Results 101 to 110 of about 761,097 (299)

Circular RNAs in Tumor Therapy [PDF]

Contrary to the common belief that circRNAs are "mistakes" in RNA splicing, mammalian cells really contain a large number of highly conserved circRNAs. CircRNAs may produce miRNA inhibitors that are stable and potent.
Nader, Baker G., Ibrahim, Noor Alhuda Kh, Mohammad, Wasnaa J.   +2 more
core   +2 more sources

Ferroptosis and circular RNAs

EXCLI Journal : Experimental and Clinical Sciences
Cancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy.
Asif Ahmad Bhat, Neelima Kukreti, Muhammad Afzal, Ahsas Goyal, Riya Thapa, Haider Ali, Moyad Shahwan, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta   +12 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Circular on Economic Utilization and Efficient Delivery of Telephone Services in the Public Service

, 2010
Your attention is drawn to Circular No. OP/CAB/15/SA (2) of 26th August 2003 which provided guidelines on the above subject. The current circular provides for officers in Job Group "N" and above, and leaves out some officers performing key functions in ...
Executive Office of the President
core  

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

Cell Reports, 2014
Summary: Circularization was recently recognized to broadly expand transcriptome complexity. Here, we exploit massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >100 libraries covering diverse developmental stages, tissues ...
Jakub O. Westholm, Pedro Miura, Sara Olson, Sol Shenker, Brian Joseph, Piero Sanfilippo, Susan E. Celniker, Brenton R. Graveley, Eric C. Lai   +8 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Functional analysis of circular RNAs

, 2018
Circular RNAs characterize a class of widespread and diverse endogenous RNAs which are non-coding RNAs that are made by back-splicing events and have covalently closed loops with no polyadenylated tails.
Yeng Chen (94981), Mei Li Ng (9875449), Soundararajan Vijayarathna (13587772), Chern Ein Oon (7441589), Jagat R Kanwar (13358832), Sreenivasan Sasidharan (13587775), Hisham Alkatib Huda (13587769), Shanmugapriya (13498087)   +7 more
core  

Juntos : campaña Ciudades del Caribe Circular

, 2023
¿Cómo enfrentamos la problemática de contaminación por plásticos? Lo hacemos juntos, todos los sectores: gobiernos centrales, gobiernos locales, iniciativa privada y sociedad civil.
Proyecto Caribe Circular
core  

Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Journal of Ovarian Research, 2019
Circular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse RNA molecules with a range of activities such as translation and splicing ...
Zahra Shabaninejad, Asma Vafadar, Ahmad Movahedpour, Younes Ghasemi, Afshin Namdar, Hadis Fathizadeh, Mohammad Hossein Pourhanifeh, Amir Savardashtaki, Hamed Mirzaei   +8 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source