Results 21 to 30 of about 2,013,218 (333)

Circular RNAs and their roles in head and neck cancers

Molecular Cancer, 2019
Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′ polyadenylation tail that modify liner mRNAs and have no terminal structures.
Yang Guo, Jiechao Yang, Qiang Huang, Chiyao Hsueh, Juan Zheng, Chunping Wu, Hui Chen, Liang Zhou   +7 more
doaj   +2 more sources

Circular RNAs

EXCLI Journal : Experimental and Clinical Sciences, 2023
Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes
Mina Alimohammadi, Yasaman Gholinezhad, Vahide Mousavi, Samaneh Kahkesh, Malihe Rezaee, Alireza Yaghoobi, Alireza Mafi, Mahmood Araghi   +7 more
doaj   +2 more sources

A guide to naming eukaryotic circular RNAs [PDF]

Nature Cell Biology, 2023
Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs - including linear RNAs and circular RNAs (circRNAs) - from a single gene locus.
Nikolaus Rajewsky, Kjems, J., Wilusz, Jeremy E, Thomas B. Hansen, Yang, Li, Bozzoni, I., Matera, A.G., Jeremy E. Wilusz, Rajewsky, N., Wilusz, J.E., Yang, L., Jørgen Kjems, Chen, Ling-Ling, Salzman, Julia, Matera, A Gregory, Ling-Ling Chen, Bindereif, Albrecht, Ma, Xu-Kai, Xu-Kai Ma, Hansen, Thomas B, Albrecht Bindereif, Kjems, Jørgen, Salzman, J., Julia Salzman, Rajewsky, Nikolaus, Chen, L.L., Bozzoni, Irene, Gorospe, Myriam, Gorospe, M., Bindereif, A., Pek, J.W., Zhao, Fangqing, Hansen, T.B., Irene Bozzoni, A. Gregory Matera, Zhao, F., Chang, Howard Y, Fangqing Zhao, Ma, X.K., Howard Y. Chang, Li Yang, Myriam Gorospe, Jun Wei Pek, Chang, H.Y., Pek, Jun Wei   +44 more
core   +2 more sources

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

Cell, 2019
Circular RNAs (circRNAs) produced from back-splicing of exons of pre-mRNAs are widely expressed, but current understanding of their functions is limited.
Chu-Xiao Liu, Fang Nan, Huihua Ding
exaly   +2 more sources

Biogenesis of Circular RNAs [PDF]

Cell, 2014
Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al.
Vicens, Quentin, Westhof, Eric
core   +3 more sources

Translation of circular RNAs

Nucleic Acids Research
Circular RNAs (circRNAs) are covalently closed RNAs that are present in all eukaryotes tested. Recent RNA sequencing (RNA-seq) analyses indicate that although generally less abundant than messenger RNAs (mRNAs), over 1.8 million circRNA isoforms exist in
G. Margvelani, Karol Andrea Arizaca Maquera, Justin R Welden, David W. Rodgers, Stefan Stamm   +4 more
semanticscholar   +3 more sources

Biogenesis and Regulatory Roles of Circular RNAs

Annual Review of Cell and Developmental Biology, 2022
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular housekeeping noncoding RNAs and precursor messenger RNAs.
Wilusz, Jeremy E, Yang, Li, Chen, Ling-Ling   +2 more
core   +2 more sources

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia [PDF]

Cells, 2020
Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation.
Artem Nedoluzhko, Natalia Gruzdeva, Fedor Sharko, Sergey Rastorguev, Natalia Zakharova, Georgy Kostyuk, Vadim Ushakov   +6 more
doaj   +2 more sources

The biogenesis, biological functions and modification of Circular RNAs

Experimental and Molecular Pathology, 2023
Circular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm.
Sen Liu, Xiangyu Guo, Qing Shang, Peng Gao   +3 more
exaly   +2 more sources

Circular RNAs in Cancer

, 2018
Circular RNAs (circRNAs) constitute a class of RNAs that only recently have come into the focus of the scientific cancer community after it was revealed that they are very abundant, highly conserved across species and show tissue- and developmental stage-
Bullinger, L., Lars Bullinger, Susanne Lux, Lux, S.   +3 more
core   +3 more sources