stringer +2 more
doaj +2 more sources
Circular RNAs as Promising Biomarkers: A mini-review
Frontiers in Physiology, 2016 The interest in circular RNAs has resurfaced in the past few years. What was considered as junk for nearly two decades is now one of the most interesting molecules.
Nadiah Abu, Rahman Jamal
doaj +2 more sources
Dysregulation of circular RNAs in inflammation and cancers
Fundamental Research, 2023 Emerging lines of evidence have shown that the production of the covalently closed single-stranded circular RNAs is not splicing errors, but rather a regulated process with distinct biogenesis and turnover. Circular RNAs are expressed in a cell type- and
Jiayu Liu +3 more
doaj +2 more sources
Circular RNAs are abundant, conserved, and associated with ALU repeats
RNA: A publication of the RNA Society, 2013 Circular RNAs composed of exonic sequence have been described in a small number of genes. Thought to result from splicing errors, circular RNA species possess no known function.
Sharpless, N. E. +7 more
core +2 more sources
, 2021 Although the type and amount of salivary components are influenced by many factors, due to easy, quick, cheap, and noninvasive sampling method alongside with the existence of the vast majority of the substances found in peripheral blood and urine in it ...
Ghods, Farinaz Jafari
core +3 more sources