Results 71 to 80 of about 2,013,218 (333)
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
Nature Neuroscience, 2015 Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Using deep RNA profiling in different mouse tissues, we observed that circRNAs were substantially enriched in brain and a disproportionate fraction of them were derived from host ...
X. You +17 more
semanticscholar +1 more source
, 2018 Recent advances in RNA sequencing and bioinformatic analysis have allowed the development of a new research field: circular RNAs (circRNAs). These members of the non-coding transcriptome are generated by backsplicing, which results in a covalently closed, single-stranded RNA molecule.
Vea, A +2 more
openaire +3 more sources
PLoS Biology, 2020 In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats and retrotransposons; however, the roles of these sequences in the structure and function of the centromere are unclear.
Yalin Liu +5 more
doaj +1 more source
Next generation sequencing for studying viruses and RNA silencing-based antiviral defense in crop plants [PDF]
, 2014 The main objectives of this work have been to use next generation sequencing (NGS) and develop bioinformatics tools for plant virus diagnostics and genome reconstruction as well as for investigation of RNA silencing-based antiviral defense.
Seguin, Jonathan
core +1 more source
Circular RNAs in breast cancer diagnosis, treatment and prognosis
Oncology Research, 2023 Breast cancer has surpassed lung cancer to become the most common malignancy worldwide. The incidence rate and mortality rate of breast cancer continue to rise, which leads to a great burden on public health.
Xiaojia Huang +4 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses
Molecular Therapy: Nucleic Acids, 2022 Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by in vitro transcription and ligation. Formerly,
Janina Breuer +6 more
doaj +1 more source
Comprehensive Analysis of Circular RNAs in Endothelial Cells
, 2023 Non-coding RNAs constitute a heterogeneous group of molecules that lack the ability to encode proteins but retain the potential ability to influence cellular processes through a regulatory mechanism.
Studzińska, Dorota +9 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The enigma of circular RNA [PDF]
Nature Reviews Immunology, 2019 This study shows that circular RNAs that contain double-stranded regions can modulate innate immunity by inhibiting the pattern recognition receptor protein kinase R (PKR).
openaire +2 more sources