Results 71 to 80 of about 102,540 (304)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Characterization of circular RNAs in dorsal root ganglia after central and peripheral axon injuries

Frontiers in Cellular Neuroscience, 2022
In central nervous system, axons fail to regenerate after injury while in peripheral nervous system, axons retain certain regenerative ability. Dorsal root ganglion (DRG) neuron has an ascending central axon branch and a descending peripheral axon branch
Hong-Jun Cao, Li Huang, Meng-Ru Zheng, Tao Zhang, Ling-Chi Xu   +4 more
doaj   +1 more source

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons [PDF]

, 2017
The RNA-binding protein FUS participates in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
Bozzoni, Irene, Caffarelli, Elisa, Capauto, Davide, Colantoni, Alessio, DE SANTIS, Riccardo, DINI MODIGLIANI, Stefano, Errichelli, Lorenzo, Laneve, Pietro, Legnini, Ivano, Lu, Lei, Morlando, Mariangela, Peruzzi, Giovanna, Rosa, Alessandro, Scarfò, Rebecca, Shneider, Neil A.   +14 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

Circular RNAs as Urinary Biomarkers [PDF]

Clinical Chemistry, 2019
Circular RNAs (circRNAs)3 bear a unique topological feature of circularity among the RNA species. CircRNAs, together with other RNA species without protein-coding potential, are grouped as noncoding RNAs (1). They are single-stranded, covalently closed circular RNA molecules and are hypothesized to be mainly generated through back-splicing of exons ...
W K, Jacky Lam, Y M, Dennis Lo
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA in Diseased Heart

Cells, 2020
Heart disease remains the leading cause of death globally and leads to tremendous socio-economic burden. Despite advances in the field of cardiovascular research, novel theranostics are still in urgent need.
Ying Wang, Bin Liu
doaj   +1 more source

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. [PDF]

, 2019
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC).
Bateman, Randall J, Budde, John P, Chhatwal, Jasmeer P, Cruchaga, Carlos, Del-Aguila, Jorge L, Dominantly Inherited Alzheimer Network (DIAN), Dube, Umber, Farias, Fabiana, Fernandez, Maria Victoria, Gentsch, Jen, Graff-Radford, Neill R, Harari, Oscar, Hsu, Simon, Ibanez, Laura, Jiang, Shan, Karch, Celeste M, Lee, Jae-Hong, Li, Zeran, Masters, Colin L, Morris, John C, Norton, Joanne, Salloway, Stephen, Wang, Fengxian   +22 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source