Results 51 to 60 of about 2,013,218 (333)
CircRNA: functions and properties of a novel potential biomarker for cancer
Molecular Cancer, 2017 Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail.
Shujuan Meng +6 more
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Frontiers in Genetics, 2021 The lack of accurate biomarkers impeded the screening, diagnosis and early treatment of hepatocellular carcinoma (HCC). As a result of the development of high-throughput transcriptome analysis techniques, circular RNAs, a newly discovered class of ...
Guilin Nie +4 more
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Extensive translation of circular RNAs driven by N6-methyladenosine
Cell Research, 2017 Extensive pre-mRNA back-splicing generates numerous circular RNAs (circRNAs) in human transcriptome. However, the biological functions of these circRNAs remain largely unclear.
Yun Yang +12 more
semanticscholar +1 more source
Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs
Molecules and Cells, 2023 RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks
Mingyu Ju +3 more
openaire +2 more sources
iScience, 2018 Summary: Circular RNAs constitute a unique class of RNAs whose precise functions remain to be elucidated. In particular, cancer-associated chromosomal translocations can give rise to fusion circular RNAs that play a role in leukemia progression. However,
Loelia Babin +8 more
doaj +1 more source
The Biogenesis, Functions, and Challenges of Circular RNAs.
Molecules and Cells, 2018 Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low levels and often exhibit cell-type-specific and tissue-specific patterns. Recent
Xiang Li, Li Yang, Ling-Ling Chen
semanticscholar +1 more source
RNA Biology, 2019 Formed by back splicing or back fusion of linear RNAs, circular RNAs (circRNAs) constitute a new class of non-coding RNAs of eukaryotes. Recent studies reveal a spliceosome-dependent biogenesis of circRNAs where circRNAs arise at the intron-exon junctions of mRNAs.
Xiaoxin Liu +10 more
openaire +2 more sources
Frontiers in Genetics, 2013 Circular RNAs are new players in regulation of post transcriptional gene expression. Animal genomes express many circular RNAs from diverse genomic locations.
Suman eGhosal +4 more
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Technology in Cancer Research & Treatment, 2020 This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer.
Ziqi Peng BM, Boyang Xu BM, Feng Jin MD
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Expanded identification and characterization of mammalian circular RNAs
Genome Biology, 2014 BackgroundThe recent reports of two circular RNAs (circRNAs) with strong potential to act as microRNA (miRNA) sponges suggest that circRNAs might play important roles in regulating gene expression.
Junjie U. Guo +3 more
semanticscholar +1 more source