Results 31 to 40 of about 761,097 (299)

Diagnostic Accuracy of Circular RNAs in Different Types of Samples for Detecting Hepatocellular Carcinoma: A Meta-Analysis

Frontiers in Genetics, 2021
The lack of accurate biomarkers impeded the screening, diagnosis and early treatment of hepatocellular carcinoma (HCC). As a result of the development of high-throughput transcriptome analysis techniques, circular RNAs, a newly discovered class of ...
Guilin Nie, Dingzhong Peng, Bei Li, Jiong Lu, Xianze Xiong   +4 more
doaj   +1 more source

Interior circular RNA [PDF]

RNA Biology, 2019
Formed by back splicing or back fusion of linear RNAs, circular RNAs (circRNAs) constitute a new class of non-coding RNAs of eukaryotes. Recent studies reveal a spliceosome-dependent biogenesis of circRNAs where circRNAs arise at the intron-exon junctions of mRNAs.
Xiaoxin Liu, Zhangfeng Hu, Junfei Zhou, Cheng Tian, Guangmei Tian, Miao He, Lifen Gao, Lihong Chen, Tiantian Li, Hai Peng, Weixiong Zhang   +10 more
openaire   +2 more sources

Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]

, 2013
: OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes.
Taylor, James E., Callaghan, Anastasia J., Helen A. Vincent, Phillips, Jack O., Cary, Peter, Vincent, H., Peter D. Cary, Sobott, F., Jack O. Phillips, Frank Sobott, Vincent, Helen A., Henderson, Charlotte A., Stone, Carlanne, Alessandra Casamento, Henderson, Charlotte, Carlanne M. Stone, Anastasia J. Callaghan, Darren M. Gowers, Cary, Peter D., Charlotte A. Henderson, James E.N. Taylor, Casamento, A., Callaghan, Anastasia, Phillips, Jack, Gowers, Darren, Casamento, Alessandra, Stone, Carlanne M., Sobott, Frank, Gowers, Darren M.   +28 more
core   +1 more source

Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells

iScience, 2018
Summary: Circular RNAs constitute a unique class of RNAs whose precise functions remain to be elucidated. In particular, cancer-associated chromosomal translocations can give rise to fusion circular RNAs that play a role in leukemia progression. However,
Loelia Babin, Marion Piganeau, Benjamin Renouf, Khadija Lamribet, Cecile Thirant, Ludovic Deriano, Thomas Mercher, Carine Giovannangeli, Erika C. Brunet   +8 more
doaj   +1 more source

Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs

Molecules and Cells, 2023
RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks
Mingyu Ju, Dayeon Kim, Geurim Son, Jinju Han   +3 more
openaire   +2 more sources

Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p

Technology in Cancer Research & Treatment, 2020
This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer.
Ziqi Peng BM, Boyang Xu BM, Feng Jin MD
doaj   +1 more source

Circ2Traits: A comprehensive database for circular RNA potentially associated with disease and traits

Frontiers in Genetics, 2013
Circular RNAs are new players in regulation of post transcriptional gene expression. Animal genomes express many circular RNAs from diverse genomic locations.
Suman eGhosal, Shaoli eDas, Rituparno eSen, Piyali eBasak, Jayprokas eChakrabarti   +4 more
doaj   +1 more source

A guide to naming eukaryotic circular RNAs [PDF]

, 2023
Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs - including linear RNAs and circular RNAs (circRNAs) - from a single gene locus.
Nikolaus Rajewsky, Kjems, J., Wilusz, Jeremy E, Thomas B. Hansen, Yang, Li, Bozzoni, I., Matera, A.G., Jeremy E. Wilusz, Rajewsky, N., Wilusz, J.E., Yang, L., Jørgen Kjems, Chen, Ling-Ling, Salzman, Julia, Matera, A Gregory, Ling-Ling Chen, Bindereif, Albrecht, Ma, Xu-Kai, Xu-Kai Ma, Hansen, Thomas B, Albrecht Bindereif, Kjems, Jørgen, Salzman, J., Julia Salzman, Rajewsky, Nikolaus, Chen, L.L., Bozzoni, Irene, Gorospe, Myriam, Gorospe, M., Bindereif, A., Pek, J.W., Zhao, Fangqing, Hansen, T.B., Irene Bozzoni, A. Gregory Matera, Zhao, F., Chang, Howard Y, Fangqing Zhao, Ma, X.K., Howard Y. Chang, Li Yang, Myriam Gorospe, Jun Wei Pek, Chang, H.Y., Pek, Jun Wei   +44 more
core   +1 more source

Silencing of circRNA.2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy

Molecular Therapy: Nucleic Acids, 2018
Circular RNAs (circRNAs) represent a class of non-coding RNAs that are involved in transcriptional and posttranscriptional gene expression regulation and associated with different kinds of human diseases.
Zhi-bin Zhou, Yu-long Niu, Gao-xiang Huang, Jia-jia Lu, Aimin Chen, Lei Zhu   +5 more
doaj   +1 more source

Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder

Translational Psychiatry, 2021
Gene expression dysregulation in the brain has been associated with bipolar disorder, but little is known about the role of non-coding RNAs. Circular RNAs are a novel class of long noncoding RNAs that have recently been shown to be important in brain ...
Rixing Lin, Juan Pablo Lopez, Cristiana Cruceanu, Caroline Pierotti, Laura M. Fiori, Alessio Squassina, Caterina Chillotti, Christoph Dieterich, Nikolaos Mellios, Gustavo Turecki   +9 more
doaj   +1 more source