Results 81 to 90 of about 2,013,218 (333)

Engineering circular RNA regulators to specifically promote circular RNA production

Theranostics, 2021
Background: A large number of circular RNAs (circRNAs) have been discovered in the mammalian transcriptome with high abundance, which play vital roles in gene regulation, thereby participating in the development of multiple diseases. However, the biogenesis, regulation, and especially manipulation of circRNAs still remain largely unknown.
Qi, Yangfan, Han, Wei, Chen, Dan, Zhao, Jinyao, Bai, Lu, Huang, Fang, Dai, Zhenwei, Li, Gang, Chen, Chaoqun, Zhang, Wenjing, Zhang, Jinrui, Jin, Bilian, Wang, Yang   +12 more
openaire   +2 more sources

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

Molecular Metabolism, 2018
Objective: There is strong evidence for an involvement of different classes of non-coding RNAs, including microRNAs and long non-coding RNAs, in the regulation of β-cell activities and in diabetes development.
Lisa Stoll, Jonathan Sobel, Adriana Rodriguez-Trejo, Claudiane Guay, Kailun Lee, Morten Trillingsgaard Venø, Jørgen Kjems, D. Ross Laybutt, Romano Regazzi   +8 more
doaj   +1 more source

Circular RNAs function as ceRNAs to regulate and control human cancer progression

Molecular Cancer, 2018
Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron cyclization, forming a complete ring structure. circRNA is more stable and conservative than linear RNA and abounds in various organisms.
Yaxian Zhong, Yajun Du, Xue Yang, Yongzhen Mo, Chunmei Fan, F. Xiong, Daixi Ren, Xin Ye, Chunwei Li, Yumin Wang, F. Wei, Can Guo, Xu Wu, Xiaoling Li, Yong Li, Gui-yuan Li, Zhaoyang Zeng, W. Xiong   +17 more
semanticscholar   +1 more source

Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy

International Journal of Molecular Sciences, 2023
Hepatocellular carcinoma (HCC) is a highly fatal malignancy with limited therapeutic options and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint inhibitors (ICIs) have emerged as a new paradigm shift in oncology. ICIs,
Tasneem Abaza, M. A. El-Aziz, Kerolos Ashraf Daniel, P. Karousi, Maria Papatsirou, S. Fahmy, N. Hamdy, C. Kontos, R. Youness   +8 more
semanticscholar   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The function and mechanisms of action of circular RNAs in Urologic Cancer

Molecular Cancer, 2023
Kidney, bladder, and prostate cancer are the three major tumor types of the urologic system that seriously threaten human health. Circular RNAs (CircRNAs), special non-coding RNAs with a stabile structure and a unique back-splicing loop-forming ability ...
Zi-Hao Zhang, Yue Wang, Ya Zhang, Sheng-Feng Zheng, Tao Feng, X. Tian, Mierxiati Abudurexiti, Zhenda Wang, Wenkai Zhu, Jia-Qi Su, Hai-Liang Zhang, G. Shi, Ziliang Wang, D. Cao, D. Ye   +14 more
semanticscholar   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Circular RNAs: New players in thyroid cancer

, 2020
The prevalence of thyroid cancer the most frequent endocrine malignancy, is rapidly increasing. Most of thyroid cancers are relatively indolent, however, some cases still possess a risk of developing into lethal types of thyroid cancer.
Derakhshan, M., Borran, S., Azarash, Z., Rezaei, S., Ahmadi, G., Modabberi, M., Akhbari, M., Anari, M.M., Razaviyan, J., Mirzaei, H.   +9 more
core   +2 more sources

Knockout of circRNAs by base editing back-splice sites of circularized exons

Genome Biology, 2022
Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs. Methods for circRNA-specific knockout are lacking, largely due to sequence overlaps between forms. Here, we
Xiang Gao, Xu-Kai Ma, Xiang Li, Guo-Wei Li, Chu-Xiao Liu, Jun Zhang, Ying Wang, Jia Wei, Jia Chen, Ling-Ling Chen, Li Yang   +10 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source